1. Biomedical optics - 10380 brought to you by the BIOP center A joint initiative between the Technical University of Denmark, Risø National Laboratory and Danish Industry

2. P. E. Andersen - 9/9/2015 Optics and Fluid Dynamics Department RISØ Bio-optics course  Welcome  Introduction  Practical notes regarding the course  The BIOP center

3. P. E. Andersen - 9/9/2015 Optics and Fluid Dynamics Department RISØ Biomedical optics  The term biomedical optics could be ”defined” as – irradiation of tissue or biological material by light source (eg. laser) causing response; »photo-thermal reaction, »optical (reflectance/transmittance), »photo-chemical reaction, »fluorescence, »...  The response may be used to – diagnose (sensing, imaging, concentration, etc.) – treatment (photodynamics therapy) – surgery and manipulation (eg. tweezers)

4. P. E. Andersen - 9/9/2015 Optics and Fluid Dynamics Department RISØ Biomedical optics  Why do we need to learn about – light sources and laser systems, – light propagation in tissue, – spectroscopy, – signal and image processing?  Because – these are the ’fundamentals’ you need to understand or describe the device, application or system you work with or wish to develop.

5. P. E. Andersen - 9/9/2015 Optics and Fluid Dynamics Department RISØ Example 1: Choose light source

6. P. E. Andersen - 9/9/2015 Optics and Fluid Dynamics Department RISØ Example 1: Choose light source  Light propagation (Monte Carlo simulation) Incident light Ballistic component “Snake” component Diffuse reflectance Absorption Diffuse transmittance

7. P. E. Andersen - 9/9/2015 Optics and Fluid Dynamics Department RISØ Example 1: Choose light source

8. P. E. Andersen - 9/9/2015 Optics and Fluid Dynamics Department RISØ Example 2: describe system Superluminescent diode (SLD) Detector Fiber-optic beamsplitter Tissue Scanning reference mirror Computer AmplifierBandpass filter

9. P. E. Andersen - 9/9/2015 Optics and Fluid Dynamics Department RISØ Example 2: Build the system

10. P. E. Andersen - 9/9/2015 Optics and Fluid Dynamics Department RISØ Example 2: Signal

11. P. E. Andersen - 9/9/2015 Optics and Fluid Dynamics Department RISØ Example 2: Modeling the OCT signal L. Thrane et al., J. Opt. Soc Am. A 17, 484 – 490 (2000).

12. P. E. Andersen - 9/9/2015 Optics and Fluid Dynamics Department RISØ Example 2: OCT image  OCT as optical diagnostic tool in ophthalmology

13. P. E. Andersen - 9/9/2015 Optics and Fluid Dynamics Department RISØ Example 2: OCT image  3D rendering of data

14. P. E. Andersen - 9/9/2015 Optics and Fluid Dynamics Department RISØ Practical notes  Course overview – divided into four major areas, – experts in various fields will teach, – outside lecturers and visits.  Course material – copies (free) of book chapters and/or articles – why? – because the topic is diverse you would need several text books = too expensive!  Assignments during course – hands-on and home work assignments.

15. P. E. Andersen - 9/9/2015 Optics and Fluid Dynamics Department RISØ Practical notes  Exam – the last ¼ of the course is allocated for individual/group assignments, – topic is chosen starting April, – small report; »should be handed in on May 15, 2002, – presentation of report – another group appointed ’opponents’ »defense will take place on June 7, 2002.

16. P. E. Andersen - 9/9/2015 Optics and Fluid Dynamics Department RISØ Practical notes  Course coordinator – Peter E. Andersen, Risø »e-mail: peter.andersen@risoe.dk, »tel: 46 77 45 55.  Messages and updates are published at – www.biop.dk.