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Implementing NICE guidance

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1 Implementing NICE guidance
Schizophrenia Implementing NICE guidance ABOUT THIS PRESENTATION: This presentation has been written to help you raise awareness of the NICE clinical guideline on schizophrenia: core interventions in the treatment and management of schizophrenia in primary and secondary care. This guideline has been written for healthcare professionals, including those from social care, and others who care for people with schizophrenia. The guideline is available in a number of formats, including a quick reference guide and an ‘Understanding NICE guidance’ version with information for patients and carers. You may want to hand out copies of the quick reference guide at your presentation so that your audience can refer to it. See the end of the presentation for ordering details. You can add your own organisation’s logo alongside the NICE logo. We have included notes for presenters, broken down into ‘key points to raise’, which you can highlight in your presentation, and ‘additional information’ that you may want to draw on, such as a rationale or an explanation of the evidence for a recommendation. Where necessary, the recommendation will be given in full. DISCLAIMER This slide set is an implementation tool and should be used alongside the published guidance. This information does not supersede or replace the guidance itself. PROMOTING EQUALITY Implementation of this guidance is the responsibility of local commissioners and/or providers. Commissioners and providers are reminded that it is their responsibility to implement the guidance, in their local context, in light of their duties to avoid unlawful discrimination and to have regard to promoting equality of opportunity. Nothing in this guidance should be interpreted in a way which would be inconsistent with compliance with those duties. 2009 NICE clinical guideline 82

2 Updated guidance This guideline updates and replaces:
‘Schizophrenia: core interventions in the treatment and management of schizophrenia in primary and secondary care’ (NICE clinical guideline 1 [2002]) ‘Guidance on the use of newer (atypical) antipsychotic drugs for the treatment of schizophrenia’ (NICE technology appraisal guidance 43 [2002]) NOTES FOR PRESENTERS: This guideline is an update of a previous guideline and also updates previous guidance on the use of newer (atypical) antipsychotic drugs for schizophrenia. Schizophrenia is commonly associated with a number of other conditions, such as depression, anxiety, post-traumatic stress disorder, personality disorder and substance misuse. NICE has produced separate guidance on the management of these conditions.

3 What this presentation covers
Background Scope Key priorities for implementation Costs and savings Discussion Find out more NOTES FOR PRESENTERS: In this presentation we will start by providing some background to the guideline and why it is important. We will then present the key priorities for implementation. The NICE guideline contains 10 key priorities for implementation, which you can find on pages 4 and 5 of your quick reference guide. The key priorities for implementation cover the following areas: Access and engagement Primary care and physical health Psychological interventions Pharmacological interventions Interventions for people with schizophrenia whose illness has not responded adequately to treatment. Next, we will summarise the costs and savings that are likely to be incurred in implementing the guideline. Then we will open the meeting up with a list of questions to help prompt a discussion on local issues for incorporating the guidance into practice. Finally, we will end the presentation with further information about the support provided by NICE.

4 Background (1) Schizophrenia is a major psychiatric disorder or cluster of disorders, characterised by psychotic symptoms. About 1% of the population will develop schizophrenia. The first symptoms tend to start in young adulthood. A diagnosis of schizophrenia is associated with stigma, fear and limited public understanding. There is a higher risk of suicide. NOTES FOR PRESENTERS: Key points to raise: The first symptoms usually occur when people are trying to make the transition to independent living. Psychotic symptoms alter a person’s perception, thoughts, affect and behaviour. The symptoms and behaviour associated with schizophrenia can have a distressing impact on family and friends. Each person with the disorder will have a unique combination of symptoms and experiences. The first few years after onset can be particularly upsetting and chaotic, and there is a higher risk of suicide. Additional information: Typically there is a prodromal period, often with some deterioration in personal functioning. This includes memory and concentration problems, unusual behaviour and ideas, disturbed communication and affect, and social withdrawal, apathy and reduced interest in daily activities. These are sometimes called ‘negative symptoms’. The prodromal period is usually followed by an acute episode marked by hallucinations, delusions, and behavioural disturbances. These are sometimes called ‘positive symptoms’, and are usually accompanied by agitation and distress. After the acute episode resolves, usually after intervention, symptoms diminish and often disappear, although sometimes negative symptoms remain. This phase can last for many years, and may be interrupted by recurrent acute episodes. This is a common pattern, but the course of schizophrenia can vary considerably. Some people may have positive symptoms very briefly while others may experience them for many years. Others have no prodromal period, the disorder beginning suddenly with an acute episode. Recent work indicates that young Caribbean men and African men, and middle-aged women from diverse ethnic or cultural backgrounds with schizophrenia are at higher risk of suicide. This may be due to differences in symptom presentation and conventional risk factor profiles across ethnic groups (Bhui and McKenzie 2008) (see the Disorder section of the full guideline).

