1. Efficacy of ampicillin plus ceftriaxone vs ampicillin plus gentamicin for Enterococcus faecalis infective endocarditis (EFIE) Multi-centre, observational, non-randomised, comparative cohort study (Spain, Italy; 2005-2011): N=291 adult pts with EFIE Fernández-Hidalgo N et al. Clin Infect Dis 2013;56:1261-8 1 of 2

2. Efficacy Safety Subgroup of pts with EFIE caused by non-HLAR strains: similar results, except for septic paravalvular complications: AC: 40% - AG: 26% (P=0.050) Efficacy of ampicillin plus ceftriaxone vs ampicillin plus gentamicin for Enterococcus faecalis infective endocarditis (EFIE) AC seems to have a similar efficacy as AG for treating EFIE patients regardless of HLAR status, but may be less nephrotoxic Fernández-Hidalgo N et al. Clin Infect Dis 2013;56:1261-8 2 of 2

3. Follow-up (FU) echocardiography after antibiotic therapy for infective endocarditis (IE): impact on retreatment of IE or cardiac valve surgery (CVS) Retrospective study (2005-2011): N=239 pts who survived initial treatment (Tx) for definite IE (Duke criteria) Schutte KM. IDWeek 2013 abs. 621 1 of 2

4. Follow-up (FU) echocardiography after antibiotic therapy for infective endocarditis (IE): impact on retreatment of IE or cardiac valve surgery (CVS) In 44 pts with Sx + ECHO: significant correlation between new findings on ECHO and need for retreatment for IE and/or CVS: P=0.002 In 23 pts requiring retreatment and/or CVS: TEE (71%) more sensitive than TTE (50%) for detecting worsening valve function or infection (P=0.0009) Valve type, location and infecting pathogen NOT significantly associated with need for retreatment or CVS IE patients with Sx at post-Tx FU should undergo TEE to guide decisions regarding retreatment of IE and/or CVS Schutte KM. IDWeek 2013 abs. 621 2 of 2