2. 2 The Application of medical or cosmetic products on the skin always is affected by the Top Layer: The Stratum Corneum It is a barrier against most of the substances we handle.

3. Electroporation can channel-in positive, negative, and neutral molecules by creating new channels through the cells and the cell- membrane. It`s effect can be compared to a syringe.

4. Cellulite is known by women as an aesthetic problem, and is, in reality, a disease of subcutaneous connective tissue Cellulite Cellulite accumulates regardless of weight or physical fitness, usually appearing on legs, buttocks, hips and stomach.

6. Thus, cellulite may be due to a variety of factors: hormonally mediated fat deposition, fat lobule compression of capillary vasculature, decreased venous return, formation of clumped fat lobules, and deposition of protein substances around clumped fat lobules.

7. To efficiently cure cellulite, it is necessary, therefore to act locally and to eliminate systemic causes. A correct approach to cellulites should consider every pathogenetic aspect. One important aspect is the avoidance of overweight from childhood A moderate physical activity of any kind is important. Many substances could be effective in the reduction of cellulite: spreading enzymes like hyaluronidase, thiomucase or lipolytic factors like L-tiroxina and teofillina

8. Cellulite Protocol Materials and Method Acthyderm Pulse – Multifunctional Electroporation Generator Bio-Cell

9. Operatively, we will transpose a virtual grid pattern, on the area, using the stylus as a pen-like device.

10. The roll-on Electrode diffuses, through the opened electropores, the active principal ingredients contained in the bottle. The roller electrode is positively charged. Therefore, positively charged ions are pressed into the skin by electrorepulsion.

11. Summary Normally, topical treatments have product penetration of about 10 %. Electroporation with Acthyderm gives penetration rates of over 90 % ! Transdermal Electroporation may be used in all area with cellulite, does not leave signs, is not painful and, since it is a local therapy, it does not have side effect and may be applied safely. 14

12. CELLULITE REDUCTION 14

13. After 5 applications /3WK

14. After 4 applications 2WK

15. After 10 applications /5WK

16. BREAST TONING 14

17. After 1 application

18. FACE & NECK REJUVENATION 14

19. Operatively, we will transpose a virtual grid pattern, on a facial area, using the stylus as a pen-like device.

21. The roll-on Electrode diffuses, through the opened electropores, the active principal ingredients contained in the bottle. The roller electrode is positively charged. Therefore, positively charged ions are pressed into the skin by electrorepulsion.

22. As a further effect, the generated High Intensity short pulses will strengthen and tighten the tissue, enhancing the effect of facial lifting 13

23. Summary Normally, skin care treatments have product penetration of about 10 %. Electroporation with Acthyderm gives penetration rates of over 90 % ! Hence the application of medical or cosmetic substances by Acthyderm treatment is comparable to application done by a syringe. 14 But without pain, with less danger of infection, and without injuring the skin anyway.

24. Wrinkles  after  before after 1 treatments

25. After 1 application Foto non ritoccate

27. After 9 applications /2WK

28. After 3 applications / 1WK

29. Solar lentigines  after  before after 13 treatments

30. Hyperpigmentation and rejuvenation  after  before after 13 treatments

31. Neck rejuvenation  after  before after 4 treatments

32. The Acthyderm defines the best in aesthetic technology today.  Acthyderm opens a new and fascinating territory of limitless possibilities. of limitless possibilities.  Effectiveness comparable to injection-type mesotherapy.  Immediate results, ultimate comfort and unparalleled gratitude of from your customers.  Technology that will not be easily replaced.

33. Thank-you for the attention