2. Mammalian Circulation: Components and Control AP Biology Unit 6

3. Mammalian Heart 4 chambered heart (2 atria, 2 ventricles) Valves = flaps that keep chambers of the heart closed at the right time Valves are needed to build pressure in heart and prevent back-flow of blood. Right sideLeft side

4. Atrioventricular (AV) Valves Located between the atria and ventricles Tricuspid Valve –Between the right atrium and right ventricle –3 flaps Bicuspid (Mitral) valve –Between the left atrium and left ventricle –2 flaps

5. Semilunar valves located at two exits for the heart Between the right ventricle and the pulmonary artery (to lungs) Between the left ventricle and the aorta (to the body)

6. Pathway of Blood Do you remember the pathway of blood through the body and the heart? Use these terms: Right Atrium, Left Atrium, Right Ventricle, Left Ventricle, Pulmonary Artery, Pulmonary Vein, Aorta, Lung Capillaries, Capillaries in Top or Bottom of Body, Anterior / Posterior Vena Cava Start where the blood first leaves the heart to go to the body

7. Pathway of blood Aorta  arteries  capillaries in body  veins  vena cava  right atrium  right ventricle  pulmonary artery  lung capillaries  pulmonary vein  left atrium  left ventricle  aorta

8. Questions… Where does the blood have the highest O 2 concentration? –Just after leaving lungs (where it picked up O 2 ) Where does the blood have the highest CO 2 concentration? –Just before getting to the lungs (hasn’t dropped off the CO 2 waste yet)

9. Heartbeat The heart beat is controlled by electrical signals generated in specific cells in the heart = self excitation Sinoatrial (SA) node = a group of specialized cells that initiates the heartbeat –Also called the pacemaker of the heart –generates electrical impulses that cause both atria to contract

10. Heartbeat Atrioventricular (AV) node –When it receives the signals from the SA node, it transfers the signals to the Bundle of His Bundle of His spreads the signal to the Purkinje fibers in the ventricles  both ventricles contract

11. Blood Flow through Vessels Arteries (and arterioles) –Thick, muscular walls –Walls also contain collagen and elastic fibers (make them stretchable) –Can be constricted or dilated

12. Blood Flow through Vessels Veins (and venules) –Thinner walls –one-way valves to prevent blood from flowing backwards –Blood in veins is moved by the contractions of skeletal muscles around them (“milking”) – low pressure

13. Blood Flow through Vessels Capillaries –Thin walls (usually one cell layer thick) –Permeable to water, ions, other small molecules –Blood flows slowly through them (red blood cells often have to travel single file) –Every cell in the body is close to at least 1 capillary

14. Capillaries Capillaries exchange materials between the blood and the interstitial fluid Blood pressure and osmotic pressure drive the movement of molecules into and out of capillaries –Blood pressure forces water and solutes out (on the artery side) –Osmotic pressure (due to the proteins left in the capillaries) causes fluid to flow back into the capillaries by osmosis

15. Question… How does the structure of each type of vessel support its function? –Arteries– thick walls can withstand pressure from heart pumping blood –Veins- valves help prevent backflow since the heart is too far away to provide forward pressure –Capillaries- very thin walls allow for easy exchange with the interstitial fluid

16. Blood Pressure Blood pressure = the force being applied to the blood vessel walls (from blood). 2 phases of the cardiac cycle –Systole = when the heart muscle is contracting –Diastole = when the heart muscle is relaxed (between contractions)

17. Blood Pressure Systolic Pressure = pressure in arteries when heart contracts Diastolic Pressure = pressure in arteries between contractions

18. Question… Giraffes need higher blood pressure. Why? Since they are taller, they need more pressure to get the blood all the way to the top of their bodies

19. Components of blood Plasma (liquid) –Water, nutrients, proteins, ions, etc. Cellular Components –Red blood cells (carry oxygen) –White blood cells (immune function) –Platelets (clotting)

20. Differentiation of Blood Cells Blood cells (RBC, WBC and platelets) all develop from stem cells in the red bone marrow. Erythropoietin (EPO) is a hormone that promotes the production of erythrocytes (RBC) –Synthesized in the kidneys

21. Question… When the body is not receiving enough O 2, what will happen to EPO levels? –They increase to create more RBC to carry O 2

22. Control of Circulation Heart rate is controlled by –Nerve impulses sent to SA and AV Nodes Parasympathetic division- slows heartbeat down Sympathetic division – speeds up heart beat –Hormones (adrenaline/epinephrine) –Body temperature –Oxygen requirements due to exercise

23. Control of circulation The opening of sphincters leading to capillary beds (group of capillaries) is controlled by –Nerve impulses –Hormones Allows blood to be directed to specific parts of the body under stressful conditions

24. Control of Circulation The Lymphatic System also plays a role in controlling circulation –Lymph = fluid in lymphatic system (like interstitial fluid, high in water and other nutrients) –Fluids flow out and into lymph capillaries via blood pressure and osmotic pressure –Maintains blood volume so blood pressure can remain constant

25. Question… How is the lymph connected to the digestive system? –Lacteals are lymph vessels in the villi that absorb some nutrients from the small intestines.

26. Blood clotting Platelets begin the clotting reaction –damage in the blood vessel wall exposed collagen fibers –Platelets stick the collagen release substances to make other platelets sticky Clotting factors = released by platelets to activate enzymes needed for clotting

27. Blood Clotting STEPS: 1.Platelets adhere to the damaged region and become sticky  release clotting factors 2.Clotting factors cause Prothrombin (inactive) to become Thrombin (active) 3.Thrombin causes Fibrinogen (plasma protein) to become fibrin (active form) 4.Fibrin forms threads that help seal the damaged area up

28. Cardiovascular Disease Atherosclerosis = narrowing of arteries due to plaque build up –plaque deposits as a result damage to the vessel lining –Plaque deposits narrow the pathway for blood to flow –If the plaque is ruptured it will also cause clotting to occur– blocks pathway of blood

29. Cardiovascular Disease Atherosclerosis can lead to heart attack or stroke –Heart attack – blockage in the arteries that supply the heart with blood –Stroke = blockage in an artery in the brain Relationship between high blood pressure and heart disease? –High blood pressure will damage the lining of the arteries  causes plaque to deposit in the damaged areas.

30. Heart Disease and Cholesterol Cholesterol travels in the blood (plasma); carried by lipoproteins Low Density Lipoproteins (LDLs) are associated with cholesterol deposits in arteries = “bad” cholesterol High Density Lipoproteins (HDLs) appear to reduce cholesterol deposition = “good” cholesterol What seems to matter is the ratio of HDL to LDLs in your blood

31. Cholesterol and lifestyle choices While there is a genetic component to cholesterol levels, lifestyle choices also influence it –Exercise increases HDL levels, lowers LDL levels –Smoking increases LDL and lowers HDL levels