1. Issues in Inorganic Synthesis

2. Ligand synthesis in NaOH pH ~11 MeOH 20 h or so Solvent : ethylene glycol

3. Porphyrin substituents on heme in hemoglobin Metallation of porphyrin How do you know when the reaction is done? Anything change at Fe?

4. Molybdenum Reactions. List them and conditions  MoOCl 2 detc 2  Mo 2 O 3 detc 4  MoOS 2 detc 2  MoOdetc 2

5. Fe and Ru Reactions. List them and conditions  FeCl(porphyrin)  Ru(bpy) 2 (L-pterin)

6. Mechanism:

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8. What’s the difference between pictures A and B? A B from X-ray crystallography from Chem 3D; “guessed” structure

9. X-ray Crystallography: the closest we can get to photographing our molecules! single crystal (not a powder or many tiny crystals) periodic array of atoms symmetrically oriented produces accurate (almost) bond distances and bond angles The method: see U.Penn X-ray FacilityU.Penn X-ray Facility see on-line X-ray Courseon-line X-ray Course see illustration of Space Group Symmetryillustration of Space Group Symmetry one of my old structures (on Cu)old structures (on Cu)

10. A single crystal structure of a Mo molecule from my lab:

12. Who wants to go see it done?