1. Carsten R. Smidt, Ph.D., FACN Vice President, Global R&D, Pharmanex
Thank you, Werner. This technology would not be available today if it weren’t for the brilliant minds and willpower of a robust team of independent and in-house scientists. We are also very proud to have the “father of antioxidants” associated with our company as a member of the Pharmanex Scientific Advisory Board. He is actually here in the front row of the audience today with us. Ladies and Gentleman, Dr. Lester Packer.
(Packer stands and waves, audience claps)
Pharmanex is unique in the industry. We not only value the science upon which our products are based, we can measure the science. LifePak and the Pharmanex BioPhotonic Scanner provide an opportunity for Pharmanex to provide a “measurable difference.”
Carsten R. Smidt, Ph.D., FACN
Vice President, Global R&D, Pharmanex

2. What is LifePak?
A comprehensive nutritional wellness program delivering the optimum amounts of all essential and generally beneficial nutrients for long-term health and well-being.
LifePak is a comprehensive nutritional wellness program delivering the optimum amounts of all essential and generally beneficial nutrients for long-term health and well-being.
LifePak is unique, because it is a complete wellness supplement!

3. LifePak Health Benefits
Optimum supplementation for general well-being
1. Addresses nutrient deficiencies
2. Cardiovascular benefits
3. Complete bone nutrition
4. Promotes healthy immune function
5. Supports blood sugar metabolism
6. Protects against the symptoms of aging
7. Raises your antioxidant defense
Because LifePak provides optimum supplementation, it has many more health benefits than typical multivitamins:
It addresses all possible nutrient deficiencies,
has cardiovascular benefits,
provides complete bone nutrition,
promotes healthy immune function,
supports blood sugar metabolism,
protects against the symptoms of aging
and raises your antioxidant defense.
These are the 7 main health benefits of LifePak.

4. 1. Nutrient Deficiencies
Multivitamins are an important aspect of healthy living. While we know what constitutes a healthy diet, there are not many of us that do so on a regular basis. In a nationwide survey conducted by the USDA, they found that adults are not even meeting the RDA for essential vitamins and minerals. Note that a number of the low nutrients are intimately involved in promoting immune health, including vitamin A, vitamin C, vitamin E, and vitamin B6. And look at iron intake for women… extremely low.

5. 1. Nutrient Deficiencies
Multivitamins are an important aspect of healthy living. While we know what constitutes a healthy diet, there are not many of us that do so on a regular basis. In a nationwide survey conducted by the USDA, they found that adults are not even meeting the RDA for essential vitamins and minerals. Note that a number of the low nutrients are intimately involved in promoting immune health, including vitamin A, vitamin C, vitamin E, and vitamin B6. And look at iron intake for women… extremely low.

6. 2. Cardiovascular Benefits
Over 40 Antioxidants: protect blood lipids (LDL) from oxidation by free radicals
Oxidized LDL clings
to artery lining,
causing plaque build-up
Artery
Now, let’s talk about the cardiovascular benefits. LifePak provides the optimum amounts of over 20 different antioxidant nutrients that work together in the body to protect the LDL blood lipids from oxidation by free radicals.
You probably know that LDL-cholesterol is the bad cholesterol you want to keep low. But what’s even worse is when this LDL-cholesterol becomes oxidized in the body. As you can see here--oxidized LDL particles stick to the inner artery walls and cause plaque build-up.
LifePak is clinically proven to make LDL particles more resistant against oxidation by free radicals. This is shown on this graph. LifePak makes the LDLs less clingy, and that’s a huge cardiovascular health benefit!
I call this one of “LifePak’s Silent Benefits;”they are silent, because you can’t feel it at first, but trust me: you will reap the benefits years later.
Blood Pressure (Ca, Mg)
Circulation (Flavonoids)
Inflammation (Flavonoids, Aox)
Homocysteine (B-Vitamins)

