1. Activities/assessments Intermediate outcomesBroad outcomes Human-microbe interactions Living systems are interconnected and interacting. While microbes can harm us, we require interactions with them to survive. Microbes interact with humans in various ways, beneficial, neutral, and detrimental. Hypothesize the response of the body to a microbe. Describe several ways that the human microbiome influences the host. Design an experimental scheme to study microbes in ‘natural communities’ Jigsaw: several articles, mix of beneficial microbes and pathogenic microbes. In groups, draw the interactions between the organism and host. Mix up groups with one person from each group in new groups. Explain their interaction to the group. Next, categorize the interactions into 2 groups, then think of another grouping. Decision making: How can you find out which person’s gut microbes are ‘better’? Hypothesize the type of person who would have ‘better’ gut microflora. Options: gender, diet, geography Also, need to define ‘better’. Know several examples of symbiotic relationships in nature Animals have a microbiome, and it is critical for life. Explain what gut microflora is, and what it does for the host. Competition between organisms plays a role in the composition of the community. Understand the benefits we get from microbes, as well as the benefits microbes get from us. LearnSmart reading Intro to symbiosis lecture Germ-free animals Termites Defining features Gut microflora lecture Rumen microbiology Dirty jobs video Human microbiome Competition in communities lecture What is a community? Communities – biofilms video Cooperation between microbes Human microbiome influences articles ‘You are your microbes’ video

2. interactions Commensal Helpful – Nutrients – Vitamins – Occupy space Competition – Nutrients – Space Harmful – Infection – Toxins – Damage Opportunists – Broken barriers – Skin – Mucus membranes – Entry to new area Effects on host – Nutrients – Hormones – Gene regulation – Immunity Antagonism Practice – Germ-free animal problems Effects on microbe – Shelter – Food – Consistent conditions

3. Students will understand that w hile microbes can harm us, we require interactions with them to survive.. Learning outcome (ATA SWBAT) Taxonomy categoryLearning activitiesFormative assessments Summative assessment 1. Understand that animals have a microbiome, and it is critical for health. Understand / applyReading/ lecture LearnSmart analytics Defining features matrix 2. Discuss several examples of symbiotic relationships in nature Apply/ analyzeJigsaw Diagrams, categorized 3. Understand what a microbial community is. analyzeLecture/ biofilm video Approximate analogies activity 4. Explain what gut microflora is, and what it does for the host. understand Lecture/ you are your microbes video Explain to your mom 5. Competition between organisms plays a role in the composition of the community. analyzelectureApprox analogies 6. Cooperation between microbesanalyzeLecture/ biofilm videoApproximate analogies 7. Understand the benefits we get from microbes, as well as the benefits microbes get from us. understand Lecture/ you are your microbes video Explain to your mom 8. Design an experimental scheme to study microbes in ‘natural cooperatives’ apply/ analyze/ evaluate/ create Decision making Discussion and answers to questions/ hypothesis draft/ experimental designs Experimental design project. 9. Hypothesize the response of the body to a microbe. createLecture/ case studies Problem recognition Answers to questions 10. Describe several ways that the human microbiome influences the host. understandLecture/ case studiesProblem recognition Answers to questions

4. MondayTuesdayWednesdayThursdayFriday Saturday / Sunday LearnSmart reading 11.1 IL Symbiosis, gut micro, videos Explain to a family member Whose are better? Case studies In class Out of class Week 1 Analytics Diagrams Approx analogies Hypothesis and experimental plan Case study questions