1. Our Solution Use antifouling polymer coating Recesses Leaflets

2. Patent Search Novelty of the design FDA requirements Patent Search Mechanical Valve Polymer Coating Mechanism

3. Prosthetic Heart Valve with Surface Modification Patent No. : US6764509 Issue date Jul 20, 2004 Owned by Medtronic Coating with a chemical substance to prevent:  Thrombus formation  Mineralization Does not include zwitterionic carboxy betaine or its derivatives (CB-OH)

4. Plasma Process Surface Modification onto Pyrolytic Carbon Patent Number: 637228 Issue Date: Apr 16, 2002 Owned by Medtronic Inc Purpose: Adhesion of the polymer and/or bioactive compound on pyrolytic carbon Plasma deposition of a silicon and oxygen film

5. HridhayCoeur Patent 1.A mechanical heart valve comprising titanium body, pyrolytic carbon flaps and Dacron sewing cuff, with modifications that make it have negligible immuno-rejection by the body. 2.The heart valve of claim 1, wherein the valve is a bi-leaflet mechanical heart valve. 3.The heart valve of claim 1, wherein the pyrolytic carbon component is modified by coating with anti-fouling polymers. 4.The heart valve of claim 3, wherein said modification method is done prior to implantation and reduces the risk of hemolysis, infection and/or thrombogenesis to the implant. 5.The heart valve of claim 3, wherein anti-fouling polymer is deposited via the plasma deposition process. 6.The heart valve of claim 3, wherein the polymer used is zwitterionic carboxy betaine (CB-OH). 7.The polymer of claim 6, wherein CB-OH and/or any other modification or derivations of CB-OH are used to achieve same or similar properties. 8.The polymer of claim 7, wherein the polymer is added to and/or coating is done on any type of implant. 9.The polymer of claim 7, wherein the polymer is added to and/or coating is done partially on any type of implant. 10.The polymer of claim 7, wherein the polymer is added to and/or coating is done on any type of valve. 11.The polymer of claim 7, wherein the polymer is added to and/or coating is done partially on any type of valve.

6. HridhayCoeur Patent “The coating of mechanical heart valve with zwitterionic carboxy betaine (CB-OH) or its derivatives to increase antithrombotic or antimicrobial properites and hence minmize immuno-rejection by the body.”

7. Medtronic Competitive Market  Need for differentiation Minimize non-specific protein adsorption Improve blood compatibility We have the answer! Medtronic Open Pivot Mechanical Heart Valve

8. Benefits To Medtronic Novel Technology Market leadership Wider pool of knowledge and skills Business contact To HirdayCoeur Capital Reputation