7. 3. Bone Nutrients
Here, you see the enlarged structure of a healthy bone. You see a strong architecture of bone substance.
Unfortunately, many of us have bones like this, where the structures are thinner than normal.
When you have osteoporosis, your bone structure is very weak, as you can see here. There is a high risk of bone fractures.
Osteoporosis is a growing concern in Taiwan. There are now over three times more people diagnosed with osteoporosis in Taiwan than 15 years ago.
US & EU: 23 million bone fractures per year due to osteoporosis = $27 billion medical costs

8. 3. Bone Nutrients
Calcium (500 mg): Major bone mineral; RDA: mg/day; typical intake: 800 mg/day
Magnesium (250 mg): Major bone mineral; RDA: mg/day
Vitamin D (400 IU): Regulates Ca & Mg bone metabolism; deficiencies in Northern latitudes
Vitamin K (40 mcg): Ca transport into bone
Silicon (3 mg): Bone calcification & collagen
Boron (3 mg): Regulates bone cell function
Soy Isoflavones (5 mg): Reg. Ca metabolism
Most people know that calcium is important for healthy bones, and that getting enough calcium from the diet can prevent osteoporosis. Unlike typical multivitamins, LifePak contains 500 mg calcium to make sure that virtually everybody taking it will meet the optimum calcium recommendations by the major health authorities. But calcium alone is not enough. You need to have ALL other bone nutrients as well:
Magnesium, another major bone mineral,
Vitamins D and K, which regulate bone metabolism, and the
Phytoestrogens from soybeans, which promote the incorporation of minerals into the bone.
LifePak has the right amounts of these and more nutrients to make sure your bones stay healthy throughout your life.

9. 4. Immune Function LifePak promotes normal immune function
Vitamins A, C & E, Carotenoids, Vitamin B6 & Zinc

10. 5. Blood Sugar & Insulin
LifePak promotes normal blood sugar, glucose tolerance and insulin metabolism
Chromium, 200 mcg:
essential for normal insulin function
most diets are low in chromium (<50 mcg/day)
Vitamin C, 500 mg
Vitamin E, 300 IU
Alpha-Lipoic Acid, 30 mg
Magnesium, 250 mg
Zinc, 15 mg

11. 6. Aging Symptoms DNA Damage
LifePak Addresses the Root Cause of Aging:
DNA Damage
DNA (DeoxyriboNucleic Acid) is your genetic blueprint
DNA enables healthy cell renewal into old age
Now let’s turn to the new anti-aging benefits of LifePak. It’s really important for you to understand that LifePak addresses the root cause of aging, and that is DNA damage.
DNA stands for deoxyribonucleic acids. DNA is present in every body cell and it stores all your genetic information. DNA is the blueprint from which new cells are created and old ones regenerated.
DNA enables healthy cell renewal into old age.
Let me give you some more background information...

12. Weak Antioxidant Defense Free Radical Production
How Do We Age?
Body Cell
Mitochondria
Cell Nucleus
Weak Antioxidant Defense
DNA Damage
Free Radical Production
DNA Damage
Impaired Cellular Function and Cell Regeneration
Impaired Energy Production
Now, let’s summarize how we age:
Here is a typical body cell…
… which has a nucleus and mitochondria, both containing DNA.
As we age, our antioxidant defense system becomes weaker...
… leading to more free radical damage to DNA, which causes...
… impaired cellular function and regeneration.
At the same time, the large amounts of free radicals produced in the mitochondria damage mitochondrial DNA…
… which leads to impaired energy production, …
… which also impairs cellular function and regeneration.
which in turn leads to the appearance of aging symptoms.
Aging Symptoms

13. an arsenal of nutrients that fight DNA damage,
LifePak provides
an arsenal of nutrients that fight DNA damage,
protect DNA, and
enhance DNA repair.
Transition:
Let’s look at a few of these nutrients!

