1. Enabling Technology Innovation in Healthcare and the Life Sciences Steven Locke, MD Course Co-Director Mirena Bagur Course Co-Director HST.921 HST.922 HST.923 HST.924 Spring 2014 Bryan Bergeron, MD Assistant Directors Chandrika Samarth, MBA Course Fellow

2. Agenda Course Mission Statement Course Overview –Faculty, Students, and Sponsors –Lectures –Tutorials –Practicum – Projects and Final presentations FAQs –Registration & Credit Q&A Contact

3. HST.921: Enabling Technology Innovation in Healthcare and the Life Sciences http://hst921.org Lectures: Tuesdays, 4:00-5:30pm Tutorials/Lab: Tuesdays, 5:45-7:00pm Place: MIT E51-151 Classes start Tuesday, Feb 4th

4. Mission Statement To empower students to: critically analyze a current -- or future -- problem in health care and the life sciences, and working in teams, develop a novel solution using information technologies.

5. Course Faculty Steven Locke, MD Research Psychiatrist, Division of Clinical Informatics Beth Israel Deaconess Medical Center Associate Clinical Professor of Psychiatry, Harvard Medical School Affiliate Faculty, Division of Health Sciences and Technology, MIT Bryan Bergeron, MD President, Archetype Technologies Assistant Professor of Health Sciences and Technology, MIT Chandrika Samarth, MBA Course Fellow Director of research at a grant funded start up Mirena Bagur CONTeXO Group The Capital Network MIT Enterprise Forum MTLC Affiliate Faculty, Division of Health Sciences and Technology, MIT

6. Industry Mentors Winfried A. Burke –CEO, iGetBetter; serial entrepreneur/software Francis X. Campion, MD –Vice President of Clinical Affairs, Alere Analytics –Diplomate, Clinical Informatics, American Board of Preventive Medicine Renu Chipalkatti –Executive Director, Healthcare and Incubation @ Verizon Enterprise Solutions Greg Erman –CEO, lecturer, serial entrepreneur, med devices Mark Hauser, MD –OnSite Psychiatric Services

7. Expert Panelists Daniel Sands, MDChange Agent in Doctor Patient Comm Lynne DunbrackAnalyst, IDC – Health Industry Insights David Judge, MDCIMIT Craig Schneider, Ph.DMass Health Data Consortium Al Lewis, JD Founding President, DMAA Christian CortisPartner, ATVentures Anita Goel, MD, Ph.DCEO, Nanobiosym Deb TheobaldCEO, VECNA Richard AndersInvestor, Mass Medical Angels Peter LomedicoJuvenile Diabetes Foundation Josh FeastCEO, Cogito Health Stan NowakCEO, SilverLink Michael LemnitzerPhilips Telehealth

8. Student Comments "HST921 was an incredible experience for me. It was an excellent opportunity to meet face-to-face with recognized leaders in the field who are working on really difficult problems and willing to mentor students who are interested in getting involved. HST921 is both an industry overview and an entrepreneurship class in one - which was exactly what I was looking for.” -- Krishna Yeshwant, Harvard MD/MBA 2009 2008 MIT $100K Competition winner and 2008 Harvard Biz School Competition winner

9. Students Harvard HMS HSPH HBS KSG HGSE FAS HLS Affiliated hospitals MIT HST Computer Science Electrical Engineering Biomedical Engineering Media Lab Sloan School

10. Sample lectures & tutorials TitleFacultyTutorial/Practicum Welcome & Course Introduction Lecture: A Perspective on HIT and Innovation Course FacultyProjects’ descriptions and overview Industry Overview: The Future of HealthcareSteven Locke, MD + expert panelProject presentations Federal Policy as a Driver for HIT InnovationKaren Bell, MD, MPHProject Assignments Medical NetworkDaniel Sands, MD, MPHTutorial: Makings of a team Innovation in an Enterprise/IntrapreneurshipJohn Glaser, PhDDefinition of Elevator Pitch Key Elements of Business Plan Classroom simulation: product design processBryan Bergeron, MDSimulation debrief Population Management and Patient Engagement in Self-Care Steven Locke, MD + expert panelPractice elevator pitch Investors’ View of StartupsEugene Hill, MBADeliver “elevator pitch” Consumers in Healthcare: Patient Power, Medical Home, Patient-Centric Care Bryan Bergeron, MD + expert panelMentor/Team Session Starting Up: Funding Sources for For-profit and Social Entrepreneurship expert panelMentor/Team Session Innovation Examples in Various CompaniesExpert panelMentor/Team Session Entrepreneurs PanelSteven Locke, MD + entrepreneursFinal Team Q&A w/Mentors Project Presentations IStudent teams Project Presentations IIStudent teams

