1. Page 1 NCMD Bringing Together North Carolina’s Medical Device Community SBIR Seminar Introduction to NCMD March 24, 2005 Andrew DiMeo North Carolina Medical Device Organization Andrew@NCMedicalDevice.org www.NCMedicalDevice.org Phone: 919.606.1337 Fax: 919.573.9423

2. Page 2 Summary NCMD mission and vision Why focus on medical devices? North Carolina’s assets Defining the NCMD space Target Cluster Services Board of Directors Event Outlook

3. Page 3 NCMD Mission & Vision Mission: Position North Carolina’s medical device and diagnostic industry as a research, development, and production world leader Vision: Enhance North Carolina’s medical device and diagnostic industry through public policy, networking, training, and business development

4. Page 4 Why focus on medical devices? NC consistently in top 3-5 states for Biotech, yet not positioned in the medical device market $94 billion market growing at 7% per year Creates high paying jobs – both in research for areas like RTP and in manufacturing in the more rural parts of the state According to economic census data, there are currently 15,000 medical device related jobs in NC

5. Page 5 Why? (continued) Harvard Professor Michael Porter Medical devices are an “under-realized opportunity” for North Carolina RTI International “Identify and task an organization to serve a professional catalyst role by inventorying medical device and diagnostics capabilities and needs, conducting networking events, and addressing industry needs.”

6. Page 6 North Carolina’s Assets 246 medical equipment manufacturing facilities Commitment to employer training in Bioscience by investing in programs at many community colleges 4 world class medical schools (UNC, ECU, Duke, & Wake Forest) 4 Biomedical Engineering programs (UNC, NCSU, Duke, & Wake Forest) 1 of only 27 US veterinary schools (NCSU) Leading biology experts and growing Medical Physics program (UNCC) Growing Biomedical Engineering group (ECU) Triangle region second only to Boston in NIH funding for medical schools Medical Equipment Manufacturing Facilities Map prepared by the NC Dept. of Commerce Div. of Policy, Research & Strategic Planning Source: Harris InfoSource referenced August 2004 Legend Manufacturing Locations

7. Page 7 Defining the NCMD space: …intended to affect the structure or any function of the body… Pharmaceutical/Drugs –Manufactured by a chemical process Biotechnology/Biologics –Manufactured by a biological process Medical Devices –Mechanical, Electrical, etc. –Neither chemical nor biological mfg. process Combination Products –Two or Three of the above combined/kitted –Forecast to be a $9.5 billion market by 2009 Diagnostic Products Medical Information Systems

8. Page 8 Target Cluster Research/Develop/Manufacture Medical: –Devices, combo products, diagnostics, and info systems –Platform technology for above product types Suppliers and Service Companies –Including Contract Manufacturers Hospitals and Clinics –Individual Clinicians –Individual Departments (such as Sports Medicine) Academic Institutions –Individual Researchers –Departments (such as Biomedical Engineering Programs) Any interested individual or organization

9. Page 9 NCMD Services Host Training programs & forums with expert speakers discussing relevant topics and to promote networking Assemble a statewide device & diagnostic directory Advocate for policy to create best environment for existing & new companies, and for recruitment to NC Hold an annual conference for the state, bringing together and showcasing NC’s medical device industry Maintain a job board to assist in searches for NC device & diagnostic companies Maximize intra-state business among existing companies to help create more jobs

10. Page 10 Board of Directors Rich West, Adigy CEO - NCMD Chairman and executive committee member Peyton Anderson, Affinergy CEO - NCMD Chair-elect & executive committee member Sam Taylor, Exec. VP, NCBIO - NCMD Finance Chair & executive committee member Jeff Clark, Managing General Partner, The Aurora Funds Monica Doss, President, CED - NCMD executive committee member Geff Erickson, Ph.D., Sr. Associate, A.M. Pappas & Associates - NCMD executive committee member Richard Kindberg, Sr. VP & General Manager, Medical Products Div., Teleflex Medical Garheng Kong, M.D., Ph.D., Partner, Intersouth Partners Dayn McBee, SunTech Medical CEO Neil C. Olson, D.V.M., Ph.D., NC State University - NCMD executive committee member Dan Pelak, President and CEO, Closure Medical Bob Singletary, Exec. Director, Research & Technology, WakeMed Health and Hospitals Sam Tetlow, Principal, Research Triangle Ventures Rob Tyler, Partner, Hutchison+Mason PLLC - NCMD executive committee member

11. Page 11 Event Outlook 5/16/05 – NCMD Regulatory Forum –Patricia Love, Associate Director, FDA, Office of Combination Products –Heather Rosecrans, Director of the Premarket Notification (510(k)) Staff, FDA, Office of Device Evaluation Aug/Sept ’05 – NC MedTech Outlook (Charlotte?) November ’05 – ½ day device day conference February ’06 – NCMD Meet new companies and venture forum (Winston-Salem?)