5 Background (2) Recent emphasis on early detection and intervention services. After an acute episode there are often problems such as: social exclusion fewer opportunities to return to work or study problems forming new relationships Most people recover, although some have persisting difficulties or remain vulnerable to future episodes. Carers, relatives and friends are important during assessment and delivery of effective treatments. NOTES FOR PRESENTERS: Key points to raise: Schizophrenia is commonly associated with a number of other conditions, such as depression, anxiety, post-traumatic stress disorder, personality disorder and substance misuse. There has been emphasis on early detection and intervention and a focus on long-term recovery and promoting people’s choices about their management. Not everyone will accept help from statutory services. In the longer term, most people find ways to manage acute problems, and compensate for remaining difficulties. After an acute episode, there are often problems such as social exclusion, fewer opportunities to return to work or study, and problems forming new relationships. Carers, relatives and friends of people with schizophrenia are important in the process of assessment and engagement and in the long-term successful delivery of effective treatments. This guideline uses the term carer to apply to all people who have regular close contact with the person with schizophrenia, including family members, friends and guardians. Additional information: There is some evidence that early involvement in a progressive therapeutic programme incorporating social and psychological interventions as well as medication might be an important factor in realising long-term gains.(Harrison et al. 2001; Linszen et al. 2001; de Haan et al. 2003). Research has also suggested that delayed access to mental health services in early schizophrenia – often referred to as the duration of untreated psychosis – is associated with slower or less complete recovery, and increased risk of relapse and poorer outcome in subsequent years (Harrigan et al. 2003; Bottlender et al. 2003) (see the Disorder section of the full guideline).

6 Scope Treatment and management of schizophrenia and related disorders.
Adults with an established diagnosis (with onset before age 60). Does not address the specific treatment of people under 18, except those receiving treatment and support from early intervention services. NOTES FOR PRESENTERS: Key points to raise: Related disorders include schizoaffective disorder, schizophreniform disorder and delusional disorder. The guideline assumes that prescribers will use a drug’s summary of product characteristics (SPC) to inform their decisions for individual patients.

7 Access and engagement (1)
Healthcare professionals should ensure competence in: Working with people from diverse ethnic and cultural backgrounds: - Assessment skills - Using explanatory models of illness Addressing cultural and ethnic differences: - In treatment expectations and adherence - In beliefs regarding biological, social and family influences on the causes of abnormal mental states NOTES FOR PRESENTERS: Recommendation in full: Healthcare professionals working with people with schizophrenia should ensure they are competent in: assessment skills for people from diverse ethnic and cultural backgrounds using explanatory models of illness for people from diverse ethnic and cultural backgrounds explaining the causes of schizophrenia and treatment options addressing cultural and ethnic differences in treatment expectations and adherence addressing cultural and ethnic differences in beliefs regarding biological, social and family influences on the causes of abnormal mental states negotiating skills for working with families of people with schizophrenia conflict management and conflict resolution. [ ] Related recommendations: When working with people with schizophrenia and their carers: avoid using clinical language, or keep it to a minimum ensure that comprehensive written information is available in the appropriate language and in audio format if possible provide and work proficiently with interpreters where needed offer a list of local education providers who can provide English language teaching for people who have difficulties speaking and understanding English. [ ] Healthcare professionals inexperienced in working with people with schizophrenia from diverse ethnic and cultural backgrounds should seek advice and supervision from healthcare professionals who are experienced in working transculturally. [ ] Mental health services should work with local voluntary BME groups to jointly ensure that culturally appropriate psychological and psychosocial treatment, consistent with this guideline and delivered by competent practitioners, is provided to people from diverse ethnic and cultural backgrounds. [ ]

