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Revolutionising DNA analysis in major crime investigations The Investigator Conferences Green Park Conference Centre May, 2014 Aylesbury, Buckinghamshire.

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Presentation on theme: "Revolutionising DNA analysis in major crime investigations The Investigator Conferences Green Park Conference Centre May, 2014 Aylesbury, Buckinghamshire."— Presentation transcript:

1 Revolutionising DNA analysis in major crime investigations The Investigator Conferences Green Park Conference Centre May, 2014 Aylesbury, Buckinghamshire Mark W Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PA Cybergenetics © 2003-2014

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3 Commonwealth v. Lyons homicide: DNA mixture evidence Victim's blood spatter pulsating spray from severed carotid artery 75% victim 25% other

4 DNA molecule

5 Copy DNA Copy intact DNA

6 Normal DNA signal

7 Degraded DNA Can’t copy broken DNA

8 Longer molecules copy less With degradation, a longer DNA molecule has a greater chance of having a break

9 DNA decay curve DNA size Observed DNA With degradation, a longer DNA molecule makes fewer DNA copies

10 Degraded DNA signal

11 Degraded DNA Mixture Degraded other DNA Victim DNA

12 Match statistic comparison Human Computer 42,000 9,500,000,000,000

13 Computer Interpretation of Quantitative DNA Evidence Commonwealth v. Lyons June, 2011 Reading, PA Mark W Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PA Cybergenetics © 2003-2011

14 DNA evidence interpretation Evidence item Evidence data LabInfer 10 11 12 Evidence genotype Known genotype 10, 12 @ 50% 11, 12 @ 30% 12, 12 @ 20% 10, 12 Compare

15 Computers can use all the data Quantitative peak heights at locus D8S1179 victim other

16 People may use less of the data Over threshold, peaks become allele events. Under threshold, alleles vanish. All-or-none allele peaks; ignore victim genotype Threshold

17 How the computer thinks Consider every possible genotype solution victim other Explain the peak pattern Better explanation gives a higher probability

18 Evidence genotypes victimother

19 DNA match information Probability(evidence match) Probability(coincidental match) How much more does the suspect match the evidence than a random person? 6x

20 Is the suspect in the evidence? A match between the suspect and the evidence is 9.46 trillion times more probable than coincidence. Yes, with a reasonable degree of scientific certainty, evidence item Q9 contains DNA from the genotype of suspect item K2.

21 Is the victim in the evidence? A match between the victim and the evidence is 1.27 quintillion times more probable than coincidence. Yes, with a reasonable degree of scientific certainty, evidence item Q9 contains DNA from the genotype of victim item K1.

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23 Getting Started http://www.cybgen.com/support

24 Questions?

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