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Extranodal Lymphoma: Waldeyer’s Ring Lymphomas, primary Muscle Lymphoma Sinus Lymphomas , Bone.

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Presentation on theme: "Extranodal Lymphoma: Waldeyer’s Ring Lymphomas, primary Muscle Lymphoma Sinus Lymphomas , Bone."— Presentation transcript:

1 Extranodal Lymphoma: Waldeyer’s Ring Lymphomas, primary Muscle Lymphoma Sinus Lymphomas , Bone Lymphoma Salivery Gland Lymphoma, Pancreatic Lymphoma Thyroid Lymphomas , Cardiac Lymphomas Nasal and nasopharyngeal Lymphomas Adnexal lymphomas, Uterine & Cervical Lymph. Ocular Lymphomas , Pulmonary Lymphomas Central Nervous Lymphomas Prostatic Lymphoma Gastric Lymphoma , Small Bowel Lymphomas Large Bowel and Anorectal Lymphomas] Hepatic Lymphomas, Breast Lymphomas Splenic Lymphoma Bladder Lymphoma Renal Lymphomas , Testicular Lymphoma Dr.Azarm

2 Extranodal means 'beyond nodal' Sites
are identified by the following notation:    Lymph nodes    Liver (hepatic)   Lung   Bone marrow    Spleen    Pleura (lung)    Bone    Skin (dermis) Dr.Azarm

3 Fevers (nonspecific) Chills Unexplained weight loss Night sweats
Nonspecific Symptoms of lymphoma may Include the following: Fevers (nonspecific) Chills Unexplained weight loss Night sweats Lack of energy Itching Dr.Azarm

4 Dr.Azarm

5 HIV-associated primary non-Hodgkin's lymphoma of ovary.
Ovarian Lymphoma: Primary ovarian lymphoma associated with Meigs' syndrome. Primary ovarian lymphoma manifesting with severe hypercalcemia HIV-associated primary non-Hodgkin's lymphoma of ovary. Primary Ovarian Non H L with Autoimmune Hemolytic anemia.

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7 PRIMARY GASTROINTESTINAL lymphomas constitute 5% to 10% of all gastrointestinal tumors.
Twenty percent to 30% of gastrointestinal lymphomas, or approximately 5% of peripheral non-Hodgkin’s lymphomas (NHL), in general, are primarily located in the intestine and differ from gastric lymphomas in clinical features, pathology, treatment, and prognosis.

8 Primary malignant lymphoma of the thyroid
Accounts for <5% of all thyroid malignancies and is primarily treated with chemotherapy and external beam radiation. With the advent of modern immunophenotypic analyses, fine-needle aspiration (FNA) can potentially obviate the need for surgical procedures

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10 Testicular lymphoma Testicular lymphoma is almost always of an aggressive histologic subtype, usually diffuse large B cell type. In contrast to other patients with localized large cell lymphoma Testicular lymphoma is a rare extranodal presentation of non-Hodgkin lymphoma. The risk of extranodal recurrence is high, especially in the central nervous system

11 chemotherapy: CHOP+ rituximab
Testicular lymphoma the recommended treatment for all stages of testicular lymphoma is a full course of chemotherapy as for advanced disease chemotherapy:  CHOP+ rituximab

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13 Liver Lymphoma: Nine out of 10 patients with primary lymphoma of the liver presented in a manner that did not suggest a tumour. The initial diagnoses were chronic active hepatitis in three cases and "granulomatous cholangitis", inflammatory pseudotumour, and anaplastic carcinoma in one case each

14 Peripheral T-Cell Lymphoma
Arising in the Liver

15 pulmonary Lymphoma.

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18 Mediastinal Lymphoma

19 pulmonary Lymphoma.

20 Mediastinal Lymphoma

21 Primary cardiac lymphoma
Patients may present with dyspnea, congestive heart failure, chest pain, epigastric pain, pericardial tamponade, conduction abnormalities, or arrhythmia. Acute myocardial infarction may be simulated by diffuse myocardial infiltration.

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23 Primary lymphoma of bone

24 Primary lymphoma of bone

25 CNS lymphoma may affect people whose immune system is not working properly.
for example, after organ transplants, or in people with HIV

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28 The most common site for a CNS lymphoma is the cerebrum
:.primary CNS lymphoma The most common site for a CNS lymphoma is the cerebrum                                              The areas of the brain

29 Cutaneous T-cell Lymphoma:
Malignant Lymphoma bone marrow invasion. Malignant Lymphoma skin invasion (Mycosis F). Sezary syndrome.

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31 MALT lymphoma: an indolent (commonly called low grade) type of B-cell non-Hodgkin lymphoma MALT lymphoma most frequently arises within this type of lymphoid tissue after it has accumulated as part of a reaction to an infection or inflammation. MALT lymphoma is the third most common type of non-Hodgkin lymphoma In GI. It is associated with Helicobacter pylori infection.

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33 Sinus Lymphomas

34 Renal lymphoma Renal lymphoma has an insidious clinical presentation that occurs late in the course of the diseaseIt can present in many ways, however the most common are primary tumors presenting single or multiple nodules, or that involve the kidney, either in a hematogenic dissemination form or through a contiguous retroperineal disease

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38 Primary renal Iymphoma

39 CNS lymphoma The symptoms and signs of CNS lymphoma are often related to increased intracranial pressure ( ICP ), e.g. headache, mental change, or focal neurological deficits Notably, only 5% of CNS lymphoma patients experienced inner ear symptoms such as vertigo, tinnitus or progressive hearing loss [9]. Thus, clinically, vertigo accompanied by progressive hearing loss rarely occurs in CNS lymphoma.

40 Splenic Lymphoma

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43 Primary Nasal Lymphoma

44 Salivery gland lymphoma:
Multiple maxillofacial extranodal sites of soft tissue mass with the presence of non-necrosis and uneven margin should be considered as the characteristic sign of NHL disease in the head and neck

45 Salivery gland lymphoma

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