1. Welcome to the Molecular Medicine course!

2. Registration General information Over-arching goals Roll call Course contents Information about KS library Coffee Course evaluation HT 2011 Study design - research application + presentations Seminar assignment Final examination Molecular Medicine - from bed to bench

3. Course leader: Rachel Fisher 08-517 732 45rachel.fisher@ki.se Deputy course leader: Ewa Ehrenborg 08-517 761 91ewa.ehrenborg@ki.se Teaching assistant: Louisa Cheung 08-517 732 21 louisa.cheung@ki.se Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, L8:02 Course administrator: Eva MacDonald Department of Medicine, Unit for Internal Medicine, Karolinska University Hospital, A3:02 08-517 716 33eva.macdonald@ki.se Office hours daily 8.00am - 3.00pm

4. Over-arching goals To integrate previously gained knowledge To stimulate team work To analyse, evaluate and interpret raw data To design a study and write a research application To provide “real life” experience

5. Roll call

6. Course set up Lectures usually 9am – 3pm (check venue!) Labs/demonstrations/seminars usually in groups Time scheduled for group work Seminar assignment Presentation of group work (research application) at end of course Revision time Final written examination: 15 th January

7. Course contents (15 hp/ECTS) Specific areas Circulation, ischemia, metabolic syndrome, diabetes Respiration, asthma, allergy Endocrinology Gastroenterology Pathology Clinical immunology / Clinical chemistry Assignments etc. Molecular biology lab Research application Seminar assignment Workshops Revision

8. Course literature Text books from previous courses: physiology, pharmacology, biochemistry, molecular genetics, immunology Articles and links on the web page Lecture summary points (from lecturers)

9. Information about KS library Marie Källberg

10. Lab “Methods in Molecular Biology” Lectures, demos, labs, exam Research plan Seminar assignment Workshops

11. Labs and Demonstrations Lab: “Methods in Molecular Biology – Theory and Practice” 12/11 (introduction) 27-29/11, 4-6/12 (lab) 12-14/12 (analysis + statistics) 9/12 (discussion + review) Angiography demonstration (14/11) Blood grouping lab (15-16/11) Lung/allergy demonstration (20/11)

12. Labs You must bring your own lab coat Compulsory to have a lab coat to perform the labs If you have lost the lab coat you were given when you started the Biomedicine Programme, you can buy a new one (380kr): http://www.g-ess.se/ Tel: 08-449 85 70 (Stuvsta + Bromma) Some labs and demonstrations will be performed in active research labs - show consideration for those who work there

13. Groups Blood grouping Thur 15/11, 13–16 Methods Mol Biol Tue 4/12 Blood grouping Fri 16/11, 13–16 Methods Mol Biol Wed 5/12 Blood grouping Thur 15/11, 9–12 Methods Mol Biol Tue 27/11 Blood grouping Fri 16/11, 9–12 Methods Mol Biol Wed 28/11

14. Course evaluation HT 2011 Good Research application Lab “Methods in Molecular Biology” Seminar assignment Course leaders/administration Mixed Clinical emphasis Blood grouping lab Lung/asthma/allergy demonstration Lecturers Bad Lack of a course text book Some repetition within lectures Too many lectures

15. New for HT 2012 Some lectures + pathology seminars removed Workshops Modified set up for Lab “Methods in Molecular Biology” Place blood grouping lab in context Modified lung/asthma/allergy demonstration Final examination after Christmas Presentation of research applications at end of course

16. Workshops 3 workshops:Atherosclerosis(12/11) Endocrinology(21/11) Diabetes/Metabolism(11/12) Questions/discussion topics handed out in connection with relevant lectures Self-study/discussion + review with teacher Preparation for the exam

17. Evaluation of the course We rely on your feedback to improve the course Please give constructive feedback Evaluation forms (online) Cinema ticket voucher if all evaluation forms completed + submitted!

18. With class representatives Wednesday 21 st November, 12 noon With whole class Thursday 17 th January, 3pm Who are the class representatives? Course councils

19. Forms of feedback feedforward assignments  Research application whole-class feedback  Workshops Research application feedback on seminar assignment & exam Pre-submission guidance and feedback  Research application Workshops Peer-to-peer to edit and redraft  Methods in mol biol reviewing progress with  students Informing about feedback Course councils and evaluations Round-table feedback  Methods in mol biol

20. Course language All literature in English Lectures in English All assignments may be written in either English or Swedish

21. Research application Group assignment Choose a specific issue to focus on Design a research project Write a research application Present the project orally Answer questions Team work Realistic exercise

22. Research application: groups and topics Groups 1-6 each split in 2 12 ”subgroups” of 3-4 people Each subgroup allocated a broad topic Detailed project chosen by the subgroup Discussions with and feed back from topic ”mentor”

23. Research application – broad topics MicroRNA and vascular disease Aneurysm Thyroid diseases Thrombosis and haemostasis Mesenchymal stem cells and bone formation Cell death in metabolism Metabolism and cardiovascular disease Immunological aspects of gastric disease Inflammation in cardiovascular disease Allergy Diabetes and co-morbidities Vascular remodelling 2 topics/group, 3-4 people/research application

24. Research application topic lottery

25. Seminar assignment Handed out at course start Group work / individual assessment Research based aspects, requires independent work Obtain appropriate information - lectures, discussions, web, articles..… Time scheduled to prepare answer Presentation of assignment in seminar format: Groups 4, 5 + 6Wednesday 28 th November Groups 1, 2 + 3Wednesday 5 th December Grading = pass / fail

26. Time in schedule for Groups 1, 2 + 3 to work with seminar assignment

29. Time in schedule for Groups 4, 5 + 6 to work with seminar assignment

32. Examination Final examination: Tuesday 15 th January Grades A-F Questions testing knowledge + understanding

33. Grading of the examination F, Fx, E, D, C, B, A Goal-based assessment Evaluating the level of knowledge obtained not the amount of knowledge F, Fx = fail E = basic pass: identify, describe, list C, D = pass with merit: compare, explain connections, analyse, apply B, A = pass with distinction: theorise, hypothesise, reflect

34. Prestructural F Unistructural Fx Multistructural E Relational C, D Extended abstract B, A One relevant aspect Several relevant independent aspects Integrated into a structure Generalized to new domain

35. To pass the course … The student must obtain a grade of at least E for the written examination (5 hp) The student must also pass –the seminar assignment (3 hp) –the research application (3 hp) –all labs and demonstrations (4 hp)

36. Replacement assignments When compulsory parts of the course are missed, there are replacement exercises If written, these must be handed in by the last day of the course (18 January 2013) Next opportunity for submission = next course (HT2013)

37. Wednesday 21 st November, 1pm Lars-Arne Haldosén Lena Hansson Information about Masters Programme

38. Molecular Medicine: from bed to bench Important clinical contact Translational research Cross-disciplinary “From bench to bed and back again”

39. Please use the web page!