8 Access and engagement (2)
Healthcare professionals should ensure competence in: Explaining the causes of schizophrenia and treatment options Negotiating skills for working with families of people with schizophrenia Conflict management and conflict resolution NOTES FOR PRESENTERS: Recommendation in full: Healthcare professionals working with people with schizophrenia should ensure they are competent in: assessment skills for people from diverse ethnic and cultural backgrounds using explanatory models of illness for people from diverse ethnic and cultural backgrounds explaining the causes of schizophrenia and treatment options addressing cultural and ethnic differences in treatment expectations and adherence addressing cultural and ethnic differences in beliefs regarding biological, social and family influences on the causes of abnormal mental states negotiating skills for working with families of people with schizophrenia conflict management and conflict resolution. [ ] Related recommendations: When working with people with schizophrenia and their carers: avoid using clinical language, or keep it to a minimum ensure that comprehensive written information is available in the appropriate language and in audio format if possible provide and work proficiently with interpreters where needed offer a list of local education providers who can provide English language teaching for people who have difficulties speaking and understanding English. [ ] Healthcare professionals inexperienced in working with people with schizophrenia from diverse ethnic and cultural backgrounds should seek advice and supervision from healthcare professionals who are experienced in working transculturally. [ ] Mental health services should work with local voluntary BME groups to jointly ensure that culturally appropriate psychological and psychosocial treatment, consistent with this guideline and delivered by competent practitioners, is provided to people from diverse ethnic and cultural backgrounds. [ ]

9 Access and engagement (3)
Mental health services should work in partnership with local stakeholders (including those representing BME groups) to enable access to local employment and educational opportunities. Work with agencies, such as Jobcentre Plus, disability employment advisers and non-statutory providers should be sensitive to the person’s needs and skill level. NOTES FOR PRESENTERS: Recommendation in full: Mental health services should work in partnership with local stakeholders, including those representing black and minority ethnic (BME) groups, to enable people with mental health problems, including schizophrenia, to access local employment and educational opportunities. This should be sensitive to the person’s needs and skill level and is likely to involve working with agencies such as Jobcentre Plus, disability employment advisers and non-statutory providers. [ ] Related recommendations: Supported employment programmes should be provided for those people with schizophrenia who wish to return to work or gain employment. However, they should not be the only work-related activity offered when individuals are unable to work or are unsuccessful in their attempts to find employment. [ ] Routinely record the daytime activities of people with schizophrenia in their care plans, including occupational outcomes. [ ]

10 Access and engagement (4)
Identify a lead healthcare professional to monitor and review: access to and engagement with psychological interventions decisions to offer psychological interventions equality of access across different ethnic groups. NOTES FOR PRESENTERS: Recommendation in full: Healthcare teams working with people with schizophrenia should identify a lead healthcare professional within the team whose responsibility is to monitor and review: access to and engagement with psychological interventions decisions to offer psychological interventions and equality of access across different ethnic groups. [ ] Related recommendations: When providing psychological interventions, routinely and systematically monitor a range of outcomes across relevant areas, including service user satisfaction and, if appropriate, carer satisfaction. [ ] Healthcare professionals providing psychological interventions should: have an appropriate level of competence in delivering the intervention to people with schizophrenia be regularly supervised during psychological therapy by a competent therapist and supervisor. [ ] Trusts should provide access to training that equips healthcare professionals with the competencies required to deliver the psychological therapy interventions recommended in this guideline. [ ] When psychological treatments, including arts therapies, are started in the acute phase (including in inpatient settings), the full course should be continued after discharge without unnecessary interruption. [ ]

