1. Hallym University, prof. J.M. Ahn What is Biomedical Engineering? 안 재 목 (J.M. Ahn) 한 림 대 학 교 정보통신공학부

2. Hallym University, prof. J.M. Ahn Areas of research Cellular and Molecular eng., Tissue Eng. –cellular bioelectricity Diagnostic and Therapeutic EngDiagnostic and Therapeutic Eng. Technology for health

3. Hallym University, prof. J.M. Ahn Areas of Biophysics BIOPHYSICAL THEORY AND MODELING, CHANNELS, RECEPTORS, AND TRANSPORTERS ELECTROPHYSIOLOGY MEMBRANES MUSCLE AND CONTRACTILITY NUCLEIC ACIDS PHOTOBIOPHYSICS PROTEINS SPECTROSCOPY, IMAGING, OTHER TECHNIQUES CELL BIOPHYSICS

4. Hallym University, prof. J.M. Ahn Cellular Bioelectricity Transmembrane electrical phenomena in nerve cells in the brain nonlinear dynamical systemsnonlinear dynamical systems analysis and modeling I think, I eat, therefore I am

5. Hallym University, prof. J.M. Ahn PC-based Brain Interface Direct Brain Interface Computer

6. Hallym University, prof. J.M. Ahn Data acquisition Ground Isolation ECoG recording up to 30 channels 0.01~100 Hz EMG or switch

7. Hallym University, prof. J.M. Ahn Cellular biophysics Exocytotic membrane fusion Bioeffect Bioeffect exposed to EMFBioeffect exposed to EMF model secretory cells cellular messengers interaction of cell- surface receptors

8. Hallym University, prof. J.M. Ahn Protein biophysics Proteins acquire their unique function through a specific folding of the polypeptide chain. The stability of proteins or their resistance against unfolding is typically investigated by chemical or thermal denaturation. Domain unfolding dZ Elasticity ABC A B C

9. Hallym University, prof. J.M. Ahn Volume conductor models torso heart

10. Hallym University, prof. J.M. Ahn Electrophysiology : Muscle & contractility Sinoatrial node cell Ventricular cell Neuron cell Diagnostic Engineering ECG

11. Hallym University, prof. J.M. Ahn Medical Device Paradigm On-BoardDiagnosisOn-BoardDiagnosis Recording,AssistanceRecording,Assistance Determine if the patient is ill Requires some form of treatment Assist the specialist with patient diagnosis Avoid observer variability

12. Hallym University, prof. J.M. Ahn Functional Electrical Stimulator(FES)

13. Hallym University, prof. J.M. Ahn Musculoskeletal Research function and material properties of tissuesSports medicine, injury prevention and repair/reconstruction, basic science projects to determine the function and material properties of tissues, and structural testing of bones and joints

14. Hallym University, prof. J.M. Ahn Computational Motor Control Anatomical structure and muscle power of the musculoskeletal system Adaptations in neural control strategies

15. Hallym University, prof. J.M. Ahn Therapeutic Engineering (coronary artery occlusion)

16. Hallym University, prof. J.M. Ahn Artificial heart

17. Hallym University, prof. J.M. Ahn Artificial Heart-continued Cardiac pacemaker Implantable cardiac defibrillator(ICD)

18. Hallym University, prof. J.M. Ahn Totally implantable artificial heart The ABIOMED total artificial heart consists of two main pumping chambers, an actuator system, batteries and control electronics.

19. Hallym University, prof. J.M. Ahn Korean total artificial heart <Configuration> 1) moving actuator - brushless dc motor - brushless dc motor 2) right ventricle=right sac 3) left ventricle=left sac - segmented - segmented polyurethane polyurethane 4) Interventricular space occupied by lubricating occupied by lubricating silicon oil and air silicon oil and air

20. Hallym University, prof. J.M. Ahn Power Processing Unit PowerProcessingUnit Telemetry Energy Transmission RechargeableBattery RechargeableBattery Telemetry Outside Body Inside Body Skin ImD RF

21. Hallym University, prof. J.M. Ahn Transcutaneous energy transmission Activeswitch LoadNetwork Driver Rectification Vin=10~20 volts frequency=400 kHz ImplantableDevices DC voltage(5,12,24V) Coils

22. Hallym University, prof. J.M. Ahn Energy Real system

23. Hallym University, prof. J.M. Ahn RF coils EXTERNAL COIL INTERNAL COIL VERTICAL DISTANCE = 0.8 ~ 2 cm 4.5 cm

24. Hallym University, prof. J.M. Ahn RF coil coupling Skin thickness 0.8 ~ 2 cm External Coils Internal Coils

25. Hallym University, prof. J.M. Ahn Animal experiments External coils Artificial Heart

26. Hallym University, prof. J.M. Ahn In vivo performance 9030105 watts 100 50 75 Efficiency(%)

27. Hallym University, prof. J.M. Ahn Electronic stethoscope combined with ECG heat coil

28. Hallym University, prof. J.M. Ahn Pulse oximetry & ES Pulse oximetry 헤드폰 chestpiece

29. Hallym University, prof. J.M. Ahn CONCLUSIONS APPLICATION TO PHYSIOLOGICAL SYSTEMS FOR THE ADVANCEMENT OF SCIENTIFIC KNOWLEDGE AND IMPROVEMENT OF CLINICAL PRACTICE