1. PHARMACEUTICAL CHEMISTRY RESEARCH PROJECTS 2013 ;

2. RESEARCH AREAS  1. Drug Design & Discovery  (Dr. J. Joubert & Prof. S. Malan)  2. Drug Synthesis & Biological Evaluation Against pathogenic Microbes (Dr. J. Joubert & Prof S. Malan)  4. Phytochemistry (Prof P. Eagles)

3. 1. Drug design and Discovery – Neuroprotective Compounds Drug design, Biological activity and physical-chemical properties. Dr. J. Joubert, Prof. S.F. Malan and co-workers

4. Targets for Neuroprotection  Calcium homeostases –Calcium channels –NMDA receptor channels  Enzyme systems involved in neurodegeneration  Oxidative cascade, NOS and MAO-B. NOS-reaction

5. Research within drug design –Lead compounds  Chemical synthesis, drugs in use  New compounds from plants –Molecular modeling –Synthesis and characterization –Biological activity  In vitro  In vivo

6.  Protein modeling –Receptor / Enzyme fit  ‘Ligandfit’  ‘Docking’ Molecular modeling

7. Synthesis and Characterisation Synthesis and characeterization with NMR, MS and IR.

8. Biological evaluation - In vitro & In vivo

9. 2. Synthesis of Novel/Hybrid Molecules & Biological Evaluation – Malaria and Dengue fever  Inhibitory Activity  Resistance reversal in Microorganisms  Microscopic evaluation  Molecular Studies

10. 3. PHYTOCHEMISTRY- Prof Eagles  Phytochemistry is the study of phytochemicals produced  in plants, describing the isolation, purification, identification, and  structure of the large number of secondary metabolic compounds  found in plants.  Techniques commonly used in the field of phytochemistry  Thin layer chromatography (TLC)  Gel (column chromatography)  High performance of liquid chromatography (HPLC)  Gas chromatography (GC)  Mass spectrometry