1. CAMPBELL BIOLOGY IN FOCUS © 2014 Pearson Education, Inc. Urry Cain Wasserman Minorsky Jackson Reece 13 The Molecular Basis of Inheritance Questions prepared by Brad Stith, University of Colorado Denver Louise Paquin, McDaniel College Christopher Gregg, Louisiana State University

2. © 2014 Pearson Education, Inc. Who conducted the X-ray diffraction studies that were key to the discovery of the structure of DNA? A.Griffith B.Franklin C.Meselson and Stahl D.Chargaff E.McClintock

3. © 2014 Pearson Education, Inc. Who conducted the X-ray diffraction studies that were key to the discovery of the structure of DNA? A.Griffith B.Franklin C.Meselson and Stahl D.Chargaff E.McClintock

4. © 2014 Pearson Education, Inc. How do the leading and the lagging strands differ? A.The leading strand is synthesized in the same direction as the movement of the replication fork, and the lagging strand is synthesized in the opposite direction. B.The leading strand is synthesized at twice the rate of the lagging strand. C.The lagging strand is synthesized continuously, whereas the leading strand is synthesized in short fragments that are ultimately stitched together. D.The leading strand is synthesized by adding nucleotides to the 3' end of the growing strand, and the lagging strand is synthesized by adding nucleotides to the 5' end.

5. © 2014 Pearson Education, Inc. How do the leading and the lagging strands differ? A.The leading strand is synthesized in the same direction as the movement of the replication fork, and the lagging strand is synthesized in the opposite direction. B.The leading strand is synthesized at twice the rate of the lagging strand. C.The lagging strand is synthesized continuously, whereas the leading strand is synthesized in short fragments that are ultimately stitched together. D.The leading strand is synthesized by adding nucleotides to the 3' end of the growing strand, and the lagging strand is synthesized by adding nucleotides to the 5' end.

6. © 2014 Pearson Education, Inc. What kind of evidence about the structure of DNA came from each of the following branches of science? A.physics B.chemistry C.biology

7. © 2014 Pearson Education, Inc. If the result of the Hershey and Chase experiment had been that radioactive sulfur ( 35 S) was found inside the cells instead of radioactive phosphorous ( 32 P), what could have been concluded?

8. © 2014 Pearson Education, Inc. Define and diagram “semiconservative” as it applies to DNA replication.

9. © 2014 Pearson Education, Inc. Telomeres, or the ends of linear chromosomes, have special structure and function, even though they are noncoding. Describe their structure and function.

10. © 2014 Pearson Education, Inc. What enzyme does a gamete-producing cell include that compensates for replication-associated shortening? A.DNA polymerase II B.ligase C.telomerase D.DNA nuclease E.proofreading enzyme

11. © 2014 Pearson Education, Inc. What enzyme does a gamete-producing cell include that compensates for replication-associated shortening? A.DNA polymerase II B.ligase C.telomerase D.DNA nuclease E.proofreading enzyme

12. © 2014 Pearson Education, Inc. Which of the following is true of heterochromatin but not of euchromatin? A.It is accessible to enzymes needed for gene expression. B.It becomes less tightly compacted after cell division. C.It includes DNA primarily found in expressed genes. D.It appears more pale when observed microscopically. E.It remains tightly coiled at the G 1 phase.

13. © 2014 Pearson Education, Inc. Which of the following is true of heterochromatin but not of euchromatin? A.It is accessible to enzymes needed for gene expression. B.It becomes less tightly compacted after cell division. C.It includes DNA primarily found in expressed genes. D.It appears more pale when observed microscopically. E.It remains tightly coiled at the G 1 phase.

14. © 2014 Pearson Education, Inc. Which of the following is an example of “recombinant DNA”? A.combining alternate alleles of a gene in a single cell B.manipulating a meiotic crossing-over event C.cloning genes from homologous pairs of chromosomes D.introducing a human gene into a bacterial plasmid E.alternate alleles assorting independently

15. © 2014 Pearson Education, Inc. Which of the following is an example of “recombinant DNA”? A.combining alternate alleles of a gene in a single cell B.manipulating a meiotic crossing-over event C.cloning genes from homologous pairs of chromosomes D.introducing a human gene into a bacterial plasmid E.alternate alleles assorting independently

16. © 2014 Pearson Education, Inc. This segment of DNA is cut at restriction sites 1 and 2, which creates restriction fragments A, B, and C. Which of the following electrophoretic gels represents the separation of these fragments? A. B. C. D.

17. © 2014 Pearson Education, Inc. This segment of DNA is cut at restriction sites 1 and 2, which creates restriction fragments A, B, and C. Which of the following electrophoretic gels represents the separation of these fragments? A. B. C. D.