1. EurocanPlatform A Platform of European Cancer Research Centres for Translational Research Ulrik Ringborg CancerCenter Karolinska

2. Cancer is increasing globally (WHO) 2008 12,4 million new cancer patients2008 12,4 million new cancer patients 2030 20 million new cancer patients2030 20 million new cancer patients 2008 8,3 million deaths2008 8,3 million deaths 2030 12.9 million deaths2030 12.9 million deaths 2008 28 million patients living with cancer2008 28 million patients living with cancer 2030 82 million patients living with cancer2030 82 million patients living with cancer

3. Conclusions from epidemiological analyses Cancer is one of the main chronic diseasesCancer is one of the main chronic diseases Present time trends of improvement of the mortality rate in Europe is not enough to decrease the number of cancer deaths over the next decadesPresent time trends of improvement of the mortality rate in Europe is not enough to decrease the number of cancer deaths over the next decades At the same time, cancer biology & modern technologies offer new possibilities to change the negative trendsAt the same time, cancer biology & modern technologies offer new possibilities to change the negative trends

4. Strategies to decrease the problem Improve preventionImprove prevention Increase cure rateIncrease cure rate Early detection is the bridge between prevention & therapeuticsEarly detection is the bridge between prevention & therapeutics

5. There are, however, two main barriers The intrinsic complexity of cancer Fragmentation (research, clinical care, funding)

6. Fragmentation of cancer research – main reasons Suboptimal translational cancer resesarch  Bridging between basic and clinical research  Bridging between basic and clinical research – early translational research  can be improved – early translational research  can be improved  Bridging between clinical research and implementation and evaluation in the clinical care and evaluation in the clinical care – late translational research  should be improved – late translational research  should be improved Lack of critical mass Eurocan project Eurocan project

7. Critical mass The Comprehensive Cancer Center (CCC) to guarantee the critical mass for clinical care & infrastructures for research & educationThe Comprehensive Cancer Center (CCC) to guarantee the critical mass for clinical care & infrastructures for research & education Integration of care, research and education Integration of care, research and education – the linkage between research & innovation Network of CCCs to guarantee the critical mass for translational cancer researchNetwork of CCCs to guarantee the critical mass for translational cancer research - Patients - Patients - Biological materials - Biological materials - Technological resources - Technological resources - Competences - Competences

8. A key message Collaboration between individual research groups is no longer the solution!Collaboration between individual research groups is no longer the solution! Collaboration between centres is mandatory to guarantee infrastructure support, critical mass of expertise & resources, as well as to improve coordination.Collaboration between centres is mandatory to guarantee infrastructure support, critical mass of expertise & resources, as well as to improve coordination.

9. A European platform for translational cancer research The platform will bring together Comprehensive Cancer Centres with a strong research agenda with basic/preclinical Cancer Centres in an integrated network to collaborate and share resources to optimize the translational process and to increase global competitiveness * Such a platform of centres is the only possible way to reach the critical mass and sustainability that is necessary to innovate and deliver in all areas of cancer research Such a platform of centres is the only possible way to reach the critical mass and sustainability that is necessary to innovate and deliver in all areas of cancer research. * The Stockholm Declaration, Molecular Oncology, 2, 2008

10. EurocanPlatform - NoE Structuring translational cancer research between cancer research centres in Europe  Structuring translational cancer research between cancer research centres in Europe  A structure for innovative translational research on prevention, early detection and therapeutics  A structure for innovative translational research on prevention, early detection and therapeutics  The whole cancer research continuum is covered  The whole cancer research continuum is covered – 16 WPs – 16 WPs * Duration of project – 5 years * Duration of project – 5 years * 12 million euros * 12 million euros * 28 participants from 11 countries * 28 participants from 11 countries

11. PROJECT COORDINATOR Supported by Vice Coordinator Knowledge management Linking all organisational groups Project S&T Advisory Board Project Panels Dissemination Training/Education Ethical Review IPR Technology Transfer Project Steering Committee (1 member/partner) Executive Committee (5 members) Scientific Steering Committee (8 members) Prevention & Therapeutics WPs 2,3,6 (2 coordinators) Technologies WPs 4,5,7,8,9 (2 coordinators) Biorepositories & Clinical Databases WPs 10,11 (2 coordinators) Quality Assurance, Education & Dissemination WPs 12,13,14 (2 coordinators) European Commission Project Office Management & Administration

