1. WELCOME TO The BREW Project Medium and long-term opportunities and risks of the biotechnological production of bulk chemicals from renewable resources Fraunhofer ISI Institute Systems and Innovation Research CERISS

2. BREW - Organisational issues 1. Consortium 2. Finances & roles of partners 3. Contract changes 4. Product overview 5. Book proposal 6. BREW website (members‘ section) 7. Cost statements 8. Time plan

3. 1. Consortium Dechema taking over conference (WP9) ACTIN out, UU taking over Projection of the market potential (WP 6)

4. 2. Finances & roles of partners No financial contribution to Dechema for organizing conference (but EUR 5000 for inviting experts from abroad) Saved funds for calculating investment costs of biorecovery by DSM

5. 3. Contract changes (revised DoW not yet submitted to EU) Extra funds for DSM for investment costs Degussa and novozymes IN Actin OUT UU takes over WP 6 from Actin, more consumables More travel funds for UCM DuPont as “Full cost” partner ATO  A&FI Contract extension to May 2005

6. 4. Product overview / BREWtool (1/2) ATO  (Biotech) Hydrogen  PHA  Lysine: OUT  Adipic acid: Generic approach BP  Acetic acid (via ATO)  Support on petchem. data Cargill DOW  LA  PLA  Corn growing  CWM  IFEU (anaerobic digestion?), NREL?, DSM  various petchem. and biotech products DuPont  PDO Shell  Ethylene (via bioethanol)  LA  Ethyl lactate  Methyl ethyl ketone  Adipic acid

7. 4. Product overview / BREWtool (2/2) UCM  Diglycerol monooleate (biosurfactant)  Diglycerol monolaureate (biosurfactant)  Glycerol monopalmitate (biosurfactant)  Glycerol monoricinolate (biosurfactant)  Glycerol monooleate (biosurfactant)  Oleyl oleate (biolubricant)  Isopropyl myristate (Cosmetics)  n-Octyl octanoate (Cosmetics) – Ester  Maybe: Biodiesel from used frying oils and methanol  Products obtained by nucleophilic enzymatic opening of epoxides (intermediates of pharmaceutical products e.g. polyfunctionalized molecules) Uniqema Multiple products from enzymatic processing pathways.  Splitting of fats and oils to a) fatty acid b) glycerin (co-product: RME)  Transesterification of rapeseed oil with methanol  natural alcohol ex methylester  surfactant production Novozymes  see above Roquette  LCA starch to glucose/dextrose Degussa  PDO (pchem)  Acrylamide (biotech)

8. 5. Book proposal Reviews received Decision tomorrow

9. http://www.chem.uu.nl/brew username: brewer password: bulk Second edition of the Description of Work Section “BREW Book Publication”: First book proposal Crank, M. et al.: Techno-economic Feasibility of Large-scale Production of Bio-based Polymers in Europe (PRO-BIP) Andringa, L.: Analysis of technology policy and systems of innovation approach: the case of biopolymers in the United States, M.Sc. Thesis Utrecht University/University of Oklahoma Recent publications by others (e.g., JoIE) Upcoming conferences 6. BREW website, members‘ section

10. 7. Cost statements Cost statements only received from: Fraunhofer, novozymes AND A&FI Please ask you administration to send A.S.A.P. !

11. 8. Time plan (1/2) Substructure interim report circulated by 18 JUNE Final decision about substructure interim report by 30 JUNE Fourth plenary meeting: SEPT/OCT 2004 Fifth plenary meeting: DEC/JAN 2005? Conference: 10-12 MAY 2005

12. 8. Time plan (2/2)