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OSCE Answer 02/2015 TMH AED 1. Question 1 M/69 Known history of HT, IHD, PVD Sudden onset of constant low back pain BP 162/85mmHg P 78/min 2.

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Presentation on theme: "OSCE Answer 02/2015 TMH AED 1. Question 1 M/69 Known history of HT, IHD, PVD Sudden onset of constant low back pain BP 162/85mmHg P 78/min 2."— Presentation transcript:

1 OSCE Answer 02/2015 TMH AED 1

2 Question 1 M/69 Known history of HT, IHD, PVD Sudden onset of constant low back pain BP 162/85mmHg P 78/min 2

3 Question 1 Suggest 5 differential diagnosis of acute low back pain – Mechanical spinal disease – Non-mechanical spinal disease – Visceral disease 3

4 Mechanical Spinal Disease Lumbar strain Degenerative spine Spondylolisthesis Spinal stenosis Prolapsed intervertebral disc Osteoporosis Fracture or facet joint dislocation 4

5 Non-Mechanical Spinal Disease Neoplasia – Multiple myeloma – Bone metastasis – Lymphoma and leukemia – Spinal cord tumour Infection – Osteomyelitis – Septic discitis – Epidural abscess Inflammatory arthritis – Ankylosing spondylitis – Psoriatic spondylitis – Reiter disease Paget disease 5

6 Visceral Disease Pelvic – Chronic pelvic inflammatory disease – endometriosis Renal – Nephrolithiasis – Pyelonephritis – Perinephric abscess Gastrointestinal – Acute pancreatitis – Acute cholecystitis Abdominal aortic aneurysm Psoas abscess 6

7 Red Flag Symptoms 7

8 Question 1 Bedside abdominal USG was performed 8

9 Question 1 What’s the sonographic diagnosis? – 7cm in diameter abdominal aortic aneurysm with concentric hyperechoic lesion signifying thrombus 9

10 Question 1 How to measure the size of the lesion? – Outer to Outer wall – Longitudinal view – Perpendicular to the long axis of aorta 10

11 Question 1 How to classify the type of the lesion using ultrasound? – Identify the origin of the SMA, 2cm below should be the origin of renal arteries – Classify according to the location of the aortic aneurysm Suprarenal Juxtarenal Infrarenal (Ultrasound Clin 2 (2007) 437–453) 11

12 Question 1 State the microbe that is most commonly associated with this condition? – A study in southern Taiwan from 1996 to 2006 on mycotic aneurysm Salmonella (34.6%) Klebsiella (11.5%) Staphylococcus aureus (11.5%) (J Microbiol Immunol Infect 2008;41(4): 318-324) 12

13 Question 2 F/40 Good past health Sudden onset of right sided weakness 1 hour before BP 180/93 mmHg P 104/min GCS 15/15 13

14 Question 2 Urgent CT brain was performed 14

15 Question 2 Described the CT finding – Loss of insular ribbon sign – A loss of definition of the gray-white interface in the lateral margin of the insular cortex (Radiology. 1990;176(3):801) 15

16 Question 2 Suggest 3 more hyperacute stroke CT signs – Hypodensity of basal ganglia 16

17 Question 2 Dense MCA sign 17

18 Question 2 Cortical Sulcal Effacement 18

19 Question 2 Outline subsequent management plan for this patient – Stabilization, history taking and physical examination – Baseline investigations like blood tests, ECG, CXR – Consult neurologist for assessment – Stroke management – Reperfusion therapy and anti-platelet agent Emerg Med Clin North Am. 2012 Aug;30(3):713-44 19

20 Stroke Management Fluid – Hypovolemia  reduce cerebral perfusion – Hypervolemia  cerebral edema – Look for SIADH with hyponatremia Glucose – Hypoglycemia  stroke mimics – Hyperglycemia  poor functional outcome – (Stroke. 2001;32(10):2426) 20

21 Stroke Management Head position – Lying flat would increase mean flow velocity of cerebral artery by 20% in one study (Neurology. 2005;64(8):1354) – Prop up 30° in patients with Raised intracranial pressure Risk of aspirations Cardiopulmonary disease or oxygen desaturation 21

