1. Molecular Machine (Jacobson) Group MIT – January 2005 Avogadro Scale Engineering

2. Simple molecules <1nm IBM PowerPC 750 TM Microprocessor 7.56mm×8.799mm 6.35×10 6 transistors Semiconductor Nanocrystal ~1 nm 10 -10 10 -5 10 -9 10 -7 10 -6 10 -8 10 -4 10 -3 10 -2 m Circuit design Copper wiring width 0.1  m red blood cell ~5  m (SEM) DNA proteins nm bacteria 1  m Nanotube Transistor (Dekker) 10 12 bits/cm 2 (1Tbit/cm 2 ) Molecular Machines (Jacobson) Group SOI transistor width 0.12  m diatom 30  m

3. Fabricational Complexity F fab = ln (W) / [ a 3  fab E fab ] F fab = ln (M)  -1 / [ a 3  fab E fab ] Total Complexity Complexity Per Unit Volume Complexity Per Unit Time*Energy Complexity Per unit Cost

4. Chip Fab Example CMOS Processor Fabrication Time: 3 Weeks 7x24 Processing Moore’s Law: 2X – 18 Months Can We Use The Complexity Metric To Do Better?

5. www.panasonic.com DVD6 Disk Replication 3 second replication time. ~ 3 cents per disk 18.8 GB Data Pit Size: 0.25 um

6. All-Printed All-Inorganic Transistors Solution Based Inorganic Semiconductor Chemistry Ridley et al., Science, 286, 746 (1999) Science 297,416 (2000) Molecular Machines (Jacobson) Group - MIT www.media.mit.edu/molecular NanoTectonics

7. All Printed-All Inorganic 3D nm Building Blocks – Seconds Per Layer Ridley et. Al, Science, 286, 746 (1999) Bulthaup et. Al. APL 79(10): 1525 (2001) Molecular Machines (Jacobson) Group Embossed Chips 200 nm

8. Bulthaup et. Al. APL 79(10): 1525 (2001) Molecular Machines (Jacobson) Group Multilayer Liquid Assembly All Printed-All Inorganic Logic Elements Department of Mechanical Engineering NANOTECTONICS

9. 20  m Liquid Embossed MEMS Department of Mechanical Engineering Molecular Machines (Jacobson) Group Eric Wilhelm, PhD Mech E.

10. What Does The Future Look Like? Parts List http://lucy.itc.virginia.edu/~wmr5a/molecular_vrml/ATPase/ATPase.htm Motors Sensors http://www.mpi-bremen.de/magneto/research/ Inorganic Electronic Structure RF Biology Logic

11. Gene Level Error Removal

12. http://www.thetech.org/exhibits_events/traveling/robotzoo/about/images/grasshopper.gif 1.Air inlets 2.Crushers 3.Ganglion 4.Multiple Visual sensors 5.Muscles 6.Pincers 7.Sensory receptors 8.Stridulatory pegs 9.Wings Molecular Machines Group-MIT Faculty Joseph Jacobson Research Scientists and Post Docs Peter Carr (Whitehead) Kie-Moon Sung Graduate Students Brian Chow Saul Griffith David Kong David Mosley (Chemistry) Chris Emig