1. Supervised by : Dr. Adham Abutaha Presented by : Razan Abd Al-Nabi

2. Overview Mechanism of action Usage and indication Dosage and administration Precautions and important information Side effects Moxeza vs. other medications

3. Generic Name: moxifloxacin ophthalmic Active Ingredient: moxifloxacin hydrochloride Company: Alcon, Inc Date of Approval: November 19, 2010 Treatment for: Bacterial Conjunctivitis Bacterial Conjunctivitis A bacterial infection of a portion of the eye known as the conjunctiva. Common symptoms include redness of the eyes with a thick, often coloured purulent discharge.

5. Moxifloxacin is a member of the fluoroquinolone class of anti-infective drugs. it inhibits the topoisomerase II (DNA gyrase) and topoisomerase IV. (g-) (g+)

6. Moxeza solution is a topical fluoroquinolone anti- infective indicated for the treatment of conjunctivitis caused by susceptible strains of the following organisms: Aerococcus viridans, Corynebacterium macginleyi, Enterococcus faecalis, Micrococcus luteus, Staphylococcus sp., Streptococcus sp., Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Propionibacterium acnes, Chlamydia trachomatis

7. Off-lable uses - to treat bacterial eye infections other than conjunctivitis - to prevent any type of eye infection, such as a post- surgical eye infection.

8. Instill 1 drop in the affected eye(s) 2 times daily for 7 days Apply light pressure to the inside corner of the eye (near the nose) after each drop to prevent the fluid from draining down the tear duct

9. It is used to treat infections caused by bacteria only. Do not use Moxeza if you have had an allergic reaction to it or other similar medicines in the past Do not use other eye drops or medications during treatment with Moxeza unless otherwise directed by your doctor. cont.

10. If you wear contact lenses, remove them before applying Moxeza. Ask your doctor if contact lenses can be reinserted after application of the medication Moxifloxacin ophthalmic should only be used during pregnancy when benefit outweighs risk. Do not touch the dropper to any surface, including the eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in the eye

11. Serious side effects are not expected to occur during treatment with this medication. Some eye burning,irritation,fever ; or blurred vision may occur. Use caution when driving, operating machinery, or performing other hazardous activities

12. Vigamox ® is an older version of the same medication.However,Moxeza… - is formulated differently - only has to be used twice a day - is approved for treating bacterial conjunctivitis in children as young as four months old Other antibiotics… Other dosage forms…