1. Corporate EHS Strategic Perspective
Michael Rottas
Associate Director, Environmental Health & Safety
Pfizer Global R&D – Groton/New London Laboratories

2. Pfizer is the largest pharmaceutical company in the world.
Human health
Consumer health care
Animal health
~120,000 employees worldwide
Operations in 150 countries
Largest privately funded research organization in the world.
Now ~$8 billion/year
Groton Labs ~$1.5 billion/year

3. Global Environmental Management Initiative (GEMI) member
UN Global Compact member
EPA Climate Leaders participant
Public Environmental Goals:
Reduce CO2 emissions by 35% by 2007 (2000 as baseline)
35% of global electricity needs by 2010 from clean sources
Phase out of Class I ODCs by 12/31/2005

4. Where we were…
EHS professionals, in Corporate setting, were necessary overhead due to compliance requirements
Outsiders from manufacturing and operating units
Us vs. them
Niche role
Reactive
After the fact
End-of-line control

5. Where we are…
EHS professionals are a respected participant in the business process
We are at the table
Resource for business risk minimization and continuity planning (post Y2K, post 9/11/2001)
Skills transferable, financially savvy
Proactive and preventative
Third party EMS registrations

6. Where we are going… Holistic approach to sustainable practices
Integrated EHS management systems
No longer separate, but integrated into core business functions
Technical professionals with sophisticated business skills (MBAs routine)
Everyone is involved, cultural approach

7. Industrial Evolution
Sustainability becoming more commonplace within the core business of leading businesses
Hybrid cars becoming mainstream
Petrochemical companies working on alternative fuels
Carpet companies making recyclable carpets
Pharmaceutical companies doing green chemistry
Investment firms recognize value in sustainable practices

8. What is green chemistry?
“…the utilization of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products.”
*Source: Paul T. Anastas and John C. Warner, Green Chemistry: Theory and Practice (New York, NY: Oxford University Press Inc., 1998).
ISBN

9. 12 Principles of Green Chemistry*
It is better to prevent waste than to treat or clean up waste after it has formed.
Synthetic methods should be designed to maximize the incorporation of all materials used in the process into the final product.
Wherever practicable, synthetic methodologies should be designed to use and generate substances that possess little or no toxicity to human health and the environment.
Chemical products should be designed to preserve efficacy of function while reducing toxicity.
The use of auxiliary substances (e.g. solvents, separation agents, etc.) should be made unnecessary wherever possible and innocuous when used.
Energy requirements should be recognized for their environmental and economic impacts and should be minimized. Synthetic methods should be conducted at ambient temperature and pressure.

10. 12 Principles of Green Chemistry*
A raw material or feedstock should be renewable rather than depleting wherever technically and economically practicable.
Unnecessary derivatization (blocking group, protection/deprotection, temporary modification of physical/chemical processes) should be avoided wherever possible.
Catalytic reagents (as selective as possible) are superior to stoichiometric reagents.
Chemical products should be designed so that at the end of their function they do not persist in the environment and break down into innocuous degradation products.
Analytical methodologies need to be further developed to allow for real-time, in-process monitoring and control prior to the formation of hazardous substances.
Substances and the form of a substance used in a chemical process should be chosen so as to minimize the potential for chemical accidents, including releases, explosions and fires.

11. PGM Global R&D Raw Materials Energy Natural Resources Product NDA
Intellectual
Property
Raw Materials
Waste
Energy
Global R&D
Clinical Supply
Natural
Resources
Air Emissions
Solid/Hazardous
Wastes
Wastewater

12. PGM Waste Minimization Pollution Prevention Global R&D
Raw Materials
Energy
Natural Resources
Product
NDA
PGM
Intellectual
Property
Raw Materials
Waste
Energy
Global R&D
Clinical Supply
Natural
Resources
Air Emissions
Control at the source,
treat on or off-site,
recycle where possible.
Reduce, reuse, recycle.
Solid/Hazardous
Wastes
Wastewater
Waste Minimization
Pollution Prevention

13. Green Chemistry PGM Waste Minimization Pollution Prevention Global R&D
Raw Materials
Energy
Natural Resources
Product
NDA
PGM
Intellectual
Property
Raw Materials
Waste
Energy
Global R&D
Clinical Supply
Natural
Resources
Air Emissions
Solid/Hazardous
Wastes
Wastewater
Waste Minimization
Pollution Prevention

14. Sertraline (Zoloft)
Solvent use reduced from 60,000 to 6,000 gallons per ton of sertraline
Eliminated the use of 440 metric tons of titanium dioxide per year
Eliminating the use 150 metric tons of 35% hydrochloric acid per year
Eliminating the use of 100 metric tons of 50% sodium hydroxide per year
Increasing the efficiency of raw material, water and energy use
And, doubled the product yield.

15. Sertraline Process – Solvent Waste/Kg

16. EPA’s Presidential Green Chemistry Challenge Award - 2002

17. How the amount of waste produced in the manufacture of sildenafil (L of waste/kg of product) has decreased over the past 13 years.
Pyridine
Toluene
t-Butanol
2-Butanone
Ethyl Acetate
Ether
Methanol
Ethanol
Acetone
Methylene Chloride
1816 L/kg
139 L/kg
31 L/kg
10 L/kg
Medicinal
Optimized
Commercial Route
Commercial Route
Chemistry
Med. Chemistry
(1997)
following solvent
1990
1994
recovery

18. Who “does” green chemistry?
Chemists
EHS folks may assist with making the business case and providing inspiration/recognition, but ultimately it’s the chemists who do this.
Example of integration

19. Why Green Chemistry? Meets the challenge of the triple bottom line:
Economic
Social
Environmental

20. Green Chemistry & TBL Economic Aspect Lower cost of raw materials
Lower costs for environmental permitting and regulatory requirements
Lower costs on engineering controls for employee safety
Risk of loss due to accidents, on a macro perspective, decreases
Lower costs for environmental emissions control and treatment
Lower costs associated with inventory control
Competitive advantage

21. Green Chemistry & TBL Social Aspect
Fence line issues (odors, unplanned releases)
Resource sustainability for future generations
Public outreach/education programs
Pfizer reputation – they expect us to do this

22. Green Chemistry & TBL Environmental Aspect
More efficient use of non-renewable natural resources
Less impact on the environment due to permitted wastewater discharges, air emissions, and hazardous waste treatment
Less risk of incidents and unplanned releases
Smaller environmental footprint

23. The Nobel Prize in Chemistry 2005 The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2005 jointly to Yves Chauvin Institut Français du Pétrole, Rueil-Malmaison, France, Robert H. Grubbs California Institute of Technology (Caltech), Pasadena, CA, USA and Richard R. Schrock Massachusetts Institute of Technology (MIT), Cambridge, MA, USA “for the development of the metathesis method in organic synthesis.”