1. ANATOMY AND FUNCTION OF HUMAN BODY (be health and safe in your workplace) dr. NURUL HIDAYATI, M.Sc Department of Anatomy-Histology Faculty of Medicine UNIVERSITAS BRAWIJAYA

3. Demands of work duties and environment Safety and Health issue at work

4. Learning Objectives  Understand roles of anatomy structure and function of human body in a working area in term of safety and healthy at work  Be able to optimize the role of anatomy and function of human body to improve someone’s performance at work  For specific reason, applying knowledge of anatomy and function of human body in relevant field of areas as the professional practice

5. Complex structures and function to live

6. From simple to complex …

7. Levels of Organization  Chemical  Cellular  Tissue  Organs  System Level  Organismic Level

8. Levels of Structural Organization  Chemical Level - atomic and molecular level  Cellular level - smallest living unit of the body  Tissue level Group of cells and the materials surrounding them that work together on one task 4 basic tissue types: epithelium, muscle, connective tissue, and nerve

9.  Organ level - consists of two or more types of primary tissues that function together to perform a particular function Example: Stomach ○ Inside of stomach lined with epithelial tissue ○ Wall of stomach contains smooth muscle ○ Nervous tissue in stomach controls muscle contraction and gland secretion ○ Connective tissue binds all the above tissues together  System - collection of related organs with a common function, sometimes an organ is part of more than one system  Organismic level - one living individual Levels of Structural Organization

10. HUMAN BODYSYSTEMSHUMAN BODYSYSTEMS

11. Anatomy structures of human body  nervous system  respiratory system  excretory system  muscular system  endocrine system  lymphatic (immune) system  integumentary system  digestive system  skeletal system  circulatory system  reproductive system

12. Body Systems

15. Basic mechanism to survive / live  “The body’s automatic tendency to maintain a relatively constant internal environment within a dynamic state of equilibrium when outside conditions change Internal conditions change/vary within narrow limits. Body systems must respond to changes quickly and in the right way. Homeostasis is essential for survival and function of all cells Homeo – unchanging Statis – standing Homeostasis Keeping the Balance

16. What can go wrong with homeostasis? Copyright © Houghton Mifflin Harcourt Publishing Company A problem in one body system may cause problems in other body systems. Lack of food and the presence of toxins or pathogens may disrupt the proper functioning of body systems. Problems with cells, tissues, or organs can cause problems in the body. If cells cannot get energy or necessities, they cannot work properly. When the body cannot maintain homeostasis, it is easier for pathogens to invade the body

17.  Control systems are grouped into two classes Intrinsic controls ○ Local controls that are inherent in an organ Extrinsic controls ○ Regulatory mechanisms initiated outside an organ ○ Accomplished by nervous and endocrine systems Two mechanisms Autoregulation – when a tissue, organ or organ system responds automatically Extrinsic regulation – when response results from the action of one of the two organ systems that control or adjust the function of many other systems simultaneously Homeostatic Control Systems

18.  Feedforward - term used for responses made in anticipation of a change  Feedback - refers to responses made after change has been detected Homeostatic Control Systems  Negative feedback loop original stimulus reversed most feedback systems in the body are negative used for conditions that need frequent adjustment  Positive feedback loop original stimulus intensified seen during normal childbirth

19. Negative Feedback Loop  Receptor - structures that monitor  a controlled condition and  detect changes  Control center – determines next action  Effector receives directions from the control center produces a response that restores the controlled condition

20. Negative Feedback Loop

21. NEGATIVE FEEDBACKNEGATIVE FEEDBACK LOOPLOOP

22. Homeostasis – Negative Feedback Loop  Blood glucose concentrations rise after a sugary meal (the stimulus), the hormone insulin is released and it speeds up the transport of glucose out of the blood and into selected tissues (the response), so blood glucose concentrations decrease (thus decreasing the original stimulus).

23. Homeostasis of Blood Pressure  Baroreceptors in walls of blood vessels detect an increase in BP  Brain receives input and signals blood vessels and heart  Blood vessels dilate, HR decreases  BP decreases

24. Positive Feedback during Childbirth  Stretch receptors in walls of uterus send signals to the brain  Brain induces release of hormone (oxytocin) into bloodstream  Uterine smooth muscle contracts more forcefully  More stretch, more hormone, more contraction etc.  Cycle ends with birth of the baby & decrease in stretch

25. Role of Body Systems in Homeostasis

26. THANK YOU …..