1. F O R I N T E R N A L U S E O N L Y AccelRx Update Business Accumen Class review April 23, 2014

2. F O R I N T E R N A L U S E O N L Y WHAT IS CATAMARAN? Business of Catamaran: Is provider of pharmacy benefit management (PBM) services and healthcare information technology (HCIT) solutions to the healthcare benefit management industry The Company’s product offerings and solutions combine a range of applications and PBM services designed to assist its customers in reducing the cost and managing the complexity of their prescription drug programs. The Company’s customers include organizations in the pharmaceutical supply chain, such as pharmacy benefit managers, managed care organizations, self-insured employer groups, unions, third party health care plan administrators, and state and federal government entities. Up until Healthspring agreeement most conlients were small regoinal companies 2 Confidential, unpublished property of Cigna. Do not duplicate or distribute. Use and distribution limited solely to authorized personnel. © 2013 Cigna

3. F O R I N T E R N A L U S E O N L Y HISTORY 3 Confidential, unpublished property of Cigna. Do not duplicate or distribute. Use and distribution limited solely to authorized personnel. © 2014 Cigna Originally founded as Systems Xcellence in Ontario Canada in 1993 Went public in 1995 on TSX exchange in 2001, it acquired ComCoTec, an Illinois-based software business Went on Nasdaq in 2006 and moved the headquarters to Chicago. Changed name to SXC Health Solution in 2007 Acquired National Medical healthcard Systems and Zynchors in 2008 which doubled the size of the company. SXC purchased private company MedfusionRx, Inc on December 2, 2010 for $100 million. Reasons for the acquisition include an interest in strengthening SXC's position in the specialty pharmacy market and improving cost cutting capabilities in the management of complex conditions and improving supportive care. In 2012, SXC agreed to buy rival Catalyst Health Solutions Inc. in a roughly $4.14 billion cash-and-stock deal. Shortly thereafter, SXC Health Solutions Corp. renamed the company, Catamaran Corp.

4. F O R I N T E R N A L U S E O N L Y LEADERSHIP Mark A. Thierer, 54, –Effective March 9, 2011, Chairman and Chief Executive Officer (CEO) of the Company. –President and Chief Operating Officer of the Company from September 2006 through June 2008 –President and CEO of the Company from June 30, 2008 through March 8, 2011. –President of Physicians Interactive, a former division of Allscripts Healthcare Solutions, Inc. 2003 to 2006. –CaremarkRx, now CVS/Caremark helping to build Caremark into a pharmacy benefits manager and specialty pharmacy company. From 1993 to 2003. Under his leadership: he sought to transform SXC from a pure technology player to an industry-leading full-service provider. When Mr. Thierer joined SXC, revenues were $50 million, EBITDA was $12 million annually and the company market capitalization was $160 million. Since that time, the company has posted a compound annual growth rate of 50% and fifty-fold increase in shareholder value. 4 Confidential, unpublished property of Cigna. Do not duplicate or distribute. Use and distribution limited solely to authorized personnel. © 2013 Cigna

5. F O R I N T E R N A L U S E O N L Y CURRENT HEADLINES NASDAQ: CTRX News: Investors Alert ~ 4/15/14 Shares are showing positive movement after Oppenheimer upgraded by increasing ratings from “market perform” to “outperform” with target of $50 per share. Current at $39-40/per share Forbes 4/3/1 – says stock is oversold. Hit highs of $60 in Aug 13 Facts 4 th largest PBM & Specialty Pharmacy Over 32 million lives served 4,000 employees 5 Confidential, unpublished property of Cigna. Do not duplicate or distribute. Use and distribution limited solely to authorized personnel. © 2013 Cigna

6. F O R I N T E R N A L U S E O N L Y 6 Confidential, unpublished property of Cigna. Do not duplicate or distribute. Use and distribution limited solely to authorized personnel. © 2013 Cigna Catamaran vs. Cigna: 5 Key Drivers

7. F O R I N T E R N A L U S E O N L Y PHARMACY BENEFITS MANAGEMENT VS HEALTHCARE INFORMATION TECHNOLOGY PBM Services: Pharmacy claims management Retail Pharmacy network management Mail Pharmacy claims management Specialty pharmacy claims management Medicare Part D services Benefit design consultation Preferred drug management programs Drug review and analysis Consulting services Data access Reporting and information analysis HIT: RxClaim – prescription drug adjudication RxMax – rebate management systems RxTrack – data warehouse and analysis Zynchros – formulary management tools Pharmacy management system for retail, chain, institutional and mail-order pharmacies Other software

8. F O R I N T E R N A L U S E O N L Y IMPACT TO 5 DRIVERS People- the expansion of the contract from Healthspring which impacts their claim processing, and also impacts all claim processing organizations in Cigna as well as the Home Delivery organization which will cease mail delivery of non specialty products. Assets- it impacts our Horsham and Sioux Falls sites which are mail order fulfillment sites, our claim systems, and our PBM processes. Cash- this is to change the cash flow due to the shift of fulfillment to Catamaran –Project cost is 250 million dollars Profit- drives mail order and other benefit expenses downwards. Growth- change our profits upwards and decrease costs, driving growth 8 Confidential, unpublished property of Cigna. Do not duplicate or distribute. Use and distribution limited solely to authorized personnel. © 2013 Cigna