1. THURSDAY 2-12-15 LEARNING OBJECTIVE: WHAT ARE GENES? ENTRY TASK: WHAT DO YOU KNOW ABOUT: GENES DNA GENE THERAPY CANCER CYSTIC FIBROSIS PROTEIN HOW ARE THESE TERMS RELATED?

2. PLAN OF THE DAY INTRO TO GENETICS DNA AND CELL DIVISION UNIT 10 YEARS OF GENOME RESEARCH AND GENETIC DISEASES HTTPS://WWW.YOUTUBE.COM/WATCH?V=FGQ-XOYORWY 60:00

3. FRIDAY 2-13-15 LEARNING OBJECTIVE: STRUCTURE OF THE DNA MOLECULE ENTRY TASK: WHAT ARE THE FOUR BASES PRESENT IN THE DNA MOLECULE? LOOK AT PAGE 345 – FIGURE 12-5 AND TRANSFER THE DIAGRAM TO YOUR JOURNAL 1 ST ELODEA 4 TH HEARTS

4. PLAN OF THE DAY CHECK YOUR TEST RESULTS FOR CHAPS. 8 & 9 INTRO TO GENETICS DNA AND CELL DIVISION UNIT 10 YEARS OF GENOME RESEARCH AND GENETIC DISEASES HTTPS://WWW.YOUTUBE.COM/WATCH?V=FGQ-XOYORWY 60:00

5. TUESDAY 2-17-15 LEARNING OBJECTIVE: STRUCTURE OF THE DNA MOLECULE ENTRY TASK: WHAT WOULD BE THE MATCHING DNA STRAND THAT WOULD PAIR WITH THIS SEQUENCE OF BASES? A T A A T T G C G G A T T C

6. PLAN OF THE DAY DNA STRUCTURE AND FUNCTION CRASH COURSE ON DNA BRAINSTORM WITH PARTNER ON WHAT MATERIALS TO BRING FOR DNA MODEL

7. HTTPS://WWW.YOUTUBE.COM/WATCH?V=RW7XU7DURG4 53:00 HTTPS://WWW.YOUTUBE.COM/WATCH?V=RW7XU7DURG4 HTTPS://WWW.GOOGLE.COM/?GWS_RD=SSL#Q=DNA+CRASH+COURSE 13:00 HTTPS://WWW.GOOGLE.COM/?GWS_RD=SSL#Q=DNA+CRASH+COURSE HTTPS://WWW.YOUTUBE.COM/WATCH?V=5QSRMEIWSUC 8:00 REPLICATION WITH THE AMOEBA SISTERS

8.  The basic unit of the DNA molecule is called: NUCLEOTIDE

9. A NUCLEOTIDE in DNA has three parts:  A ring-shaped sugar called deoxyribose  A phosphate group  A nitrogenous base (single or double ring of carbon and nitrogen atoms)

10. Nucleotide monomers join together by covalent bonds between the sugar of one nucleotide and the phosphate of the next, forming a sugar- phosphate backbone.

11. Nitrogenous Bases

12. The bases pair up (A-T & G-C) forming the DOUBLE HELIX first described by Watson and Crick

13. Watson, Crick and Franklin

14. Various ways to model DNA structure http://www.umass.edu/molvis/tutorials/dna/dnapairs.htm manipulate DNAhttp://www.umass.edu/molvis/tutorials/dna/dnapairs.htm

15. WEDNESDAY 2-18-15 LEARNING OBJECTIVE: STRUCTURE OF THE DNA MOLECULE ENTRY TASK: DNA GOES THROUGH THE PROCESS OF REPLICATION (DUPLICATION) IN OUR CELLS. WHY DO YOU THINK THIS PROCESS IS NECESSARY?

16. PLAN OF THE DAY WORK WITH YOURSELF OR WITH YOUR PARTNER TO BUILD YOUR 3D DNA MODEL IF YOU DID NOT BRING MATERIALS FOR YOUR OWN MODEL, GET THE HANDOUT TO DO THE FLAT DNA MODEL IF FINISHED, READ AND TAKE NOTES OF SECTION 12.3 (PP 350-351) IN YOUR NOTEBOOK (DUE FRIDAY 19)

17. DNA MODELS PAPER MODELS HTTP://WWW.GOV.MB.CA/CONSERVATION/SUSTAIN/DNADONE.PDF HTTP://WWW.MYSCIENCEBOX.ORG/BOOK/EXPORT/HTML/347 HTTP://WWW.ALDER.K12.OH.US/USERFILES/251/CLASSES/2831/DNAMODELPARTSFORYOURPRESE NTATION.PDF HTTP://WWW.ALDER.K12.OH.US/USERFILES/251/CLASSES/2831/DNAMODELPARTSFORYOURPRESE NTATION.PDF ORIGAMI DNA HTTPS://WWW.YOUTUBE.COM/WATCH?V=LEJF0F1JTUQ HTTP://WWW.DNAI.ORG/TEACHERGUIDE/GUIDE.HTML HTTP://WWW.DNAI.ORG/TEACHERGUIDE/PDF/ORI_COLOR.PDF HTTP://WWW.DNAI.ORG/TEACHERGUIDE/PDF/ORIGAMI_INST.PDF HTTP://WWW.DNAI.ORG/TEACHERGUIDE/PDF/ORI_BW.PDF

