1. Autoimmune Disease Rheumatoid Arthritis And Systemic Lupus Erythematosus 1

2. What is autoimmune disease? Characteristics – Inappropriate response of immune system – Against self components – Tissue destruction – Sometimes fatal RA and SLE – Autoantibody – Immune complex 2

3. Rheumatoid Arthritis Mechanism – Rheumatoid factors – Binding with IgG (Fc part) – IgM-IgG complexes deposited in the joints – Type III hypersensitive 圖、 IgG 結構 圖、 Type III hypersensitive 3

4. Typelll Hypersensitivity 4

5. Rheumatoid Arthritis Symptoms – Joints become red, swollen, painful, and tender production of excessive joint fluid – Joints are usually inflamed in a symmetrical pattern – Loss of cartilage – Erosion and weakness of the bones 5

6. Mechanism - Type IIIhypersensitive SLE 6

7. Symptoms - Harms the heart, joints, skin, lungs, blood vessel, liver, kidneys, and nervous system. -Is dubbed ” the great imitators”. -female:male=10:1 SLE 7

8. 參考資料 Thomas J. Kindt; Richard A. Goldsby. Immunology. Freeman. http://www.medicinenet.com/rheumatoid_arthritis/page2.htm http://en.wikipedia.org/wiki/Type_III_hypersensitivity http://en.wikipedia.org/wiki/Immunoglobulin_G 8