1. Biotechnology VC Funding, Vaccines, Technology

2. What is Biotechnology? Biotech: refers to the use of living organisms or their products to modify human health and the human environment. Recombinant DNA Technology has made this all possible

3. Applications  Healthcare  Gene therapy, pharma, genetic testing, Sequencing of Human Genome  Green Biotech  Genetic engineering to produce environmentally detrimental products through a renewable feedstock  Bioinformatics  Using computational models to enhance understanding of DNA in all organisms

4. Viruses Viruses mutate very fast, our immune system cannot keep up to detect, develop immune response and defend our healthy cells H1N1, has an enzyme called Reverse Transcriptase that makes errors naturally, mutates quickly as it spreads

7. Vaccines Polio and small pox were eliminated using vaccines Target of this technology is to eradicate: Influenza virus causes 35,000 USA deaths annually HIV Hepatitis B Virus Human T Cell Lymphocyte Virus

8. Example of Startup MolecularBreeding™ Technology DNA Shuffling leads to high throughput screening to rapidly identify antigens with the potential to provide protection against various diseases Big benefit is technology is universal to all viruses, bigger piece of market pie Market Annual Vaccine Market $25.8B annualy Growing at a rate of 31.8% annually

10. Benefits of this technology Most viruses are live attenuated viruses, meaning you are get a piece of a live virus, develop immunity and thus a defense against the virus for life; or a killed pathogen However, these methods have not worked for vaccine development with HIV, Hep B, H1N1, etc Our screening: robust, fast, rapid screening of potential vaccines; we use Viruses abilities of “stealth mode” to deliver the vaccine

11. Potential of Biotech DNA Vaccine technology can keep up with viral mutations, and prevent a pandemic Green Technology Reduce dependency on foreign petroleum Field is really only 20 years old, nascent technologies need to be refined but potential is great