1. + Genital Herpes By: Katie Redinger

2. + History Known for at least 2,000 years Emperor Tiberious banned kissing due to cold sores

3. + History “Vocational disease of women” Not found to be a virus until the 1940s

4. + History Disease became stigmatized during the 1970s Merely a cold sore in an odd place

5. + What is Genital Herpes? STD caused by Herpes Simplex Virus – Type 1 or 2 Most caused by HSV-2

6. + What is Genital Herpes? Herpesviridae family Similar to Hand, Foot and Mouth disease

7. + What is Genital Herpes? Lays dormant in ganglion Never goes away Flare ups occur in location of exposure

8. + What is Genital Herpes? Infection at one site prevents infections starting in another site. (Genital, Oral, Ocular, Whitlow) Creates antibodies

9. + Structure Double stranded DNA virus Uses RNA polymerase II to create viral DNA

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11. + Symptoms Break outs of blisters, chancres, and tender ulcers More serious cases affect the eye and central nervous system

12. + Symptoms First outbreak usually occurs within 2 weeks of exposure May also include flu-like symptoms Frequency decreases overtime (4-5 within a year)

13. + Complications Bell’s Palsy, facial paralysis, may be caused by HSV-1 Proposed Alzheimer's.

14. + Transmission Contact with ruptured sores Skin to skin contact Sexual contact

15. + Transmission Can occur between outbreaks Skin may contain virus without sores (small rash)

16. + Transmission HSV-2 Genital to Genital HSV-1 Oral to Oral, Hand to Oral, Oral to Genital

17. + Demographics 16.2 % (1/6) Americans ages 14-49 have HSV-2 More common in women Transmission is more common Male  Female (8-10%)

18. + Demographics Worldwide rate of infection 60-90%

19. + Prevention Use of condoms Abstinence

20. + Living with Herpes Topical creams Vaccines are in clinical trial Antivirals

21. + Sources