1. Epidemiological study on INVASIVE BREAST CANCER treated at Hotel Dieu de France Hospital University of Saint-Joseph Faculty of Medicine Gerard Abadjian, M.D. Assistant Professor of Pathology Head of department of Pathology Hotel Dieu de France Hospital Maguy Abou Hamad, M.D. Department of Pathology Hotel Dieu de France Hospital Clement El Khoury, M.D. First year Medicine Residency Hotel Dieu de France Hospital Retrospective study on 434 cases (1999-2006)

2. Plan of the Study ● Descriptive: Age, tumor size, type & histological grade, number of positive lymph nodes. ● Analytical: Modification of these variables threw time. Relations between variables. ● Comparative: Cases between July 1991 & June 1999.

3. Material & Methodes Data collection -> Pathology registers Exclusion criterias: -> Male patients -> Neoadjuvant therapy -> Biopsy before surjery. Histological grading -> Scarff-Bloom- Richardson (SBR) Statistical analysis -> SPSS 11.0®

4. Results Average age -> 53.6 yrs, no variation linked to time Tumor size -> constant 3.2 cm Infiltrating ductal carcinoma the most frequent, Grade III (SBR) Number of postive lymph nodes + histological grading increase along with tumor size.

5. Age Average age -> 53.6 yrs Most frequent age section -> 40-49 yrs Age -/-> Time

6. Tumor size variation between 1991 & 2006 2000 Study Current study

7. Tumor size ≤ 1 cm

8. Carcinoma in situ

9. Variation of positive lymph nodes from 1991 till 2006 Number of positive lymph nodes 2000 studyCurrent study

11. Conclusion Stability of tumor size over the years including ≤ 1 cm => uneffective screening strategies + poor educational programs. Solutions: -> Well organized national screening programs. -> Extensive clinical & pathological studies. -> Educational & advertising campaigns. -> Initiation of all women for breast self- examination test.

13. Thank you