11 Primary care and physical health
GPs and other primary healthcare professionals should: - Monitor physical health at least once a year Focus on cardiovascular disease risk monitoring People with schizophrenia are at higher risk of cardiovascular disease than the general population A copy of the results should be: Sent to the care coordinator and/or psychiatrist Put in the secondary care notes NOTES FOR PRESENTERS: Recommendation in full: GPs and other primary healthcare professionals should monitor the physical health of people with schizophrenia at least once a year. Focus on cardiovascular disease risk monitoring as described in 'Lipid modification' (NICE clinical guideline 67) but bear in mind that people with schizophrenia are at higher risk of cardiovascular disease than the general population. A copy of the results should be sent to the care coordinator and/or psychiatrist, and put in the secondary care notes. [ ] Related recommendations: Develop and use practice case registers to monitor the physical and mental health of people with schizophrenia in primary care. [ ] People with schizophrenia at increased risk of developing cardiovascular disease and/or diabetes (for example, with elevated blood pressure, raised lipid levels, smokers, increased waist measurement) should be identified at the earliest opportunity. Their care should be managed using the appropriate NICE guidance for prevention of these conditions. [ ] Treat people with schizophrenia who have diabetes and/or cardiovascular disease in primary care according to the appropriate NICE guidance10. [ ] Healthcare professionals in secondary care should ensure, as part of the CPA, that people with schizophrenia receive physical healthcare from primary care as described in recommendations – [ ] When a person with an established diagnosis of schizophrenia presents with a suspected relapse (for example, with increased psychotic symptoms or a significant increase in the use of alcohol or other substances), primary healthcare professionals should refer to the crisis section of the care plan. Consider referral to the key clinician or care coordinator identified in the crisis plan. [ ] For a person with schizophrenia being cared for in primary care, consider referral to secondary care again if there is: poor response to treatment, non-adherence to medication, intolerable side effects from medication, comorbid substance misuse, risk to self or others. [ ] When re-referring people with schizophrenia to mental health services, take account of service user and carer requests, especially for: review of the side effects of existing treatments psychological treatments or other interventions. [ ] When a person with schizophrenia is planning to move to the catchment area of a different NHS trust, a meeting should be arranged between the services involved and the service user to agree a transition plan before transfer. The person’s current care plan should be sent to the new secondary care and primary care providers. [ ] See ‘Lipid modification’ (NICE clinical guideline 67), ‘Type 1 diabetes’ (NICE clinical guideline 15), ‘Type 2 diabetes’ (NICE clinical guideline 66). Further guidance about treating cardiovascular disease and diabetes is available from

12 Psychological interventions
Offer cognitive behavioural therapy (CBT) to all people with schizophrenia. Offer family intervention to all families who live with or are in close contact with the service user. Both can be started either during the acute phase or later, including in inpatient settings. NOTES FOR PRESENTERS: Key points to raise: CBT should be delivered as described in recommendation [ ] below Family intervention should be delivered as described in recommendation [ ] below Recommendation in full: Offer cognitive behavioural therapy (CBT) to all people with schizophrenia. This can be started either during the acute phase or later, including in inpatient settings. [ ] Offer family intervention to all families of people with schizophrenia who live with or are in close contact with the service user. This can be started either during the acute phase or later, including in inpatient settings. [ ] Related recommendations: Follow a treatment manual so that: people can establish links between their thoughts, feelings or actions and their current or past symptoms, and/or functioning re-evaluation of people’s perceptions, beliefs or reasoning relates to the target symptoms. Include at least one of the following components: people monitoring their own thoughts, feelings or behaviours with respect to their symptoms or recurrence of symptoms promoting alternative ways of coping with the target symptom reducing distress improving functioning. [ ] Family intervention Include the service user where practical. Include at least 10 planned sessions over a period of 3 months to 1 year. Take into account preference for single-family intervention rather than multi-family group intervention. Take into account the relationship between the main carer and the service user. Have a specific supportive, educational or treatment function. Include negotiated problem solving or crisis management work. Treatment manuals that have evidence for their efficacy from clinical trials are preferred. [ ] Additional information: The conclusions drawn in the previous guideline regarding the efficacy of CBT have been supported by the updated systematic review. The data for the reduction in rehospitalisation rates and duration of admission remains significant even when removing non-UK and pre-National Service Framework for Mental Health (Department of Health, 1999) papers in a sensitivity analysis, suggesting these findings may be particularly robust within the current clinical context. (taken from the section Cognitive Behavioural Therapy from the full guideline).