12. Project Steering Committee Each partner presented by one personEach partner presented by one person WP-leader not representing the partner may be non- voting memberWP-leader not representing the partner may be non- voting member Majority required for decisionMajority required for decision Meetings twice annualyMeetings twice annualy

13. Role of the Project Steering Committee Delegate certain areas of responsibility to the CO or ad hoc groups of consortium members.Delegate certain areas of responsibility to the CO or ad hoc groups of consortium members. Provide overall project management policy.Provide overall project management policy. Make formal decisions on the project & project strategy.Make formal decisions on the project & project strategy. Define, allocate and develop tasks.Define, allocate and develop tasks. Check the progress of the work.Check the progress of the work. Ensure full integration and coordination of the research teams.Ensure full integration and coordination of the research teams. Plan for change and risk management.Plan for change and risk management.

14. Role of the Project Steering Committee, cont Author and implement the Quality Assurance Plan.Author and implement the Quality Assurance Plan. Coordinate the preparation of technical reports.Coordinate the preparation of technical reports. Define the budgets for the individual parts of the project.Define the budgets for the individual parts of the project. Reviewing and proposing budget reallocationsReviewing and proposing budget reallocations Identify potential new project partners.Identify potential new project partners. Permit formal exchanges of information between the partners.Permit formal exchanges of information between the partners. Ensure optimal use of project results.Ensure optimal use of project results. Develop decision-making structures.Develop decision-making structures.

15. Management Co-ordinator Ulrik RingborgCo-ordinator Ulrik Ringborg Vice Co-ordinator Rolf LewensohnVice Co-ordinator Rolf Lewensohn Project Manager Christina von GerttenProject Manager Christina von Gertten Project Administrator Evelyn GöranssonProject Administrator Evelyn Göransson Support – Grants Office KI, Miles DaviesSupport – Grants Office KI, Miles Davies – Legal Council at KI – Legal Council at KI

16. Executive committee Ulrik RingborgUlrik Ringborg Rolf LewensohnRolf Lewensohn Anton BernsAnton Berns Anne-Lise Börresen-DaleAnne-Lise Börresen-Dale Julio CelisJulio Celis Day-to-day responsbilities delegated by the Project Steering Committee Day-to-day responsbilities delegated by the Project Steering Committee

17. Scientific Steering Committee  Anton Berns (chairman)  Alexander Eggermont  Anton Berns (chairman)  Alexander Eggermont  René Bernards  Marco Pierotti  René Bernards  Marco Pierotti  Carlos Caldas  Ulrik Ringborg  Carlos Caldas  Ulrik Ringborg  Julio Celis  Thomas Tursz  Julio Celis  Thomas Tursz

18. Role of Scientific Steering Committee Scientific co-ordination of the projectScientific co-ordination of the project Propose & evaluate research projectsPropose & evaluate research projects Propose sharing of research resourcesPropose sharing of research resources Support the scientific integration in the EurocanPlatformSupport the scientific integration in the EurocanPlatform Deal with legal & ethical issuesDeal with legal & ethical issues Participate in discussions with the industryParticipate in discussions with the industry Prioritize training & exchange of researchersPrioritize training & exchange of researchers Work for research support & sustainabilityWork for research support & sustainability

19. Scientific Advisory Board Hedvig HricakHedvig Hricak Mark IsraelMark Israel John MendelsohnJohn Mendelsohn Richard SchilskyRichard Schilsky

20. A Comprehensive Platform for Translational Cancer Research Increase the interaction between cancer biology & clinical researchIncrease the interaction between cancer biology & clinical research New strategies for research on prevention, early detection & therapeuticsNew strategies for research on prevention, early detection & therapeutics Increase infrastructure support & critical mass overallIncrease infrastructure support & critical mass overall Cover the cancer research continuum including late translational researchCover the cancer research continuum including late translational research Involve methods to measure innovation prevention & cancer careInvolve methods to measure innovation prevention & cancer care

21. Scientific Co-ordination (WP1) and Management (WP16) Quality assurance of centres (WP12), Ethics (WP15), Education (WP13) Research Prevention (WP2) Early detection (WP3) Therapeutics (WP6) Preclinical research (WP7) Implementation and evaluation of prevention and therapeutics (WP11) Dissemination (WP14) Technological structures/resources Kinome analysis (WP4) DNA damage response (WP5) Technological resources (WP8) Bioinformatics (WP9) Biobanking (WP10) Patient data registries (WP11)