14. Green Tea and Longevity
Consumption
(Cups/Day)
Prospective, 11-year cohort study of 8,552 subjects in Yoshimi, Japan, From: H. Fujiki et al., Ann. N.Y.Acad.Sci., 928:274, 2001; used with author’s permission

15. 7. Antioxidant Protection
Journal of the American Medical Association June 2002
“… low levels of the antioxidant vitamins (vitamins A, E, and C) may increase risk for several chronic diseases. Most people do not consume an optimal amount of all vitamins by diet alone.”
“It appears prudent for all adults to take vitamin supplements.”
As a result of nationwide nutritional intake surveys, and research in the last decade on antioxidant vitamins, the Journal of the American Medical Association released a landmark editorial in June of 2002 recommending that ALL adults take vitamin supplements.
Robert H. Fletcher, MD, MSc; Kathleen M. Fairfield, MD, DrPH, Harvard University Journal of the American Medical Association 2002; 287:

16. Free Radicals & Antioxidants
Highly reactive, short-lived molecules
Damage cells and genetic material (DNA)
70,000 free radical attacks on DNA every day in a cell
Aging process
Implicated in most health conditions
Many different types of free radicals
Before speaking about antioxidants, you need to know what free radicals are. They are highly reactive, short-lived molecules inside your body that can damage virtually all important biomolecules inside your cells, including your genetic material, the DNA.
Antioxidants, on the other hand, are there to protect the body from this free radical damage, because antioxidants can neutralize or scavenge free radicals. As a result, antioxidants have many health benefits and they can slow down the aging process. There are over 30,000 research studies showing how antioxidants can affect over 50 health conditions, including cardiovascular function, eye health, central nervous system function, skin health and more.

17. Sources of Free Radicals
Metabolism in your mitochondria
Environmental pollution (smog, ozone, NO2)
Radiation exposure:
sunlight (UV-light), X-rays, etc.
Smoking:
10,000,000,000,000,000 free radicals/cigarette!
What are the sources of free radicals in our body?
The major source of free radicals is through your normal energy metabolism. Inside your cells are many little structures called mitochondria. These mitochondria are the power plants of your cells. They take the oxygen we breathe and the food calories we eat and convert them into usable cellular energy called ATP. Unfortunately, the mitochondria also produce a lot of free radicals: about 2-5% of the oxygen we breathe is converted into free radicals.
Free radicals also come from environmental pollution, such as ozone gas, as well as from radiation exposure (UV-light, X-rays) and of course from cigarette smoking. Each cigarette releases 10 quadrillion free radicals into your lungs! This is the main reason why smokers age so much faster than non-smokers.

18. Free Radicals & Antioxidants
Antioxidants fight free radicals
Slow down aging process & improve health:
over 30,000 research studies on antioxidant health benefits
affecting over 50 health conditions, incl.cardiovascular function, eye health, CNS health, skin health, etc.
Many antioxidants work together: “Antioxidant Defense System”
Relies on a steady supply of dietary antioxidants
Before speaking about antioxidants, you need to know what free radicals are. They are highly reactive, short-lived molecules inside your body that can damage virtually all important biomolecules inside your cells, including your genetic material, the DNA.
Antioxidants, on the other hand, are there to protect the body from this free radical damage, because antioxidants can neutralize or scavenge free radicals. As a result, antioxidants have many health benefits and they can slow down the aging process. There are over 30,000 research studies showing how antioxidants can affect over 50 health conditions, including cardiovascular function, eye health, central nervous system function, skin health and more.

19. LifePak 40+ Antioxidants
All 8 forms of natural vitamin E: 300 IU
Buffered vitamin C: 500 mg
Selenium, Copper, Zinc, Manganese
6 Carotenoids:
as found in 5-10 fruits & vegetables per day
Over 20 Flavonoids:
6 Catechins, Quercetin, naringenin, hesperidin, Soy isoflavones, Over 10 grape seed polyphenols
Alpha-Lipoic Acid: mg
LifePak provides many different types of antioxidants to combat many different types of free radicals - this is how LifePak promotes your entire antioxidant defense network. It provides clinically-significant doses of your antioxidant vitamins, mineral cofactors, multiple sources of carotenoids, over 20 flavonoids, and novel antioxidants, such as alpha-lipoic acid.

