1. The Bruker ICP-MS – a Versatile Tool for Sensitive and Interference Free Analysis of Different Matrices
Title of sales presentation – Remarks: „Bruker Confidential“ needs to be erased (slide master!) for external use.

2. Applications for ICP-MS
Environmental
Waters Analysis
Drinking water
Effluents from industrial sites
Sea Water Analysis
Most elements at ultra-trace levels
Soil, Sediment and Land Site Contamination
Trace and toxic elements
Samples digested/leached in acids
Agriculture and Food
Food safety
Toxic elements Pb, Cd, Hg, Cr, As
Plants, Herbs
Fertilizer, Animal Feed
Food, Fruits and Beverages
Toxic, essential and macrominerals
Meats, Crops, Milk, Tea, Wine, Juice

3. Applications for ICP-MS
Clinical research
Bloods, Serums, Urine, Tissues
Complex matrix, viscous
High levels of C, S, P, Na, Mg, Fe, Cl
Trace, Toxic and Nutritional
As, Pb, Tl, Th, Cd, Cr
Se, Cu, Mn, Au, Pt
I, Hg
Geochemical Applications
Soils
Digestion required
High TDS & matrix
Rocks, Ceramics, Fly ash, Coal
Possibly crushed & fused
Al, Ca, Fe, K, Mg, Na, S, Cr, Cu, Ni, Pb, Zn
Minerals and precious metals prospecting
Gold and the PGEs (Pt, Pd, Rh, Ru, Ir and Os)
Rare earth elements at trace levels

4. Applications for ICP-MS
Other Applications
Industrial
Cement and building products
Nuclear
Cooling water (10B/11B)
Isotope ratios
Forensic
Gun powder residues
Gold Characterization
Purity
Element fingerprinting
to infer the origin of the material

5. Diagram of ICP-MS Operations
Vacuum
Sample
Detector
Mass Analyser
Ion Source
Data Process

6. ICP-MS Sample Preparation – Introduction
Liquid samples
(dilute), run
Suspensions
filtrate/digest, run
Viscous samples
dilute, run
Powders and Solids
digest (microwave), run
S.G.
P.G.
A.G.
N.G.
Sample Flow
To Waste
P.G. – Plasma Gas
A.G. – Auxiliary Gas
N.G. – Nebulizer Gas
S.G. – Sheath Gas

7. High Performance Ion Optics
90 degree ion mirror
Increased efficiency and sensitivity
Reduced contamination
Improved long term signal stability
Simplified operation
Maintenance-free
Curved entrance rods
Double off axis quadrupole
Removes excited neutrals before they reach the quadrupole
Lowest possible backgrounds
Better detection limits

8. Ion Optics – working principle
Ions
Neutrals
Photons 1 2 3 4 5 6 7
Extract lens-1
Extract lens-2
Extract lens-3
Corner Lens
Mirror lens (L, R, B)
Entrance Lens
Entrance Plate

9. Bruker ICP-MS - Low Noise Quadrupol1 1
Entrance lense
S-shaped pre-Quadrupol 2 2 3
3 MHz Quadrupol 3

10. Schematic of the Detector Operation
Control Section
Signal Output
Quadrupole
Gain Control
Ion to e-Conversion
Amplification e- +
The detector coverts ions into electrical pulses. Adjustment of voltage applied to control dynode provides attenuation of final output signal.

11. 9 Orders Linear Dynamic Range10
ppt
100 1
ppb
ppm
0.1 %
Normal-sensitivity-
Mode
1 MHz
1 GHz
Ca-Conc.
K-ConC.
U - 1 ppb
Cd - Limit TVO
5 ppb

12. Interference Management The CRI Technology
Title of sales presentation – Remarks: „Bruker Confidential“ needs to be erased (slide master!) for external use. 12 12

13. Spectral Interferences in ICP-MS
CRI reduce/remove common plasma based interferences
Element Isotope Interfering ion
Calcium 40Ca 40Ar+
Vanadium 51V 16O35Cl+
Chromium 52Cr 40Ar12C+
Iron 56Fe 40Ar16O+
Arsenic 75As 40Ar35Cl+
Selenium 78Se 40Ar38Ar+
80Se 40Ar40Ar+

14. CRI – Collision Reaction Interface
Operates on the plasma, NOT the ion beam
Uses similar chemistry to collision cells, but under very different conditions of temperature and pressure

15. CRI Simple and Effective
Simple collision and reaction gases (He and H2) are injected into the plasma as it passes through the cones…
Interferences are attenuated, allowing lower detection limits and better accuracy for ‘difficult’ elements.
e.g. As, Se, V, Cr, Ca, Fe, etc.

16. New and Improved CRI II Universal Mode
CRI in ‘All He mode’ for all elements
Faster and simpler methodology
Caters to future USEPA requirements
Nitrox 500 for online addition of N2 -improves As & Se detection limits
Multi-mode
Using optimal CRI conditions for more complex matrices (H2, He)
Clinical, semi-conductor, geochemical, etc…

17. Fe-analysis in Ca-matrix with CRI - H2 CaO (and ArO) interference on Fe

18. Bruker Quantum, ICP-MS Software
Integrated LC-ICP-MS
Integratede LA-ICP-MS

19. Aerosol dilution
Minimizes sample preparation by extending matrix tolerance of ICP-MS
For samples containing 0.2 to 4% Total Dissolved Solids
Eg. seawater contains ~3.5% TDS
Inline dilution via detuning of nebulizer efficiency & sheath gas dilution effect
Achieve 10-fold dilution without additional sample prep
Suitable for seawater, metals and mining, high TDS effluents

20. Auto-optimization of Aerosol Dilution
Two dilution settings
Low dilution
5-fold dilution
Samples with ~1-2% TDS
Metals and mining, effluents
High dilution
10-fold dilution
Samples with ~2-4% TDS
Seawater
5-fold reduction in oxide interferences
Rare Earths

21. Typical Analysis Settings
L/min
L/min
More efficient nebulization
Low gas dilution

22. Aerosol Dilution Settings
L/min
L/min
Less efficient nebulization
High gas dilution
Followed by automatic optimization of ion optic settings

23. Seawater Analysis using Aerosol Dilution

24. New! Nitrox 500 Gas Accessory
Add N2 or O2 online to auxiliary gas
0-500 mL/min, computer controlled
N2 for improved sensitivity and reduced interferences on As & Se
3-4 times sensitivity improvement
lower DL’s for enviro applications
O2 for organic solvents
petrochemical applications

25. Summary Unmatched Sensitivity All-digital Detection System
High efficiency ion mirror
Excellent detection limits
Attractive to laser ablation and niche application markets
Only detector to offer 109 working range in pulse-counting (digital) mode.
No cross-calibration of digital-analog modes required
Simplified Interference Management
Low Maintenance Design
Innovative Collision-Reaction Interface (CRI)
Removes interferences at plasma
interface, not the ion beam
Simplified setup and maintenance
Hollow ion mirror design requires no cleaning
No need for additional cleaning / replace of interference management technology 25 25

26. www.bruker.com This is the last slide
For research use only. Not for use in diagnostic procedures.