1. The Structural Heart Disease Program your partners for advanced interventional cardiology Structural Heart Disease is a new branch of cardiology involving catheter based treatment of heart conditions that used to be treatable only with open heart surgery. Yet, even with advancements in today’s technology, not all patients with the same condition are good candidates for the same procedure. The University of Miami Miller School of Medicine and UHealth – University of Miami Health System provide an array of advanced services to the South Florida community and beyond. Our multidisciplinary Structural Heart Disease program is a resource to you and your patients dealing with challenging cardiac issues. University of Miami Hospital has 5 dedicated suites for interventional cardiology, including a unique suite designed to combine minimally- invasive percutaneous cardiovascular interventions with cardiovascular surgical procedures. Our cardiac imaging program includes cardiac CT, Cardiac MR, 3D Transthoracic and Transesophageal echocardiography, and it is fully integrated with our advanced structural heart disease program. Yet our team is only half of the equation. We are only at our best with the partnership of the skilled and compassionate physicians who refer their patients to us for interventional care. Our Structural Cardiology Team Interventional Cardiology Carlos Alfonso, M.D. Mauricio Cohen, M.D. Eddy De Marchena, M.D. Alan Heldman, M.D. Claudia Martinez, M.D. Mauro Moscucci, M.D. William O’Neill, M.D. Juan Zambrano, M.D. Cardiac Surgery Didier De Cannier, M.D. Marco Ricci, M.D. Don Williams, M.D. Cardiac Imaging Martin Bilsker, M.D. Joel Fishman, M.D. Robert Hendel, M.D. Maureen Lowery, M.D. Melissa Tracy, M.D. Howard Willens, M.D. To access any of our services, or for urgent inquiries, call our Physician to Physician Cardiovascular Access Line (UMax) 1-305-243-8300. Figure: Percutaneous treatment of a mitral valve paravalvular leak. Using the transseptal approach, a glide wire has been advanced into the left ventricle across the mitral valve leak in preparation for closure.

2. Interventional Services at UHealth For the treatment of cardiovascular conditions and structural heart disease: Diagnostic catheterization (coronary and peripheral) Complex angioplasty and stenting (coronary and peripheral) Carotid artery stenting Alcohol septal ablation for hypertrophic cardiomyopathy Percutaneous closure of atrial septal defects and PFO Percutaneous closure of ventricular septal defects (post myocardial infarction) Mitral valvuloplasty Aortic valvuloplasty Percuataneous aortic valve replacement (investigational) Percuatenous closure of paravalvular leaks Direct left ventricular apical puncture Transseptal cardiac catheterization Atrial septostomy for pulmonary hypertension Tandem heart supported or Impella supported high risk PCI Stem cell therapy for ischemic and non ischemic cardiomyopathy (investigational) To access any of our services, or for urgent inquiries, call our Physician to Physician Cardiovascular Access Line (UMax) 1-305-243-8300. Catheter-based treatment of structural heart disease is rapidly evolving. As technology advances, and new treatment options become available, one thing remains the same: the need for interventionalists, cardiac surgeons, general cardiologists and cardiac imaging specialists to collaborate closely on the care of each patient. The University of Miami Cardiovascular Program offers one of the nation’s most advanced programs for the diagnosis and percutaneous treatment of a full spectrum of structural heart conditions. Unique procedures we offer are available at few other centers in the nation, and offer opportunities for patients with advanced or complex disease to be treated. CATH LAB EXPERTS We offer our referring partners this pledge: -To provide timely, thoughtful consultations with our lead physicians on any case in which you are considering an interventional solution on an as needed and expedited basis. - To provide you with direct access to our structural heart disease program for formal or informal consultations. - To expedite the scheduling of your patients for interventional procedures at UHealth. - To expedite any tests or treatments needed for your patients, and to minimize patients travel time and re-visits. - To provide you with a full report of their care and outcomes in an extremely timely manner. - To provide an integrated and multidisciplinary approach to complex conditions such as hypertrophic cardiomyopathy, valvular heart disease, paravalvular leaks or cryptogenic stroke. Respectfully yours, Mauro Moscucci, M.D., M.B.A. Clinical Vice Chairman, Department of Medicine Chief, Cardiovascular Division