1. Cardiac Pathology: Valvular Heart Disease, Cardiomyopathies and Other Stuff

2. Blood Vessels Heart I Heart II Cardiac Pathology Outline

3. Blood Vessels Heart I Heart Failure Congenital Heart Disease Ischemic Heart Disease Hypertensive Heart Disease Cardiac Pathology Outline

4. Blood Vessels Heart I Heart II Valvular Heart Disease Cardiomyopathies Pericardial Disease Tumors Cardiac Pathology Outline

5. Blood Vessels Heart I Heart II Valvular Heart Disease Cardiac Pathology Outline

6. Stenosis and/or insufficiency Stenosis: failure to open Insufficiency: failure to close Murmurs: blood ejects rapidly through the stenosis Valvular Heart Disease

7. Part of aging process Results in – increased LV pressure – LV hypertrophy – Relative ischemia Angina, CHF, or fainting (syncope) Calcific Aortic Stenosis

8. Calcific aortic stenosis

10. Common (5% of adults in US, F>M) Ballooning of mitral leaflets back into the upper heart chamber Myxoid/mucoid change within leaflet Pathogenesis unknown Most patients asymptomatic – May have headaches, fatigue, chest pains Mitral Valve Prolapse

11. Mitral valve prolapse

12. Rheumatic Valvular Disease Rheumatic fever: systemic inflammatory disease occurring a few weeks after strep throat Valves (esp. mitral) become scarred Consequence: stenosis (± regurgitation)

13. Body makes antibody to strep bug that cross- reacts with antigens in heart and joints 2-3 weeks after strep throat, patient gets: migratory polyarthritis pericardial friction rub, arrhythmias Chronic disease can reappear decades later mitral stenosis, left atrial enlargement, thrombi increased risk of infective endocarditis Long term prognosis variable Rheumatic Fever

14. vegetationsAschoff bodypericarditis Strep throat Antibody production Antibody cross-reaction with heart

16. Mitral stenosis with commissural fusion

17. Microbial invasion of endocardium and/or heart valves Acute endocarditis highly virulent bug attacks normal valve half of patients dead within days to weeks Subacute endocarditis low virulence bug colonizes abnormal valve slow onset, long course, most recover Symptoms: fever, flu-like symptoms Complications: septicemia, arrhythmias, renal failure, systemic emboli Infective Endocarditis

18. Infective endocarditis: vegetations on valve

20. Vegetation

22. Infective endocarditis: splinter hemorrhage of nail bed

23. Blood Vessels Heart I Heart II Valvular Heart Disease Cardiomyopathies Cardiac Pathology Outline

24. Diverse group of disorders in which there is intrinsic myocardial dysfunction Lots of causes; some idiopathic Three groups Dilated congestive cardiomyopathy Hypertrophic cardiomyopathy Restrictive cardiomyopathy Non-inflammatory conditions that cause impaired myocardial function Cardiomyopathies

25. Heart dilates, enlarges, and can ’ t contract well Ejection fraction typically falls, ESV and EDV increase = stretching of myocardium Causes viral Alcohol (main cause)/toxin genetic abnormalities peripartum Slowly progressing CHF 70% of patients dead within 5 years Dilated (Congestive) Cardiomyopathy

26. Dilated (L) and hypertrophic (R) cardiomyopathy

27. Massively hypertrophied L ventricle can ’ t fill Cause: mutation in a sarcomere protein gene – Septum enlarges disproportionately Symptoms: atrial fibrillation, CHF, arrhythmia, sudden death Treatment: drugs to promote ventricular relaxation or surgical excision of part of septum Prognosis: about 4% of patients die each year Hypertrophic Cardiomyopathy

28. Sarcomere of cardiac muscle

29. Heart wall is stiff; can ’ t fill during diastole Cause: Idiopathic or secondary to systemic disease (amyloidosis, hemochromatosis, sarcoidosis) Symptoms: shortness of breath, peripheral edema Treatment: not often helpful 70% of patients dead within 5 years Restrictive Cardiomyopathy

30. Blood Vessels Heart I Heart II Valvular Heart Disease Cardiomyopathies Pericardial Disease Cardiac Pathology Outline

31. Pericarditis Secondary (MI, radiation, pneumonia) or primary (infectious) Atypical chest pain Dangers: tamponade, chronic fibrosis Pericardial effusion Serous (CHF), serosanguinous (aortic dissection), chylous (lymphatic obstruction) Outcome depends on stretchiness of pericardial sac Slow = asymptomatic; sudden = catastrophic Pericardial Disease

32. Acute pericarditis

33. Types of Pericardial Disorders Pericardial effusion – The accumulation of fluid in the pericardial cavity Cardiac tamponade – Slow or rapid compression of the heart due to accumulation of fluid, pus, or blood in pericardial sac

34. Blood Vessels Heart I Heart II Valvular Heart Disease Cardiomyopathies Pericardial Disease Tumors Cardiac Pathology Outline

35. Most common: metastatic Heart is a rare site of metastasis Lung cancer, lymphoma most common Primary tumors uncommon Most are benign Most common: myxoma Cardiac Tumors

36. Cardiac myxoma