22 Stroke Management Blood pressure control – Blood pressure control within 7 – 10 days post stroke leads to increase 30 days mortality (The Lancet. 22/10/2014 open access) (http://dx.doi.org/10.1016/S0140-6736(14)61121-1)http://dx.doi.org/10.1016/S0140-6736(14)61121-1 – Goals of blood pressure control Thrombolytic therapy: SBP < 185mmHg, DBP < 110mmHg No thrombolytic therapy: SBP <220mmHg, DBP < 120mmHg 22

23 Reperfusion Therapy Intravenous alteplase (tPA) within 4.5 hours from onset Intra-arterial alteplase (tPA) within 6 hours from onset Mechanical thrombolysis 23

24 Antiplatelet treatment Aspirin 160 to 320mg daily within 48 hours would decrease recurrent of stroke within 14 days and death within 28 days (International Stroke Trial (IST) and Chinese Acute Stroke Trial (CAST)) ?Dual antiplatelet treatment with aspirin and clopidogrel (300mg loading, then 75mg daily) for high risk patient (ABCD 2 score ≥ 4) (CHANCE trial) 24

25 Question 2 State 3 etiologies for young onset stroke – Cardiac Congenital heart disease Endocarditis, cardiomyopathy, prosthetic valve replacement – Haematologic sickle cell disease Prothrombolic conditions like antiphospholipid syndrome, protein C deficiency, protein S deficiency etc 25

26 Question 2 State 3 etiologies for young onset stroke – Vasculopathy Moyamoya disease (primary or secondary) Dissection Vasculitis – Substance abuse 26

27 Question 2 Cerebral angiogram was performed after stabilization 27

28 Question 2 Describe the finding – Puff of smoke appearance – Due to collateral vasculature What is the diagnosis? – Moyamoya disease 28

29 Moyamoya Disease Bilateral stenosis or occlusion of vessels around circle of Willis with prominent collateral circulation Moyamoya is Japanese, meaning hazy like a puff of smoke in the air Can lead to both ischemic and haemorrhagic stroke 29

30 Question 3 F/56 Good past health Vehicle-pedestrian collision with left knee injury BP 153/79mmHg P 95/min 30

31 Question 3 Left knee X-ray was taken 31

32 Question 3 Describe the X-ray finding – Fracture over lateral tibial plateau of the left knee – No depression What is the classification of the above condition? – Schatzker classification Which type this patient belonged to? – Type I 32

33 Schatzker Classification 33

34 Question 3 What is the mechanism of the injury? – Valgus force with axial loading 34

35 Question 3 Name 4 potential complications – Early complications Compartment syndrome Vascular injury (popliteal artery) Nerve injury (peroneal nerve) Infection Deep vein thrombosis 35

36 Question 3 Name 4 potential complications – Late complications Knee stiffness Knee instability Osteoarthritis Malunion, nonunion Angular deformity Late collapse 36

37 Question 4 M/72 History of DM, HT, SSS on pacemaker Sudden onset of severe chest pain for 3 hours, only partially relieved by TNG BP 164/88 mmHg P 62/min 37

38 Question 4 ECG was performed 38

39 Question 4 Describe the ECG findings – Widen QRS complex with heart rate 60/min (pacemaker beat) – ST elevation in I, aVL, V4-V6 – Reciprocal ST depression in III, aVF 39

40 Question 4 State an ECG criteria for assistance of diagnosis – Sgarbossa criteria What is the diagnosis? – Acute anteriolateral ST elevation myocardial infarction 40

41 Sgarbossa Criteria 41

42 Modified Sgarbossa Criteria 42

43 Sgarbossa Criteria ST elevation ≥1 mm in a lead with a positive QRS complex (ie: concordance) - 5 points ST depression ≥1 mm in lead V1, V2, or V3 - 3 points ST elevation ≥5 mm in a lead with a negative (discordant) QRS complex - 2 points ≥3 points, sensitivity 36%, specificity 90% (NEJM 334(8):481-487) 43

44 Modified Sgarbossa Criteria at least one lead with concordant STE (Sgarbossa criterion 1) or at least one lead of V1-V3 with concordant ST depression (Sgarbossa criterion 2) or proportionally excessively discordant ST elevation in V1-V4, as defined by an ST/S ratio of equal to or more than 0.20 and at least 2 mm of STE. (this replaces Sgarbossa criterion 3 which uses an absolute of 5mm) Sensitivity 91%, Specificity 90% (Annals of Emergency Medicine 60 (6): 766–776.) 44

