1. Esophageal Strictures William Stanford – Leader & BSAC Daniel Frost – BWIG Thomas Fleming – Communicator Client: Dr. Mark Reichelderfer, MD Advisor: Professor John Webster

2. Presentation Outline Problem Statement Background Information Current Methods Design Constraints Possible Designs Future Work

3. Background Information Esophageal Stricture Stomach acid reflux into esophagus forms stricture Also from cancer, lung problems, and genetics Causes heartburn Treatment Surgery and dilation Surgery is complicated and risky Dilation is more safe Inflatable balloon inside the esophagus

4. Background Information Stricture Size and Compliance Compliance = Volume/Pressure Little work has been done involving compliance Compliance gives information about scar tissue Can lead to better treatment options Potential correlation between stricture types

5. Problem Statement Device should: Measure pressure in balloon Measure change in volume of syringe Graph volume/pressure curve in real time Be aesthetically pleasing for hospital setting Eventually be commercially available

6. Design Constraints Work with current dilation procedure Provide real time data Provide warning of esophageal perforation Software that runs on hospital computers Compliance accurate to three significant figures Compact enough for hospital setting Safety

7. Current Prototype Syringe is filled with saline Pressure measured with pressure transducer Volume measured with linear potentiometer Outputs are connected to an amplifier circuit Circuit connects to computer

8. Design 1: LabView Advantages: Real time graphing Reads two inputs Automatically converts units Simple inputs Image oriented programming Disadvantages: Complicated Time consuming to learn Relatively expensive

9. Design 2: BioBench Advantages: No programming required Has a playback mode Multiple inputs Less expensive Disadvantages: No real time graphing No automatic unit conversion Data has to be exported in Microsoft Excel

10. Design 3: Pasco Advantages: Real time graphing Data can be entered into equations Easy to use Two inputs Least expensive Disadvantages: No support for saline pressure sensor

11. Design Matrix Weight (out of 100) LabViewBioBenchPasco Graphing Capability 70 1060 Ease of Use5234 Inputs10990 Unit Conversion 10816 Cost5125 Total100902575

12. Future Work Write software program for graphing Develop amplification circuit Testing Aesthetic finalization Gain IRB approval Human testing

13. References http://sine.ni.com/nips/cds/view/p/lang/en/nid/1454 http://en.wikipedia.org/wiki/Image:Labview-logo.png http://www.pasco.com Hale, A. et. al. (2002). Barostat to Measure Esophageal Strictures. Kirking, H. et. al. (2002). Barostat to Measure Esophageal Strictures. Seashore, K. et. al. (2006). Device for Dilating Esophageal Strictures.