18. THURSDAY 2-19-15 LEARNING OBJECTIVE: STRUCTURE OF THE DNA MOLECULE ENTRY TASK: GET YOUR DNA MODELS READY. IN 20 MINUTES WE WILL START PRESENTATIONS

19. PLAN OF THE DAY FINISH LAST TOUCHES OF YOUR DNA MODEL AND PRESENT IT TO YOUR CLASSMATES IF FINISHED, READ AND TAKE NOTES OF SECTION 12.3 (PP 350-351) IN YOUR NOTEBOOK (DUE FRIDAY 20)

20. FRIDAY 2-20-15 LEARNING OBJECTIVE: DNA REPLICATION PROCESS ENTRY TASK: NAME TWO OF THE ENZYMES INVOLVED IN THE DNA REPLICATION PROCESS AND THEIR FUNCTION

21. PLAN OF THE DAY LAST PRESENTATIONS OF DNA MODEL REPLICATION NOTES REPLICATION PRACTICE WITH WHITE BOARD CREATING A DNA REPLICATION SKIT WITH THE ENTIRE CLASS

22. Why does DNA need to be replicated? Growth – new cells - reproduction How does this process happen?

23. REPLICATION IN 3 STEPS  DNA replication results in two new DNA molecules, each containing one new strand (yellow) and one original strand (blue)

24.  Weak bonds  Hydrogen bonds  Comes apart easily  Comes together easily

25. Overview of DNA replication  DNA separates  Complementary nucleotides are linked along separated strands

26. initiate  Initiator protein guides unzipper protein (helicase) to correct position on DNA

27. untwister  Untwister (topoisomerase) unwinds the DNA double helix in advance of the unzipper

28. Unzipper separates DNA strands, breaking weak bonds between the nucleotides unzip

29. assemble Builders (polymerases) assemble new DNA strand by joining nucleotides to their matching complements on the exposed strands

30. straightners  Straighteners (single-strand DNA binding proteins) keep single strand of DNA from tangling

31. Phosphate provides energy Phosphate bond energy from the new nucleotides is used to make the new bonds

32. Leading vs. Lagging strand  Leading (top) strand is built continuously as the builder follows behind the unzipper, but the Lagging (lower) strand builds in the opposite direction

33. Lagging strand  Lagging (lower) builder makes a loop with the DNA strand and builds in opposite direction

34. Lagging strand  Built in small sections  Sections linked by enzyme ligase

35. Repairs of DNA  Erasers (Repair Nuclease): find poorly matched or damaged nucleotides and cut them out

36. Repairs of DNA  Builders (Polymerase): fill gaps using other DNA strand as a guide

37. Repairs of DNA  Stitchers (Ligase): uses ATP to restore continuity of backbone of repaired strand

38. Big picture of DNA replication

39. Replication review

40. REPLICATION IN 3 STEPS  DNA replication results in two DNA molecules, each with one new strand (yellow) and one old strand (blue)

41. DNA replication animations  http://www.youtube.com/watch?v=4jtmO ZaIvS0 http://www.youtube.com/watch?v=4jtmO ZaIvS0 http://www.youtube.com/watch?v=4jtmO ZaIvS0  http://www.youtube.com/watch?v=gW3qZ F9cLIA http://www.youtube.com/watch?v=gW3qZ F9cLIA http://www.youtube.com/watch?v=gW3qZ F9cLIA  http://www.youtube.com/watch?v=oNW_ ykH3AvA http://www.youtube.com/watch?v=oNW_ ykH3AvA http://www.youtube.com/watch?v=oNW_ ykH3AvA  http://www.youtube.com/watch?v=hC_8y 8fNkCw http://www.youtube.com/watch?v=hC_8y 8fNkCw http://www.youtube.com/watch?v=hC_8y 8fNkCw

42. TED talk – DNA replication – Chromosomes- malaria  http://www.youtube.com/watch?v=dMPX u6GF18M http://www.youtube.com/watch?v=dMPX u6GF18M http://www.youtube.com/watch?v=dMPX u6GF18M  Timing of replication article:  http://hms.harvard.edu/news/marching- our-own-sequences http://hms.harvard.edu/news/marching- our-own-sequences http://hms.harvard.edu/news/marching- our-own-sequences