1. T H E B A S I C S Cancer: Reducing Your Risk 10 Grade Health

2. Agenda for Cancer Lecture Introduction (Etiology, Epidemiology, Oncologist) Introduction (Etiology, Epidemiology, Oncologist) Basic Understanding of Biology (cells) Basic Understanding of Biology (cells) Define Cancer (Autoimmune Disease) Define Cancer (Autoimmune Disease) Risk Factors (profile of our exposures) Risk Factors (profile of our exposures) Classifications of Cancer Classifications of Cancer Location of Cancer Location of Cancer Prevention, Detection and Treatment Prevention, Detection and Treatment

3. Introduction The last 50 years has seen a better understanding of the causes and treatments of cancer. Hence, the stigma, early detection and technology has improved the prognosis of cancer patients to an unprecedented level. The last 50 years has seen a better understanding of the causes and treatments of cancer. Hence, the stigma, early detection and technology has improved the prognosis of cancer patients to an unprecedented level.

4. Cancer Statistics 553,400 Americans died of cancer 2001 553,400 Americans died of cancer 2001 1.3 million new cases diagnosed 1.3 million new cases diagnosed 1 in 4 deaths from cancer 1 in 4 deaths from cancer Early detection/improvements in technology have improved prognosis for many Early detection/improvements in technology have improved prognosis for many What do you think are the contributing factors to the incidence of cancer in the U.S. today? What do you think are the contributing factors to the incidence of cancer in the U.S. today?

5. Healthy Cells Cells represent the smallest, functional unit of our existence which contains cytoplasm and a nucleus (i.e. metabolism, reproduction, day to day functions) Cells represent the smallest, functional unit of our existence which contains cytoplasm and a nucleus (i.e. metabolism, reproduction, day to day functions) Cells have a specialized function depending on their location in the body. Cells have a specialized function depending on their location in the body. Cells grow, replicate and repair body organs. Cells grow, replicate and repair body organs. The genetic material (DNA/RNA) and your immune system regulate this process. The genetic material (DNA/RNA) and your immune system regulate this process.

6. Different Types of Cells Blood cells Blood cells Muscle cells (smooth, striated, cardiac) Muscle cells (smooth, striated, cardiac) Nerve cells Nerve cells Bone cells Bone cells Cartilage cells Cartilage cells Liver (hepa) cells Liver (hepa) cells

7. Define Cancer Cancer is a term used to describe a large group of diseases that are characterized by a cellular malfunction. Healthy cells are programmed to “know what to do and when to do it”. Cancerous cells do not have this programming and therefore grow and replicate out of control. They also serve no physiological function. These cells are now termed a neoplasm. Cancer is a term used to describe a large group of diseases that are characterized by a cellular malfunction. Healthy cells are programmed to “know what to do and when to do it”. Cancerous cells do not have this programming and therefore grow and replicate out of control. They also serve no physiological function. These cells are now termed a neoplasm.

8. This neoplasmic mass often forms a clumping of cells known as a tumor.

9. Tumors Benign Tumors (noncancerous) Benign Tumors (noncancerous) Enclosed in a fibrous shell or capsule. Enclosed in a fibrous shell or capsule. Take up space Take up space Concerned if they interfere with surrounding tissues or vessels or impede the function of the body. Concerned if they interfere with surrounding tissues or vessels or impede the function of the body. Malignant Tumors (cancerous) Malignant Tumors (cancerous) Not usually contained – metastasis Not usually contained – metastasis Invade and emit clawlike protrusions that disrupt the RNA and DNA of normal cells (these cancerous cells act like a virus). Invade and emit clawlike protrusions that disrupt the RNA and DNA of normal cells (these cancerous cells act like a virus).

10. Risk Factors (multi-factorial) Exposure to Cancer-causing agents Exposure to Cancer-causing agents Cellular Mutations (what agents cause this? Environment & Lifestyle agents) Cellular Mutations (what agents cause this? Environment & Lifestyle agents) Genetics & Hormone exposure (i.e. breast cancer) Genetics & Hormone exposure (i.e. breast cancer) Occupation and Environment Factors Occupation and Environment Factors Social and Psychological Factors Social and Psychological Factors Chemicals in Food Chemicals in Food Viral (i.e. herpes, HPV, mononucleosis) create an opportunistic environment Viral (i.e. herpes, HPV, mononucleosis) create an opportunistic environment Medical Factors Medical Factors

11. Types of Cancer Classifications of Cancer Classifications of Cancer Carcinomas Carcinomas Sarcomas Sarcomas Lymphomas Lymphomas Leukemias Leukemias Lung Cancer Lung Cancer Killed 164,000 in 2000 Killed 164,000 in 2000 Prevention-researchers theorize: 90% of all lung cancers could be avoided by not smoking Prevention-researchers theorize: 90% of all lung cancers could be avoided by not smoking

12. Gas Exchange in Your Lungs

16. Lung and Bronchus Cancer (Invasive), 1975-2002 (CDC)

17. Lung and Bronchus Cancer for U.S. Males, 1992-2002

18. Lung and Bronchus Cancer for U.S. Females, 1992-2002

19. Ten Leading Causes of Death for Males, 2002 (CDC)

20. Ten Leading Causes of Death for Females, 2002 (CDC)

21. An Overview of Cancer Variations in Rates Variations in Rates Rates have large variations among populations Rates have large variations among populations 444.6 per 100,000 African Americans 444.6 per 100,000 African Americans 402.1 per 100,000 Whites 402.1 per 100,000 Whites 272.4 per 100,000 Hispanics 272.4 per 100,000 Hispanics 279.3 per 100,000 Asian Pacific Islanders 279.3 per 100,000 Asian Pacific Islanders 152.8 per 100,000 Native Americans 152.8 per 100,000 Native Americans

