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Teaching NeuroImages Neurology Resident and Fellow Section © 2013 American Academy of Neurology A 51-year-old woman with triplegia and blindness.

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Presentation on theme: "Teaching NeuroImages Neurology Resident and Fellow Section © 2013 American Academy of Neurology A 51-year-old woman with triplegia and blindness."— Presentation transcript:

1 Teaching NeuroImages Neurology Resident and Fellow Section © 2013 American Academy of Neurology A 51-year-old woman with triplegia and blindness

2 51-year-old woman was treated with interferons and glatiramer for relapsing- remitting multiple sclerosis over 20 years Continued to have recurrent attacks of optic neuritis (ON) and transverse myelitis (TM) leading to bilateral blindness and triplegia despite treatment Vignette Braksick et al. © 2013 American Academy of Neurology

3 A CB Braksick et al. Imaging A © 2013 American Academy of Neurology

4 Neuromyelitis optica was ultimately suspected and confirmed by detection of aquaporin-4 autoantibodies Even in the presence of MS-type lesions on MRI, NMO should be considered in patients with recurrent ON and TM MS-directed immunomodulatory medications are not effective and may be harmful when aimed at NMO Braksick et al. Advanced Neuromyelitis Optica © 2013 American Academy of Neurology


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