1. By: Amy Marston, Abby Drees, Bobby Wachtel, and Yianni Troupes

2.  Thyroid –Stimulating Hormone is produced by the pituitary gland

3.  Thyroid-Stimulating Hormone is peptide based, as shown it needs a receptor and cannot pass through the membrane

4.  The second messenger for TSH is cyclic AMP

5.  After a phosphorylation cascade occurs, TSH stimulates a change in the thyroid cell’s DNA so that it begins to produce the hormone “thyroxine”

6.  The result of this pathway is a negative feedback loop  When the body needs more heat or experiences low thyroxin levels, TRH is released from the hypothalamus which stimulates the release of TSH from the anterior pituitary which then stimulates the release of thyroxin from the thyroid gland which increases metabolism and brings the body back to homeostasis.

7.  Grave’s Disease: An autoimmune disease where the body makes an antibody called TSI that mimics TSH, and causes the thyroid to make too much thyroid hormone.  This “hyperthyroidism” can result in a metabolism that is too high, and can result in weight loss, weakness, and even heart problems.

8. dd