1. The National Children’s Study A Very Brief History Spring 2000 – Interagency Coordinating Committee established October 2000 – Children’s Health Act authorizes NCS December 2000 – First Assembly meeting October 2001 – Advisory Committee established under FACA 2001-2004+ – Working groups (22) focus on hypotheses and measures development 2002-2004 – Sample considerations – national probability sample announced June 2004 Fall 2003 – Expansion of Program Office Staff June 2004 – April 2005 – Advisory committee pause for procurement November 16, 2004 – Hypotheses, Study plan, Study sites, Coordinating Center RFP, Vanguard Centers RFP

2. NCS Brief History (cont.) 2005 – 7 Vanguard Centers and Coordinating Center awarded to pilot the protocol 2007 – 17 new Centers and 40 new Locations established for Wave I 2008 Funding NCS for $110.9 M National Academy of Sciences review of Research Plan 39 Wave II Study Centers and Locations awarded New National NCS website launched More than 2,500 individuals contributed to the scientific development thus far

3. NCS Brief History (cont.) 2009 Vanguard Centers begin participant recruitment for 18- month pilot phase July – First birth in NCS Wave I and II deceleration Administrative Reorganization Fall – 16 total births Fall – 43,000 enumeration interviews are finalized Fall – 21,000 women identified as eligible for pregnancy screener Fall – 16,500 have completed the screener Fall – 210 pregnant women have agreed to participate Fall – All Vanguard Centers participated in staff training events for the P1 visit