1. Asthma By: Emily Ngo

2. Asthma Background Asthma is a chronic disease that affects up to 150 million people in the world Asthma is an inflammatory disease in the lungs that causes constriction in the airways Like many other diseases, asthma can be controlled but not cured

3. Asthma background cont’d… Many cells contribute to the inflammation The inflammation causes wheezing, coughing, chest tightness, and breathlessness

4. What happens in the lung?

6. Cells that cause inflammation lymphocyte eosinophil mast cell epithelial cell fibroblast macrophage neutrophil T-lymphocyte

7. Cells that cause inflammation

8. T-lymphocytes produce cytokines… Cellular Immunity TH1: IL-2, INF-γ Allergic Inflammation TH2: IL-4, IL-5, IL-10, IL-13 *What if there is a balance/imbalance of TH1/TH2?

9. Hygiene Hypothesis

10. Protect your baby, let your baby play with animals!

11. Relationship of Allergy to Asthma

12. Role of Allergy in Development of Asthma

14. Treatments Asthma Therapy:  Environmental Controls  Immunotherapy (Allergy Injections)  Symptomatic Control (bronchodilating agent)  Disease Modifiers (affect inflammation)

15. Environmental Control Measures Allergen Avoidance House Dust mites Grass Pollen Indoor Pets Feathers and Down

16. Allergen Immunotherapy