1. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Memmler’s - The Human Body in Health and Disease 11th edition Chapter 15 Blood Vessels and Blood Circulation “I find that the harder I work, the more luck I seem to have.” Thomas Jefferson

2. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins The Vascular System Closed system Four heart chambers Blood vessels –Arteries from aorta –Arterioles –Capillaries –Venules –Veins – to the vena cava

3. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Checkpoint 15-1: What are the five types of blood vessels?

4. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Blood Circuits Two groups of blood vessels The pulmonary circuit –Pulmonary artery and its branches –Capillaries in lungs –Pulmonary veins The systemic circuit –Aorta –Systemic capillaries –Systemic veins

5. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Blood flow in a closed system of vessels. Oxygen content changes as blood flows through the capillaries. Zooming In Judging from color coding, which vessels pick up oxygen? Which vessels release oxygen?

6. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Checkpoint 15-2: What are the two blood circuits and what areas does each serve?

7. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Vessel Structure Three tunics (coats) of arteries and veins Inner (endothelium) Middle (smooth [involuntary] muscle) –Controlled by autonomic nervous system –Thinner in veins Outer (supporting connective tissue)

8. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Sections of small blood vessels. Drawings show the thick wall of an artery, the thin wall of a vein, and the single-layered wall of a capillary. A venous valve also is shown. The arrow indicates the direction of blood flow. Zooming In: Which vessels have valves that control blood flow?

9. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Checkpoint 15-3: What type of tissue makes up the middle layer of arteries and veins, and how is this tissue controlled? Checkpoint 15-4: How many cell layers make up the wall of a capillary?

10. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Question: True or False?: Pulmonary arteries carry blood that is low in oxygen.

11. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Answer: True: Pulmonary arteries carry blood that is low in oxygen.

12. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Systemic Arteries The aorta Largest artery that receives blood from left ventricle and has branches to all organs The Aortic parts –Ascending aorta –Aortic arch –Thoracic aorta –Abdominal aorta

13. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins The aorta and its branches. Zooming In: How many brachiocephalic arteries are there?

14. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Principal systemic arteries. Zooming In: How many brachiocephalic arteries are there?

15. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Branches of the Ascending Aorta and Aortic Arch Ascending aorta –Left and right coronary arteries Aortic arch –Brachiocephalic artery Right subclavian artery Right common carotid artery –Left common carotid artery –Left subclavian artery

16. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Branches of the Thoracic Aorta Also known as the descending aorta Branches to chest wall, esophagus, and bronchi Intercostal arteries

17. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Branches of the Abdominal Aorta Celiac trunk –Left gastric artery –Splenic artery –Hepatic artery Superior mesenteric artery Inferior mesenteric artery Paired lateral branches –Phrenic arteries –Suprarenal arteries –Renal arteries –Ovarian and testicular arteries –Lumbar arteries

18. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Checkpoint 15-5: What are the subdivisions of the aorta, the largest artery?

19. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Question: Which branch of the aorta divides further into 3 arteries, one of which serves the liver? a. superior mesenteric artery b. celiac trunk c. aortic arch

20. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Answer: b. celiac trunk

21. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins The Iliac Arteries and Their Subdivisions Internal iliac arteries External iliac arteries –Femoral artery Popliteal artery Tibial arteries Dorsalis pedis

22. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Arteries That Branch to the Arm and Head External carotid artery Internal carotid artery Subclavian artery –Vertebral artery –Axillary artery Brachial artery Radial artery Ulnar artery

23. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Checkpoint 15-6: What arteries are formed by the final division of the abdominal aorta?

24. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Anastomoses Communication between two vessels Circle of Willis Superficial palmar arch Mesenteric arches Arterial arches

25. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Arteries that supply the brain. The bracket at right groups the arteries that make up the circle of Willis. A – all communicating, B- basilar, and C – cerebral artery

26. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Checkpoint 15-8: What is an anastomosis?

27. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Systemic Veins Superficial veins –Cephalic, basilic, median cubital veins –Saphenous veins Deep veins –Femoral and iliac vessels –Brachial, axillary, subclavian vessels –Jugular veins –Brachiocephalic vein

28. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins The Venae Cavae and Their Tributaries Superior vena cava –Head, neck, upper extremities Inferior vena cava –Right, left veins from paired parts, organs –Unpaired veins from spleen, digestive tract

29. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Principal systemic veins. Zooming In: How many brachiocephalic veins are there?

30. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Checkpoint 15-9: Veins are described as superficial or deep. What does superficial mean? Checkpoint 15-10: What two large veins drain the systemic blood vessels and empty into the right atrium?

31. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Question: What is the name of the unpaired vein that drains the veins of the chest wall? a. azygous vein b. cephalic vein c. subclavian vein

32. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Answer: a. azygous vein

33. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Venous Sinuses Coronary sinus Cranial venous sinuses –Cavernous sinuses Petrosal sinuses –Superior sagittal sinus Confluence of sinuses –Transverse sinuses (lateral sinuses)

34. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Cranial venous sinuses. The inset shows the paired transverse sinuses, which carry blood from the brain to the jugular veins.

35. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Checkpoint 15-11: What is a venous sinus?

36. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins The Hepatic Portal System Carries blood from abdominal organs to liver Superior mesenteric vein Splenic vein Gastric, pancreatic, inferior mesenteric veins Sinusoids

37. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Hepatic portal system. Veins from the abdominal organs carry blood to the hepatic portal vein leading to the liver. Arrows show the direction of blood flow. Zooming In: What vessel do the hepatic veins drain into?

38. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Checkpoint 15-12: The hepatic portal system takes blood from the abdominal organs to what organ?

39. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Circulation Physiology Blood exchanges oxygen, carbon dioxide, other substances generated by cells Tissue fluid (interstitial fluid) is exchange medium

40. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Connection between small blood vessels through capillaries. The blood delivers oxygen (O2) to the tissues and picks up carbon dioxide (CO2) for transport to the lungs. Note the lymphatic capillaries, which aid in tissue drainage.

41. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Capillary Exchange How substances move between cells and capillary blood Diffusion –Main process Blood pressure (hydrostatic pressure) –Moves (pushes) material into tissue fluid Osmotic pressure (osmotic colloidal pressure) –Moves (pulls) material into capillaries

42. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Checkpoint 15-13: As materials diffuse back and forth between the blood and tissue fluid across the capillary wall, what force helps to push materials out of the capillary? What force helps to draw materials into the capillary?

43. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins The Dynamics of Blood Flow Vasomotor center in medulla regulates vasomotor activities Vasodilation Vasoconstriction Precapillary sphincter

44. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Checkpoint 15-14: Name the two types of vasomotor changes. Checkpoint 15-15: Where are vasomotor activities regulated?

45. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Return of Blood to the Heart Mechanisms that promote blood’s return to heart –Contraction of skeletal muscles –Valves –Breathing

46. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Role of skeletal muscles and valves in blood return. (A) Contracting skeletal muscle compresses the vein and drives blood forward, opening the proximal valve, while the distal valve closes to prevent backflow of blood. (B) When the muscle relaxes again, the distal valve opens, and the proximal valve closes until blood moving in the vein forces it open again.

47. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Question: What is the name for the collection of vessels that carries blood from the abdominal organs to the liver? a. venous sinuses b. internal and external iliac arteries c. hepatic portal system

48. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Answer: c. hepatic portal system

49. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins The Pulse Ventricular contraction Wave of increased pressure Begins at heart and travels to arteries Influenced by various factors –Body size –Gender –Age –Muscular activity –Emotion –Body temperature –Thyroid secretion

50. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Checkpoint 15-16: What is the definition of pulse?

51. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Blood Pressure Force exerted by blood against vessel walls Determined by heart’s output and resistance to blood flow

52. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Cardiac Output Volume of blood pumped out of each ventricle in one minute Heart rate –Beats per minute Stroke volume –Controlled by force of contractions

53. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Resistance to Blood Flow Peripheral resistance is affected by Vasomotor changes Baroreceptors in large arteries Elasticity of blood vessels Viscosity Total blood volume

54. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Blood Pressure Measurement Pressure is measured in the brachial arm artery using a sphygmomanometer Systolic pressure –Occurs during heart contraction –Normal systolic: 120 mmHg Diastolic pressure –Occurs during heart relaxation –Normal diastolic: 80 mmHg

55. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Checkpoint 15-17: What is the definition of blood pressure? Checkpoint 15-18: What two components of blood pressure are measured?

56. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Question: What is the name of the device used to measure blood pressure? a. hematocrit b. hemocytometer c. sphygmomanometer

57. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Answer: c. sphygmomanometer

58. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Abnormal Blood Pressure Hypotension –Lower than normal blood pressure Hypertension –High blood pressure Essential hypertension –No apparent medical cause

59. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Treatment of Hypertension Stage 1 –140/90 mm Hg –Diet, exercise, weight loss Stage 2 –160/100 mm Hg –Drugs added to treatment

60. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Checkpoint 15-19: What is meant by hypertension and hypotension?

61. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Arterial Degeneration and Other Blood Vessel Disorders Arteriosclerosis –Atherosclerosis Clot formation Leg cramps, pain, lameness Cerebral artery sclerosis Hypertension Coronary artery arteriosclerosis Renal artery damage Ischemia, gangrene

62. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Treatment for Arterial Degeneration Balloon catheterization Bypass grafts Stents Endarterectomy

63. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Aneurysm Bulging sac in blood vessel wall Swelling deranges other structures Can burst, causing death Surgery can replace damaged segment

64. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Hemorrhage Profuse escape of blood from vessels Internal or external Can be life-threatening –Apply pressure to wound –Elevate extremity above heart –Apply pressure to pressure point

65. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Shock Inadequate blood flow to tissues Classified by type –Cardiogenic –Neurogenic –Septic –Hypovolemic –Anaphylactic Classified by severity (cause unknown) –Mild –Severe

66. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Checkpoint 15-20: With regard to the circulation, what is meant by shock?

67. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Thrombosis Formation of blood clot in a vessel Deep venous thrombosis (DVT) Embolus Pulmonary embolism Phlebitis Thrombophlebitis

68. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Varicose Veins Superficial veins that are swollen, distorted, and ineffective Saphenous veins of lower extremities Rectal veins (hemorrhoids)

69. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Question: What is the term for a portion of a blood clot that breaks loose and floats in the blood? a. phlebitis b. thrombus c. embolus

70. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Answer: c. embolus

71. Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins Questions?