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Implementation Science: An Emerging Field Bryan J. Weiner, Ph.D. Professor Department of Health Policy and Management
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A Roadmap for Today’s Talk Why implementation science? What is implementation science? What does implementation science look like? How do you do implementation science? Where can I learn more? 2
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Why Implementation Science? 3
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A Growing Evidence Base of What Works 4
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And Yet… Americans receive “recommended care” approximately 50% of the time (McGlynn et al., 2003). Between the health care we have and the care we could have lies not just a gap, but a chasm (IOM, 2001). 5
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And in Cancer Care… Completion rate of 3-dose HPV vaccine: –33% for teenage girls –7% for teenage boys 6
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And in Cancer Care… Surgery rate for non-small cell lung cancer: –14% lower for Blacks than whites 7
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And in Cancer Care… Over-surveillance rate among patients with non-displastic Barrett’s Esophagus –65% in a multi-center study 8
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Barriers to Evidence-Based Practice and Policy 9
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What is Implementation Science? 10
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11 What is Implementation Science? IMPLEMENTATION SCIENCE is the study of methods to promote the use of research findings in healthcare, community, and policy contexts. As a multidisciplinary field, it examines how these findings are disseminated, implemented, and sustained by targeted audiences. Figure modified from National Cancer Institute Implementation Science Web Portal and Rubenstein et al. 2006.
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Dissemination and Implementation Dissemination: the targeted distribution of information and intervention materials to a specific public health audience or clinical practice audience Implementation: the use of strategies to adopt and integrate evidence-based health interventions and change practice patterns in specific settings. NIH PAR 07-086 12
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IS as an Emerging Field 13
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IS as a Translational Science Modified from Khoury et al. Figure 1—Knowledge integration process. 14
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IS as a Team Science 15
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What does IS look like? 16
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Examples of Funded IS Grants Implementing evidence to prevent urinary infection and enhance patient safety Increasing implementation of evidence- based interventions at low-wage worksites Integrating tobacco use treatment guidelines in dental public dental clinics Implementing EBAN II: an evidence-based intervention for sero-discorant couples 17
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Two Examples In My Work Examining the implementation, impact, sustainability, and business case of the CCOP, a federally funded provider-based research network Increasing colorectal cancer screening rates in community health centers through practice change facilitation and an evidence- informed tool kit 18
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NCI IS Portfolio Review 19 Neta et al., (2015). Implementation science in cancer prevention and control: a decade of grant funding by the National Cancer Institute and future directions. Implement Sci, 10(1), 4. doi: 10.1186/s13012-014-0200-2
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NCI Portfolio Review- Implementation Science 67 grants included in Implementation Science portfolio review, funded between 2000-2012 20 Cancer Control Continuum # of grants % of grants Prevention3349.3% Screening2740.3% Cross-cutting710.4% Survivorship46% Treatment34.5% Diagnosis00% Types of Cancer/ Risk factors # of grants % of grants Tobacco2638.8% Colorectal cancer2029.9% Breast cancer1217.9% Cervical cancer811.9% Physical activity69% Diet/nutrition57.5% Sun safety57.5% Public health genomics46% Obesity34.5% *Numbers may add up to more than 67 (100%) in some cases because a given grant may fit into more than one category. Neta et al., 2015
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NCI Portfolio Review- Implementation Science 21 Implementation Science Objectives# of grants% of grants Implementation5379.1% Dissemination3146.3% Sustainability2638.8% Adoption2029.9% Sustainability Indicators# of grants% of grants Maintenance2537.3% Capacity building2029.9% Cost analysis1522.4% *Numbers may add up to more than 67 (100%) in some cases because a given grant may fit into more than one category. Neta et al., 2015
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Funding Trends for NCI-funded IS 22 Funding trends of NCI-funded implementation science by grant mechanism, fiscal years 2000-2012 (Neta et al., 2015)
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How do you do IS? 23