13 Pharmacological interventions
For people with newly diagnosed schizophrenia offer oral antipsychotic medication Provide information and discuss the benefits and side-effect profile of each drug offered with the service user The choice of particular antipsychotic drug should be made by the service user and healthcare professional together, considering: – the relative potential to cause extrapyramidal, metabolic and other side effects – the views of the carer (if the service user agrees). NOTES FOR PRESENTERS: Recommendation in full: For people with newly diagnosed schizophrenia, offer oral antipsychotic medication. Provide information and discuss the benefits and side-effect profile of each drug with the service user. The choice of drug should be made by the service user and healthcare professional together, considering: the relative potential of individual antipsychotic drugs to cause extrapyramidal side effects (including akathisia), metabolic side effects (including weight gain) and other side effects (including unpleasant subjective experiences) the views of the carer if the service user agrees. [ ] Related recommendation: Treatment with antipsychotic medication should be considered an explicit individual therapeutic trial. Include the following. Record the indications and expected benefits and risks of oral antipsychotic medication, and the expected time for a change in symptoms and appearance of side effects. At the start of treatment give a dose at the lower end of the licensed range and slowly titrate upwards within the dose range given in the British National Formulary (BNF) or SPC. Justify and record reasons for dosages outside the range given in the BNF or SPC. Monitor and record the following regularly and systematically throughout treatment, but especially during titration: efficacy, including changes in symptom and behaviour side effects of treatment, taking into account overlap between certain side effects and clinical features of schizophrenia, for example the overlap between akathisia and agitation or anxiety adherence physical health. Record the rationale for continuing, changing or stopping medication, and the effects of such changes. Carry out a trial of the medication at optimum dosage for 4‑6 weeks. [ ] Additional information: In the previous guideline (which incorporated the recommendations from the NICE technology appraisal of second-generation antipsychotics, NICE, 2002), in some situations, Second Generation Antipsychotics were recommended as first-line treatment, primarily because they were thought to carry a lower potential risk of EPS. However, evidence from the updated systematic reviews of clinical evidence, particularly with regard to other adverse effects such as metabolic disturbance, together with new evidence from effectiveness (pragmatic) trials suggest that choosing the most appropriate drug and formulation for an individual may be more important than the drug group. (from the section Pharmacological interventions in the treatment and management of schizophrenia from the full guideline).

14 Pharmacological interventions
Do not initiate regular combined antipsychotic medication except for short periods, for example, when changing medication. NOTES FOR PRESENTERS: Related recommendations: Discuss any non-prescribed therapies the service user wishes to use (including complementary therapies) with the service user, and their carer if appropriate. Discuss the safety and efficacy of the therapies, and possible interference with the therapeutic effects of prescribed medication and psychological treatments. [ ] Discuss the use of alcohol, tobacco, prescription and non-prescription medication and illicit drugs with the service user, and carer if appropriate. Discuss their possible interference with the therapeutic effects of prescribed medication and psychological treatments. [ ] ‘As required’ (p.r.n.) prescriptions of antipsychotic medication should be made as described in recommendation Review clinical indications, frequency of administration, therapeutic benefits and side effects each week or as appropriate. Check whether ‘p.r.n.’ prescriptions have led to a dosage above the maximum specified in the BNF or SPC. [ ] Do not use a loading dose of antipsychotic medication (often referred to as ‘rapid neuroleptisation’). [ ] If prescribing chlorpromazine, warn of its potential to cause skin photosensitivity. Advise using sunscreen if necessary. [ ]

15 Interventions for people with schizophrenia whose illness has not responded adequately to treatment
Review the diagnosis. Check adherence to antipsychotic medication, and the dose and duration. Review engagement with and use of psychological treatments. If family intervention undertaken suggest CBT. If CBT undertaken suggest family intervention for people in close contact with their families. Consider other causes of non-response. NOTES FOR PRESENTERS: Key points to raise: CBT should be delivered as described in recommendation [ ] Family intervention should be delivered as described in recommendation [ ] Recommendation in full: For people with schizophrenia whose illness has not responded adequately to pharmacological or psychological treatment: review the diagnosis establish that there has been adherence to antipsychotic medication, prescribed at an adequate dose and for the correct duration review engagement with and use of psychological treatments and ensure that these have been offered according to this guideline. If family intervention has been undertaken suggest CBT; if CBT has been undertaken suggest family intervention for people in close contact with their families consider other causes of non-response, such as comorbid substance misuse (including alcohol), the concurrent use of other prescribed medicines or physical illness. [ ]

16 Interventions for people with schizophrenia whose illness has not responded adequately to treatment
Offer clozapine to people with schizophrenia whose illness has not responded adequately to treatment despite the sequential use of adequate doses of at least two different antipsychotic drugs. At least one of the drugs should be a non-clozapine second-generation antipsychotic. NOTES FOR PRESENTERS: Recommendation in full: as on slide. [ ] Related recommendation: For people with schizophrenia whose illness has not responded adequately to clozapine at an optimised dose, healthcare professionals should consider recommendation (including measuring therapeutic drug levels) before adding a second antipsychotic to augment treatment with clozapine. An adequate trial of such an augmentation may need to be up to 8–10 weeks. Choose a drug that does not compound the common side effects of clozapine. [ ]