20. LifePak Clinical Study Antioxidant and Cardiovascular Health
Beta-carotene
LDL Protection
LifePak was subject to 2 double-blind, placebo-controlled clinical studies. Results from these studies showed that LifePak significantly increases serum levels of our antioxidant vitamins - so they are bioavailable - and was also shown to decrease LDL cholesterol oxidation - a known risk factor for cardiovascular disease.
Vitamin E
Smidt CR, Seidehamel RJ, Devaraj S, Jialal I. FASEB Journal Vol.13 No.4, p.A546, March 1999.
Full study report available upon request.

21. LifePak Antioxidant Capacity (ORAC) Jan 2003
Recommended daily antioxidant intake (R. Prior, USDA)
LifePak has been subject to ORAC testing, which measure the antioxidant capacity of foods. Dr. Prior, the lead researcher for ORAC at the USDA suggests that Americans have a 2000 ORAC “gap” between the antioxidant protection they get from their diet and the antioxidant protection that they need. LifePak provides a level of antioxidant capacity that fills this ORAC gap, and was much higher than a sample of competitors.

22. LifePak® - The Measurable Difference
First to show antioxidant and cardiovascular benefits in double-blind studies
200,000+ published studies on LifePak’s antioxidants
Nearly 800,000 published studies on all LifePak ingredients
LifePak is built upon scientific consensus
Hundreds of thousands of independent studies verify the positive effects of LifePak’s antioxidants and nutrients. The LifePak formula was the first multivitamin/mineral supplement to be clinically tested and show positive results for antioxidant and cardiovascular health.

23. Pharmanex BioPhotonic Scanner
Measures Skin Carotenoids
Indicator of Antioxidant Status
Indicator of healthy diet/lifestyle
Rapid & Non-Invasive
Scientifically Validated
Another validation of LifePak, which you are probably more familiar with, is the BioPhotonic scanner. This is a way that our distributors and contacts can prove the effects of LifePak in their own body. Pharmanex has completed three clinical studies, with more in progress, to validate the biophotonic measurement as an important health indicator, and to validate the effect of LifePak on Scanner scores.

24. Scanner Science is Measurable
New York Academy of Sciences, Feb 2003
Oxygen Club of California, Feb 2003 and Feb 2004
FASEB/American Society of Nutritional Sciences - April 2003 and April 2004
Gordon Research Conference, Jan 2004
Review paper published in Current Topics in Nutraceutical Research, May 2004 (available at
Pharmanex Scientists have presented the science behind LifePak and the BioPhotonic scanner and attended a number of scientific meetings this past year.
In February 03, Pharmanex Scientists joined with Dr. Werner Gellerman and Dr. James Rippe in a presentation at the New York Academy of Sciences.
In February 03 and 04, Pharmanex Scientists attended scientific meetings on antioxidants organized by the Oxygen Club of California in Cadiz, Spain, and Santa Barbara, CA. Dr. Lester Packer is the founder and honorary president of the Oxygen Club and chaired these meetings. Dr. Carsten Smidt presented a scanner study at the Santa Barbara meeting.
In April 03 and 04, Dr. Carsten Smidt attended the Federation of American Societites for Experimental Biology (FASEB) meetings in Sand Diego and Washington DC, and presented the results of two different scanner stuides.
In January of this year, Dr. Carsten Smidt attended and presented the scanner/serum correlation study at the Gordon Research Conference on Carotenoids in Ventura, California. Dr. Smidt also scanned 60 of the top antioxidant researchers in the world at this conference.

25. 2004 Data Histogram Smokers Average (2-3 Fruits & Vegetables) Obesity
Mean = 25,406
32,948 Subjects
Smokers
Average (2-3 Fruits & Vegetables)
Obesity
5-9 Fruits & Vegetables
Frequency
LifePak
Based on clinical studies with the biophotonic scanner, we have identified a number of factors that may influence your score. These include diet, antioxidant supplements, lifestyle, body fat level, and one uncontrollable factor - your genetic ability to absorb carotenoids. This data was originally identified in our original clinical screening study in September 2002, and has since been confirmed in subsequent studies in the U.S., Singapore, and Thailand.
Skin Carotenoid Score

26. 2004 Data: Fruits & Vegetables
Importantly, we found that skin carotenoids are not influenced by age, gender, or skin pigmentation (melanin).