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When to Do IS 24
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Study Designs Experimental designs –Individual/cluster RCT, MOST, SMART, hybrid Quasi-experimental designs –interrupted time series, regression discontinuity Observational designs –surveys, focus groups, case studies Mixed methods 25
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Hybrid Designs Adapted from Curran et al., 2010 26
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Provider-directed interventions –Interactive education –Reminders –Decision support –Audit & feedback –Opinion leaders 27 Implementation Strategies
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Staff-oriented interventions –Multi-disciplinary teams –Revised roles –Case management 28 Implementation Strategies
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Patient-mediated interventions (“pull”) –Education –Navigation –Reminders –Decision aids 29 Implementation Strategies
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Regulatory interventions –Accreditation –Licensure –Insurance coverage 30 Implementation Strategies
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Financial interventions –Payment changes –Incentives 31 Implementation Strategies
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Organizational interventions –Structural changes –Service changes –Quality Improvement 32 Implementation Strategies
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Collaboratives / campaigns –Hospital-to-Home Campaign –IHI Breakthrough Series –Vermont Oxford Network –5 Million Lives Campaign 33 Implementation Strategies
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34 Implementation Outcomes Types of outcomes in implementation research Adapted from Proctor et al., 2011
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Implementation in low-resource settings Reliable, valid, and practical measures Cost and cost-effectiveness studies Strategies for scaling up effective programs Use of simulation models to evaluate proposed D&I actions, policies, and practices Theory and research on sustainability De-implementation 35 Gaps & Opportunities
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Where can I learn more? 36
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Sample Grants and Grant Writing Resources Sources of Evidence Tools Measures Journals Theories and Frameworks Conferences and Training Presentations 37 D&I Portal – an NC TraCS Resource http://tracs.unc.edu/di-portal
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Consortium for Implementation Science 38 Advance IS through research, practice, policy, and education/training Initial focus: improving health in the US Approach: –Identify opportunities and connect investigators –Build cross-institutional research teams –Scientific/technical support for proposals –Facilitate access to internal funds for pilot projects http://consortiumforis.org/
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The Implementation Network http://www.implementationnetwork.com/ Monthly e-newsletter and website 1500+ members worldwide Supported by VA QUERI and NCI Chief Editor: Wynne Norton, Ph.D. 39
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http://www.seattleimplementation.org/sirc- projects/sirc-instrument-project/ http://www.seattleimplementation.org/sirc- projects/sirc-instrument-project/ Comprehensive library Evidence-based assessment Consensus battery Lead Investigator: Cara Lewis, Ph.D. (Indiana University, Bloomington) 40 SIRC Instrument Review Project
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Grid-enabled Measures (GEM) D& I Workspace https://www.gem-beta.org/public/wsoverview.aspx?wid=11&cat=8 CFIR Wiki http://www.wiki.cf-ir.net/index.php?title=Main_Page SIRC (focus on behavioral therapies) http://www.seattleimplementation.org/ Implementation Science Journal http://www.implementationscience.com/ VA Enhancing Implementation Science Webinar archives http://www.queri.research.va.gov/meetings/eis/ 41 Other D&I Resources
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bryan_weiner@unc.edu 919-537-8111 Thank you
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NCI Portfolio Review- Implementation Science 43 Frameworks/ Models# of grants % of grants Diffusion of Innovation 2638.8% RE-AIM 2334.3% Chronic Care Model 710.4% Organizational Change 710.4% Systems/Network Theories 57.5% Model of Diffusion in Service Orgs 34.5% Methods Used# of grants % of grants Quantitative5988.1% Qualitative5480.6% Comparative effectiveness 3552.2% Cost analysis1826.9% Simulation models23% Network analysis11.5% *Numbers may add up to more than 67 (100%) in some cases because a given grant may fit into more than one category. Neta et al., 2015
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Funding Trends for NCI-funded IS 44 Trends in NCI-funded grants in implementation science by funding announcements, fiscal years 2000-2012 (Neta et al., 2015)
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Success Rates 45 Neta et al., 2015
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New Investigator Awards 46 Neta et al., 2015
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