17 Arts therapy Consider offering arts therapies to all people with schizophrenia, particularly for the alleviation of negative symptoms. This can be started either during the acute phase or later, including in inpatient settings. NOTES FOR PRESENTERS: Key point to raise: This is not a key priority for implementation, but a significant addition to NICE guidance in this field. Related recommendation: Arts therapies should be provided by a Health Professions Council (HPC) registered arts therapist, with previous experience of working with people with schizophrenia. The intervention should be provided in groups unless difficulties with acceptability and access and engagement indicate otherwise. Arts therapies should combine psychotherapeutic techniques with activity aimed at promoting creative expression, which is often unstructured and led by the service user. Aims of arts therapies should include: enabling people with schizophrenia to experience themselves differently and to develop new ways of relating to others helping people to express themselves and to organise their experience into a satisfying aesthetic form helping people to accept and understand feelings that may have emerged during the creative process (including, in some cases, how they came to have these feelings) at a pace suited to the person. [ ]

18 Costs and savings The guideline on schizophrenia is unlikely to result in a significant change in resource use in the NHS. However, recommendations in the following areas may result in additional costs/savings depending on local circumstances: race, culture and ethnicity pharmacological interventions psychological and psychosocial interventions. NOTES FOR PRESENTERS: NICE has found that implementing this guideline is unlikely to result in any significant changes in resource use, based on national assumptions. However, different areas may vary from the national average and it is important to look at the recommendations most likely to have a resource impact to make sure that local practice matches the national average - Race, culture and ethnicity recommendations. The costs will mostly relate to training existing healthcare professionals, although there will be some lower recurrent costs for training new staff. Pharmacological interventions are a key cost factor that is hard to determine because there is a significant element of choice. It is hoped that the cost of providing CBT will be outweighed by the cost savings resulting from improved adherence. Healthcare professionals have raised concerns over resource levels for CBT, family intervention and arts therapy. There will be significant costs associated with training therapists to carry out psychological treatments. Additional information: Evidence suggests that limited resources and a shortage of trained psychological therapists are important factors in restricting implementation of these recommendations. According to figures produced by the Healthcare Commission in 2006 only 46% of people who had been diagnosed with schizophrenia were offered CBT. The cost of providing inpatient care for a person with schizophrenia for one night is approximately £256 (based on figures provided by the Department of Health). As CBT costs approximately £1072 per person, the average length of stay (currently 111 nights) would need to be reduced by approximately 4% for CBT to be cost neutral. A Healthcare Commission survey revealed that only 53% of people who were eligible for family intervention had received it in the 12 months preceding March For this therapy to be cost neutral, the average inpatient stay would need to be reduced by approximately 10%. Arts therapies have been shown to be effective when carried out individually or in groups. (Taken from NICE costing statement.)

19 Discussion How do current staff competencies match those described in the recommendations? How are cultural aspects addressed? How well do current links with stakeholder organisations support employment and educational links? How can the quality and number of annual health checks carried out on people with schizophrenia be improved? How do we measure access to, uptake of and outcomes for CBT and family-based interventions? How well does current prescribing practice match the new recommendations? NOTES FOR PRESENTERS: These questions are suggestions that have been developed to help provide a prompt for a discussion at the end of your presentation – please edit and adapt these to suit your local situation.

20 Find out more Visit www.nice.org.uk/CG82 for: the guideline
the quick reference guide ‘Understanding NICE guidance’ costing template and costing statement audit support guide to resources NOTES FOR PRESENTERS: You can download the guidance documents from the NICE website. The NICE guideline – all the recommendations. A quick reference guide – a summary of the recommendations for healthcare professionals. ‘Understanding NICE guidance’ – information for service users and carers. The full guideline – all the recommendations, details of how they were developed, and reviews of the evidence they were based on. For printed copies of the quick reference guide or ‘Understanding NICE guidance’, phone NICE publications on or and quote reference numbers N1823 (quick reference guide) and/or N1824 (‘Understanding NICE guidance’). NICE has developed tools to help organisations implement this guideline, which can be found on the NICE website. Costing template – allows you to estimate the local costs and savings involved. Costing statement – details of the likely costs and savings when the cost impact of the guideline is not considered to be significant. Audit support – for monitoring local practice. Guide to resources – provides sources of patient information on the disorder and medication as well as evidence for arts therapy and mental health competencies.


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