11. Projects & Final Presentation

12. Group Design Projects Student driven Corporate partner driven Multidisciplinary teams Tracks –Design, Business, Marketing, Trials Class exercises (design, elevator pitch) Group final presentations and paper

13. Common Elements 1.Objective of the group project 2.Proposed product or service solution 3.Industry summary 4.Analysis o Problems with current solutions o Competitive analysis o Porter model o Evaluation of macro-industry forces o Micro-stakeholder analysis 5.Interaction diagrams 6.Reflection on cost, quality, and access

14. Project Track Selection Track 1: Marketing Analysis Track 2: Business Plan Track 3: Product Design Plan Track 4: Clinical Trial/Product Evaluation Each team chooses two out of four

15. Market Analysis and Plan 1.Market Background 2.Future Directions of Market 3.Market Size/Forecast 4.Customers/Customer Segmentation 5.Target Market Segments 6.Product Description 7.Pricing 8.Promotion 9.Sales and Distribution Strategy

16. Business Plan 1.Partnering 2.Staffing Plans 3.Advisory Board 4.Risk Management ( analysis of specific risks and address various scenarios ) 5.Financial Projections and Resources Required 6.Near Term Milestones and Expenses 7.Long Term Projections

17. Product Design The Product 1.Product Definition and Goals 2.Product Requirements/ Specifications 3.Expected Product Lifecycle 4.Product Add-ons, Third Party Tool Sets 5.Follow-on Products User Profile 1. Job Description 2. User Skills, Knowledge and Education 3. Work Style 4. Concerns 5. Wants 6. Requirements 7. Work Environment

18. Clinical Trial 1.Rationale 2.Objectives 3.Study design and hypotheses 4.Participants 5.Intervention 6.Primary and secondary endpoints 7.Sample size (optional) 8.Anticipate time frame for study completion 9.Data collection; sub-protocols, intervals, encounters, events 10.Analysis

19. Sample Student Projects Student provided project: MedGenuity - Engineering a Premium Platform for Providers Dossia Consortium -Evaluating the Proposition for PHR: Strategic Analysis & Product Evaluation Intel - Medication Adherence 2.0 Insurance Company - Exploration of social networking technologies to engage health care consumers Symantec - Utilizing the latest technology to easily and securely view & share diagnostic images and reports J&J - Empowering Consumers and Physicians via Consumer-led Social Media Networks Healthways - Improving Physician Engagement Through Technology Careplace - Online Health Consumer Empowerment, Advocacy, and Support Technology Opportunities in Healthcare for the Baby Boomer Generation Computer-Assisted Disease Management to Improve Outcomes in Diabetic Patients

20. Sponsors: Corporate Partners Other Participating Organizations Archetype Technologies, Inc. The CONTeXO Group iHope, LLC

21. Student Comments “HST.921 unified business, science, and medicine with a set of uncommon learning objectives, focused on developing skills on how to pursue ideas and get things done in the real world. The curriculum was phenomenal. Best of all, I met some very talented classmates and teachers with whom I share ideas on a frequent basis. Two thumbs up!” Eugene Chan, MD Physician-Innovator-Entrepreneur Director/The DNA Medicine Institute

22. FAQ’s Project selection Required readings Required paper School-specific credit Work load Attendance Professional standards Course auditing

23. Registration and Credits MIT Students Go to WebSIS (student.mit.edu) and follow links to pre- registration. Add HST.921 and HST.923 to your pre- registration.student.mit.edu Harvard Students https://crossreg.harvard.edu/OASIS/CrossReg/ Cross-Registration Credit Calculator https://crossreg.harvard.edu/OASIS/CrossReg/credit.jsp

24. GradeHMSHSPHKSGHBSMIT Lecture HST.921P/F22.5 0.5 N/A*9 HST.922Ordinal22.5 0.5 N/A*9 Tutorial HST.923P/F22.5 0.5 N/A*3 HST.924Ordinal22.5 0.5 N/A*3 Full Credit45 1 N/A*12 Half Credit22.5 0.5 N/A*9 Registration Credits *can arrange as independent study for credit

25. Questions and Discussion

26. Workshop https://www.leapmotion.com/ https://www.leapmotion.com/

27. Workshop = 45 minutes Two teams Each define their idea of how LeapMotion can be used in healthcare or life sciences – 20 min brainstorm Answer these questions: –What does the product do? –How will you make money on the product? –How will you get the money to create a business that will develop the product? One member of the team presents the group’s answers in about 5 min Follow-up conversation – 20 min

28. HST921: Contact Info Mirena Bagur –617-835-5019 –mirena.bagur@gmail.com