1. Structure and Function of Chemokines/Receptors
Structure and Function of Chemokines/Receptors with Overall Goal to Contribute to Drug Development
Multiple Sclerosis
Rheumatoid Arthritis
Neuroinflammation
Pain
Transplant Rejection
Asthma
Allergy
Atherosclerosis
Cancer Metastasis
Diabetes
HIV

2. Core Expertise: Biochemistry, Structural Biology, Cell Biology, Membrane Proteins
Example: CXCR4:vMIP-II
Qin et al, Accepted to Science. 2015

3. Core Expertise: Biochemistry, Structural Biology, Biophysics, Cell Biology, Membrane Proteins
Cell-Based Assays; e.g. Ligand induced
Receptor Internalization
CCR2 with Small Molecule Cmpds
Low off-rate and allosteric cmpds
+ allosteric cmpd
decreasing off rate
SPR for Interaction Affinities

4. Proposed Collaborations with SSPPS Faculty
Ruben Abagyan: Docking and Structure analysis of chemokine receptors
Dio Siegel: Small molecule compounds for chemokine receptor structures
Bill Gewick: Natural products targeting chemokine receptors
Jim McKerrow and Larissa Podust: membrane protein targets in tropical diseases
Victor Nizet: Chemokines/receptors in microbial pathogenesis
Debbie Spector: Chemokine/receptors and CMV
Pieter Dorrestein: Chemokines/receptor in cell-cell communication by MS
Geoffrey Chang: Nanobodies/antibodies against chemokine receptors
Dong Wang: Stabilization of protein-protein complexes by disulfide locks for structure determination