1. Diseases/Disorders of the Integumentary system Honors Anatomy and Physiology Ms. Susan Chabot

2. Categories of Disorders Infectious: caused by a pathogen that infects the skin or enters through an opening. Allergic/Environmental Trauma/Burns Cancer Congenital Genetic

3. Athletes Foot Tinea pedis: Athlete’s foot resulting from a fungal infection. Red, itchy, peeling skin. Treatment involves an antifungal cream or pill that will destroy the pathogen. Other similar cutaneous fungal infections include: –Ringworm –Sun spots

4. Cutaneous Fungal Infections

5. Boils and carbuncles Inflammation of hair follicles and sebaceous glands. Typically caused by bacterial infection; Staphylococcus aureus. Easily treated with an antibiotic that will destroy the bacteria if used properly.

6. Staph Infections and MRSA –M = Methicillin, a potent antibiotic –R = Resistant –S = Staphylococcus –A = Aureus MRSA = staph infection that is no longer cured with traditional antibiotics. 1950’s: hospital-acquired or NOSOCOMIAL infection. –1.2 million infections/19,000 deaths in 2011. Now becoming community-acquired. –19000 cMRSA deaths in 2011.

7. What does MRSA look like?

8. Impetigo Bacterial infection Pink, water-filled raised lesions. Usually found around the mouth and nose. HIGHLY contagious. Common in young children. Easily treated with antibiotics.

9. Cold sores Caused by herpes simplex (viral) infection. Small, fluid-filled blisters that itch and sting. Virus follows a cycle – Outbreaks result from environmental or emotional stresses. OTC medications can shorten infection time or reduce the size of the lesion. No cure.

10. Checkpoint Questions What 3 types of pathogens can cause infections in the skin? How do we treat a herpes simplex infection? What does MRSA stand for? What is the treatment for typical bacterial infections?

11. Checkpoint Questions What 3 types of pathogens can cause infections in the skin? Fungus, Bacteria, Virus How do we treat a herpes simplex infection? OTC medicines only. No cure What does MRSA stand for? Methicillin Resistant Staphylococcus Aureus What is the treatment for typical bacterial infections? Antibiotics

12. Categories of Disorders Infectious Allergic/Environmental: exposure to agents that lead to irritation/inflammation. Trauma/Burns Cancer Congenital Genetic

13. Contact dermatitis Itching, redness, swelling of skin. Progresses to blisters. Caused by exposure to chemicals. Provokes an allergic response. Treated with steroids to reduce inflammation. Poison Ivy Chemical burn

14. Psoriasis Chronic condition; characterized by red lesions covered with dry, silvery scales. Cause is unknown, but may be hereditary. Attacks often brought on by emotional upset, hormonal changes, and trauma.

15. Categories of Disorders Infectious Allergic/Environmental Trauma/Burns: damage caused by injury; including heat, cold, blunt force Cancer Congenital Genetic

16. Burns A burn is tissue damage and cell death caused by intense heat or cold, electricity, UV radiation, or chemicals. Two life-threatening problems 1. Loss of fluids resulting in dehydration and electrolyte imbalance. 2. Threat of infection due to loss of intact barrier.

17. Rule of Nines Used to determine the volume of fluid needed to replace fluid lost from a severe burn. Method divides the body into 11 areas, each accounting for 9% of the total body surface. 1% is the genital region.

18. First-degree burn Only the epidermis is damaged. Area becomes red and swollen. Temporary discomfort. Generally not serious and heals in two to three days. Example: sunburn

19. Second-degree burn Injury to the epidermis and the upper region of the dermis. Skin is red, painful, and blistered. Regeneration will occur. Usually no permanent scarring.

20. Third-degree burn AKA Full Thickness Burn; destroys the entire thickness of the skin. Burned area appears blanched (gray-white) or blackened. Nerve endings are destroyed. Requires skin grafts.

21. Categories of Disorders Infectious Allergic/Environmental Trauma/Burns Cancer: abnormal mitosis leading to malignancy. Congenital Genetic

22. Skin cancer The most commonly diagnosed cancer Many factors can affect a person ’ s predisposition to getting skin cancer. Genetics Exposure to UV radiation Frequent skin irritation Physical trauma

23. Basal cell carcinoma Least malignant/ most common Involves cells of st. basale. No longer forms keratin; invades dermis and hypodermis. Shiny, dome shaped nodule that eventually develops a central ulcer with raised edge.

24. Squamous cell carcinoma Arises from cells in st. spinosum Scaly red papule that forms a shallow ulcer with a firm raised border. Grows rapidly and spreads quickly to lymph nodes. Good chance for cure if caught early.

25. Malignant melanoma Cancer of melanocytes. 5% of skin cancers. Occurs wherever there is pigment. Randomly located, but can occur from a pigmented mole. Spreads quickly to lymph nodes and blood vessels.

26. ABCD Rule A: Asymmetry. B: Border irregularity. C: Color. The pigmented spot contains different colors. D: Diameter. The spot is larger than 6 mm in diameter.

27. Categories of Disorders Infectious Allergic/Environmental Trauma/Burns Cancer Congenital: malformation of development occurring during gestation (pregnancy) Genetic

28. Hemangioma Benign swelling of the lining of blood vessels. Dense capillary network that does not dissolve as fetal development progresses. Many dissolve on own without intervention by age 10. Some can be severely disfiguring. CAUTION!

30. Categories of Disorders Infectious Allergic/Environmental Trauma/Burns Cancer Congenital Genetic: mutation of a specific gene sequence that leads to a malformation of a protein needed for normal structure or function.

31. Ichthyosis Malformation of proteins needed for normal skin development. Rough, scaly, “fish- like” skin. Most dangerous is Harlequin type.

32. Epidermolysis bullosa Malformation of collagen and other connective proteins that bind/hold the skin together. Results in blistering as the epidermis pulls away from the dermis.