45 Question 4 Outline the management in AED – Recognize emergency condition and manage in resuscitation room with resuscitation equipments standby – Monitoring devices – Set up large bore IV access, blood tests, CXR – Consult cardiologist for assessment – MONA – Reperfusion therapy – Antithrombotic therapy and antiplatelet therapy 45

46 Primary PCI Door to balloon time – 90 minutes in PCI capable hospital – 120 minutes in non-PCI capable hospital Patients presented more than 12 hours, with cardiogenic shock, electrical instability or persistent ischemic symptoms (2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction) 46

47 Thrombolytic therapy Symptoms within 12 hours with primary PCI not available within 120 minutes Door to needle time less than 30 minutes Facilitated PCI is not recommended Rescue PCI if failed fibrinolysis (2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction) 47

48 Thrombolytic therapy First generation fibrinolytic agents (eg streptokinase) indiscriminately induce activation of circulating plasminogen and clot-associated plasminogen Second generation fibrinolytic agents (eg t-PA) preferentially activate plasminogen in the fibrin domain Second generation fibrinolytic agents improve 24 hours, 30 days and 1 year mortality rate in GUSTO trial (Circulation. Oct 10 2000;102(15):1761-5.) 48

49 Antithrombotic therapy Enoxaparin 0.5mg/kg significant reduced clinical ischemic outcome compared with unfractionated heparin in STEMI patient undergoing primary PCI (ATOLL trial. Lancet. Aug 20 2011;378(9792):693-703.) 49

50 Antiplatelet agents Aspirin should be given immediately Adding clopidogrel 300mg (CLARITY-TIMI 28) is safe and effective Increase clopidogrel to 600mg in patient with STEMI prior to primary PCI was associated with a smaller infarct size (ARMYDA-6 MI) (J Am Coll Cardiol. Oct 4 2011;58(15):1592-9.) 50

51 Question 5 M/62 Repeated vomiting for 1 day, with mild epigastric pain after an alcohol binge First vomited out undigested food and then mild blood streak 51

52 Question 5 BP 123/59 mmHg P 84/min Abdominal examination was unremarkable. Per rectal examination noted brownish stool. CXR was normal 52

53 Question 5 Name 3 clinical prediction rules/scores in upper gastrointestinal bleeding to risk stratification – Glasgow-Blatchford bleeding score – Rockall score – AIMS65 53

54 Question 5 He asked if his condition could be managed without hospital admission State which score is the most relevant in this scenario? What cut-off and associated clinical implication for the score? – Glasgow Blatchford bleeding score – Score 6 or more has more than 50% risk of needing an intervention 54

55 Glasgow Blatchford Bleeding Score 55 Lancet. 2000;356(9238):1318.

56 Rockall Score 56 Lancet. 1996;347(9009):1138.

57 AIMS65 (Gastrointest Endosc. 2011;74(6):1215.) 57

58 Question 5 More history was taken and he had known alcoholic with alcoholic liver cirrhosis Blood tests result: – Hb 13.4 g/dL – Urea 7.8 mmol/L 58

59 Question 5 How would you management this patient? – GBS 4 – Admit to EMW for observation NPO IV fluid Type and screen, clotting profile 59

60 Question 5 He developed gross haematemesis during his stay in AED BP 96/49 mmHg P 106/min 60

61 Question 5 How would you manage this patient in addition to the management you ordered before? – Manage in resuscitation room – Nasogastric tube insertion, suction with airway protection – IV fluid resuscitation and hemodynamic resuscitation – Consult surgeon for urgent OGD – IV somatostatin analog, vasopressin – Balloon tamponade 61

62 Question 6 M/69 History of HT, DM, old CVA Decrease general condition for 1 month 62

63 Question 6 63

64 Question 6 Describe the CT finding – Hydrocephalus 64

65 Ventriculomegaly vs hydrocephalus Enlargement of the recesses of the third ventricle Dilation of the temporal horns of the lateral ventricle Interstitial edema of the periventricular tissues (seen on MRI) Effacement of the cortical sulci 65

66 Ventriculomegaly vs hydrocephalus 66

67 Question 6 What further investigations would you proceed? – MRI – Lumbar puncture 67

68 Question 6 If the opening pressure of the lumbar puncture is 12 cm H 2 O What is the condition called? – Normal Pressure Hydrocephalus What is the classic triad of this condition? – Gait instability (magnetic gait) – Cognitive impairment – Urinary incontinence 68

69 Question 6 What is the definitive treatment? – VP shunt 69

70 70


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