1. Cancers of the Reproductive System Review Session November 19, 2012

2. Ashkan Afshin, MD, MPH ScD Candidate, Department of Epidemiology ScD Candidate, Department of Global Health & Population Harvard School of Public Health Room 913 Kresge Building, Room 913 677 Huntington Avenue Boston, Massachusetts 02115 Phone: (949) 235-6137 Email: aafshin@hsph.harvard.eduaafshin@hsph.harvard.edu

3. Review Sessions Format: Q & A (20 min) Discussing the questions received by email (10 min)

4. Questions Please send your questions or suggestions to:  Text Message: (949) 235-6137  Email: aafshin@hsph.harvard.eduaafshin@hsph.harvard.edu

5. Midterm Exam

8. Stages of Tumor Development Weinberg RA. How cancer arises. Sci Am. 1996 Sep;275(3):62-70. A B C E D

9. Stages of Tumor Development Weinberg RA. How cancer arises. Sci Am. 1996 Sep;275(3):62-70.

10. Genetic Abnormalities in Cancer Cells

11. A.Oncogenes HER2 → Breast Cancer B.Tumor Suppressor: BRCA→ Breast Cancer

12. New cases of cancer in the US American Cancer Society. Cancer Facts & Figures 2012. Atlanta: American Cancer Society.

13. New cases of cancer in the US American Cancer Society. Cancer Facts & Figures 2012. Atlanta: American Cancer Society.

14. New cases of cancer in the US American Cancer Society. Cancer Facts & Figures 2012. Atlanta: American Cancer Society.

15. True or False? Testicular cancer is the most common form of cancer in men 16-34 Positive family history of the testicular cancer increases the risk of the cancer Testicular cancers is more common in African American males. Carcinoma in situ can sometimes progress to invasive cancer Obese men show highest risk of testicular cancer

16. True or False? Testicular cancer is the most common form of cancer in men 16-34 Positive family history of the testicular cancer increases the risk of the cancer Testicular cancers is more common in African American males. Carcinoma in situ can sometimes progress to invasive cancer Obese men show highest risk of testicular cancer

17. Race & Prostate Cancer World J Urol (2012) 30:195–200 Mortality Incidence

18. Race & Prostate Cancer World J Urol (2012) 30:195–200 Mortality Incidence

19. Diet & Prostate Cancer Risk Dietary FactorDirection of Effect Calcium Processed Meat Intake Fish Intake Vitamin D Tomatoes Giovannucci et al. Int. J. Cancer: 121, 1571–1578 (2007) Wilson et al. J Natl Cancer Inst. 2011;103(11):876-84. Chan et al. J Clin Oncol 23:8152-8160

20. Diet & Prostate Cancer Risk Dietary FactorDirection of Effect Calcium  (fatal & adv disease) Processed Meat Intake  Fish intake  (fatal disease) Vitamin D  Tomatoes  Giovannucci et al. Int. J. Cancer: 121, 1571–1578 (2007) Wilson et al. J Natl Cancer Inst. 2011;103(11):876-84. Chan et al. J Clin Oncol 23:8152-8160

21. Other Risk Factors for Prostate Cancer Risk FactorDirection of effect Height BMI

22. Other Risk Factors for Prostate Cancer Risk FactorDirection of Effect Height  (fatal disease) BMI  (adv/fatal disease)

23. Breast Cancer Risk Factors True or False? –Nulliparity –Early menarche –Early menopause –Postmenopausal hormone use –Older forms of birth control pills –Premenopausal obesity –Alcohol use

24. Breast Cancer Risk Factors True or False?  Nulliparity  Early menarche Early menopause  Postmenopausal hormone use  Older forms of birth control pills Premenopausal obesity  Alcohol use

25. Race/Ethnicity and Breast Cancer American Cancer Society. Breast Cancer Facts & Figures 2011-2012. Atlanta: American Cancer Society.

26. Race/Ethnicity and Breast Cancer

27. American Cancer Society. Global Cancer Facts & Figures 2nd Edition. Atlanta: American Cancer Society; 2011.

28. Endometrial Cancer Risk Factors True or False: –Nulliparity, –Early menarche –Late Menopause –Obesity –Prior breast cancer treatment with tamoxifen –Polycystic ovarian syndrome (PCOS)

29. Endometrial Cancer Risk Factors True or False:  Nulliparity,  Early menarche  Late Menopause  Obesity  Prior breast cancer treatment with tamoxifen  Polycystic ovarian syndrome (PCOS)

30. Obesity Obesity is not a risk factor for: –Breast Cancer –Ovarian Cancer –Testicular Cancer –Prostate Cancer

31. Obesity Obesity is not a risk factor for: –Breast Cancer –Ovarian Cancer –Testicular Cancer –Prostate Cancer