1. Working across sectors Building collaborative eco-systems Lars Sundstrom SARTRE

2.  Must be needs driven  Clinical Pull (Solves a problem or bottleneck)  Commercial Pull (Overcomes a barrier to commercialisation)  Basic Science Push (Application of new scientific knowledge)  Thus translation is all about collaborating and sharing knowledge across sectors. Translation to benefit Forward Basic science (Bench) Research Patients (Bedside) Products/Practise Reverse

3. University NHS Community Clinical practise Translational Research Translational Research Translational Medicine Translational Medicine Industry The Ecosystem Many groups need to interact to make it happen -Different cultures -Different drivers -Different incentives -Different languages

4. SARTRE - Building regional capacity Building critical mass 2000 registered research active basic and clinical scientists An active network and forum for discussions Developing major new strategic regional initiatives Supporting joint infrastructures Influencing policy at a local and national level Funding for translational projects MRC devolved funding scheme ~30 projects with ~200 scientists POC fund (10X gearing) Infrastructure funding

5. OI Case study (1) Starting with a solution Biosensor to detect Urinary Catheter blockage. Develop by biofilm experts in the dental school in Cardiff. Developed with a device company MBI Wales. Now in Clinical trials at the Bristol Urological Institute and in Cardiff and Vale Hospital. INCENTIVE = £50K per project Must have a translational end-point

6. OI Case Study (2) Starting with a Problem – Aimed at engaging physical sciences. – To Solve biomedical problems. – Expanded to include Bath and Exeter Universities. – Funded by EPSRC devolved portfolio. Challenge led & crowd sourced – I got a problem looking for a solution. – I got a solution looking for a problem. 50K per institution (can be combined) Must be more than 1 institution Must be multidisciplinary

7. Pathways to innovation Push: I have an idea does anyone want to help me develop it ? Pull: I have a problem does anyone have a solution ? Crowd sourcing maximises potential across any network but Works best in an ‘open Innovation’ context.

8. The Plan Develop a set of projects around clinical pull. Develop proof of concept Source follow on funding Site Miners Finding unmet needs Scoping projects Needs Sourcing Selecting the best Refining the ideas Building teams Project evaluation Developing proof of concept Follow on funding Proving the concept

10. Open Innovation paradigms and Crowd Science Generate ideas from all partners Collaborate to find solutions Build teams Innovate Generate value Needs some resource Some management Ability to develop joint projects Ability to work across sectors Collaboration

11. Challenges for OI in health Collaboration vs Competition – Individual vs Collective rewards – Cross institution working, open innovation platforms Working globally – Team based working, crowd sourcing, communication, project and alliance management Value systems – Protecting upside (IP) and minimising downside (FTO) Culture change – Finding the right incentives – Leadership and change advocacy

12. Increasing R&D costs is leading to more open and collaborative models with industry. Melese et al. Nature medicine 2009 15;5 502-507 Munos et al. Nature Reviews Drug Discovery 2010 9; 203-214 Cooperative models Open innovation models

13. Major problem- Development Gap is actually increasing Basic Research Discovery Research “Valley of Death” -Development Gap ©Obama Administration Commercial Development Shift of company Resources Shift of company Needs ‘Translational academic funding’ has increased by 30 % in the past 5 years in the UK. Also major EU Initiatives e.g. IMI Shift of academic Interest ?

14. Universities NHS R&D Partners Private sector partners: Local(SMEs) International (Pharma/Biotech/Medtech ) Public sector Partners: NISCHR/NIHR RCs /TSB/EU Value Creation License Product New Co Partnership Value Creation License Product New Co Partnership Pool of Ideas Projects Assessment Application Consolidation Proof of Principle Validation Energy Momentum Value Portfoilo approaches to Joint value creation  Synergy, Critical mass, Scale and Collaboration are byproducts  Active project management is essential with multiple actors  Flexible funding mechanisms are essential to catalyse collaborations

15. Building a new value chain through translational networks Big Industry Needs to provide pull Participate in a shared risk model Provide resources and expertise SME Anchor for local investment Pool of local entrepreneurial talent Shared risk with investors Govt Needs to provide incentives for collaboration Funding Commons and framework agreements Academia Collaborative research Milestone driven projects Knowledge Training IP must not be a barrier Sensible cost models SEWAHSP/TIME/SARTREMediwalesAHSCABPI