27. 2004 Data: LifePak Usage
Importantly, we found that skin carotenoids are not influenced by age, gender, or skin pigmentation (melanin).

28. Body Fat - Inverse Correlation
Overweight individuals and anyone on a diet should increase antioxidant protection through diet and supplementation.
Our first clinical study on the scanner identified an interesting link between body fat levels and scanner scores. We have since been able to analyze the numbers from our global scan database and have found a strong inverse correlation - as body fat levels increase, scanner scores decrease.

29. Clinical Study - Sep 2002 LifePak  Scanner Score
Pharmanex completed a clinical screening study to show that LifePak supplementation impacted carotenoid antioxidant status, as measured by the biophotonic scanner. Participants in this study experienced a significant increase in scanner scores at 4, 8, and 12 weeks of LifePak supplementation - on average, their scores nearly doubled.

30. Carotenoid Correlation Study June 2003
Smidt CR, Gellermann W, Zidichouski JA; FASEB Journal 18(4) pt.I:A480, 2004

31. A Global Look: Average Scan Scores
We recently completed a clinical study in Singapore, which resulted in similar findings from our original screening study. We found the same type of data relationship, such as diet, supplements, body fat, and lifestyle. The average score was 25,000, slightly higher than the U.S., but this was attributed to the fact that 82% of the participants were taking LifePak (as opposed to 30% in the original U.S. study). Again, participants who consistently took LifePak twice daily scored higher than non-LifePak users.
* Internal data on file

32. Skin Carotenoid Scores
Example of a person reading 25,000:
RED: 19,000 and less: Poor diets, no/ineffective supplements, genetic factors, obesity, or smoking.
YELLOW: 20, ,000: Better diets and/or supplements.
GREEN: 30, ,000: Healthy diets rich in fruits & vegetables and/or good supplements.
BLUE: 40,000+: Excellent diets high in fruits & vegetables and excellent supplements.

33. Media Coverage in 2003 Self Magazine April 03 Elle Magazine Sep 03
Ms. Fitness Magazine Oct 03
NBC Today in LA
KNXV ABC News
Phoenix AZ News 3
WHDH-TV NBC Boston MA
WHAS 11 News Louisville KY
News All Morning New York
KUTV News Salt Lake City
NewsChannel 4 Columbus OH
CNBC Asia - Singapore
The scanner has received a wide variety of media coverage, such as the consumer magazines Self and Elle, as well as a number of tv news programs, such as NBC Today and CNBC Asia in Singapore.

34. LifePak Health Benefits
8. Helps maintain healthy eyes
9. Promotes healthy teeth and gums
10. Supports weight loss diets
11. Promotes skin function & protection
12. Prevents neural tube defects
13. Supports energy metabolism
14. Helps maintain mental performance
plus more...
However, LifePak has many other health benefits, and I can easily add on another seven, for example:
Helps maintain healthy eyes (lutein, antioxidant vitamins, zinc…)
Promotes healthy teeth and gums (periodontal health)
Supports weight loss diets
Promotes skin function & protection
Prevents neural tube defects (folic acid, inositol)
Supports energy metabolism
Helps maintain mental performance

35. Comprehensive & Convenient
Better than these 7 popular supplements together.
Multi
Carotenes
Multi
Vitamin
Vitamin E
300 IU
>
Chromium
200 mcg
Vitamin C
500 mg
Calcium &
Magnesium
Finally, LifePak is a highly convenient and comprehensive product. It has many more benefits than these 7 popular supplements together, and ultimately costs a lot less too. If you go into a health food store and try to match LifePak’s composition with individual products, you can easily spend more than $200/month, and you still will not achieve the balance and quality of LifePak.
Multi
Flavonoid

36. Thank you.
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