22. An Overview of Cancer What is Cancer? What is Cancer? Uncontrolled growth and spread of abnormal cells Uncontrolled growth and spread of abnormal cells Neoplasms Neoplasms Malignant tumors Malignant tumors Benign tumors Benign tumors

23. An Overview of Cancer Cellular Change/Mutation Theories Cellular Change/Mutation Theories Spontaneous errors Spontaneous errors External agents External agents Oncogenes Oncogenes Risks for Cancer-Lifestyle Risks for Cancer-Lifestyle Smoking among greatest Smoking among greatest Nutrition/exercise Nutrition/exercise

24. Factors Believed to Contribute to Global Causes of Cancer Figure 13.1

25. What Causes Cancer? Biological Factors Biological Factors Genetic predisposition Genetic predisposition Reproductive and hormonal risks Reproductive and hormonal risks

26. What Causes Cancer? Occupational and Environmental Factors Occupational and Environmental Factors Asbestos, nickel, chromate Asbestos, nickel, chromate Radioactive substances Radioactive substances Social and Psychological Factors Social and Psychological Factors Stress Stress Decrease negative emotions Decrease negative emotions

27. What Causes Cancer? Chemicals in Food Chemicals in Food Sodium nitrate Sodium nitrate Clostridium botulism Clostridium botulism Viral Factors Viral Factors Herpes-related virus and human papillomavirus Herpes-related virus and human papillomavirus Medical Factors Medical Factors Diethylstibestrol (DES) Diethylstibestrol (DES) Chemotherapy Chemotherapy

28. Table 13.1

29. Types of Cancer Breast Cancer Breast Cancer One in 8 women One in 8 women Risk increases with age Risk increases with age Risk factors supported by research Risk factors supported by research Prevention (self-exam and mammography) Prevention (self-exam and mammography) See figure 13.3 for self-examination procedure See figure 13.3 for self-examination procedure Treatment Treatment

30. Breast Self-Examination Figure 13.3

31. Types of Cancer Colon and Rectum Cancer Colon and Rectum Cancer 3 rd most common in men and women 3 rd most common in men and women 135,400 in 2001 diagnosed 135,400 in 2001 diagnosed Warning signals, e.g. blood in the stool, rectal bleeding Warning signals, e.g. blood in the stool, rectal bleeding Prostate Cancer Prostate Cancer Most common in males today Most common in males today 189,000 new cases will be diagnosed in 2002 189,000 new cases will be diagnosed in 2002 Estimated 30,200 men will die Estimated 30,200 men will die

32. Types of Cancer Skin Cancer: Sun Bathers Beware Skin Cancer: Sun Bathers Beware 1.3 million cases of skin cancer 1.3 million cases of skin cancer Treatable: basal or squamous Treatable: basal or squamous Virulent: malignant melanoma Virulent: malignant melanoma ABCD rule about melanoma ABCD rule about melanoma What are some ideas about the use of sunscreen? What are some ideas about the use of sunscreen?

33. Types of Cancer Testicular Cancer Testicular Cancer Ages 17-34 at greatest risk Ages 17-34 at greatest risk Cause is unknown Cause is unknown Undescended testicles present a great risk Undescended testicles present a great risk How and when should men examine their testicles? (see Figure 13.4) How and when should men examine their testicles? (see Figure 13.4)

34. Testicular Self-Examination Figure 13.4

35. Types of Cancer Ovarian Cancer Ovarian Cancer 4 th leading cause of death in young women 4 th leading cause of death in young women Enlargement of abdomen common sign Enlargement of abdomen common sign Prevention: annual pelvic exams Prevention: annual pelvic exams Endometrium (Uterine) Cancer Endometrium (Uterine) Cancer Pap test for early detection Pap test for early detection Risk: early onset of intercourse Risk: early onset of intercourse Warning: abnormal bleeding Warning: abnormal bleeding

36. Types of Cancer Cancer of the Pancreas Cancer of the Pancreas “Silent” disease “Silent” disease 29,700 cases in 2002 29,700 cases in 2002 Only 4% survive Only 4% survive Contributors: inflammation, diabetes, high-fat diet Contributors: inflammation, diabetes, high-fat diet

37. Types of Cancer Leukemia Leukemia Cancer of blood-forming tissues Cancer of blood-forming tissues Leads to the creation of immature white blood cells Leads to the creation of immature white blood cells Symptoms: fatigue / paleness / weight loss Symptoms: fatigue / paleness / weight loss Can be acute or chronic Can be acute or chronic

38. Facing Cancer Detecting Cancer Detecting Cancer Magnetic Resonance Imaging (MRI) Magnetic Resonance Imaging (MRI) Computerized Axial Tomography scanning (CAT scan) Computerized Axial Tomography scanning (CAT scan) Prostatic ultrasound (rectal probe) Prostatic ultrasound (rectal probe) Self-exam and check-ups Self-exam and check-ups

39. Table 13.3

40. Facing Cancer New Hope in Cancer Treatments New Hope in Cancer Treatments Surgery to remove tumor Surgery to remove tumor Chemotherapy Chemotherapy Researching genes and cell mutations Researching genes and cell mutations

41. Facing Cancer Talking with Your Doctor about Cancer Talking with Your Doctor about Cancer Ask questions about type, treatment, clinical trials Ask questions about type, treatment, clinical trials Ask about surgery Ask about surgery Ask why one treatment is preferred Ask why one treatment is preferred Get all your options Get all your options

42. Facing Cancer Life After Cancer Life After Cancer Laws reduce insurance discrimination Laws reduce insurance discrimination Less isolation Less isolation Assistance is available Assistance is available Support groups Support groups