1. Liver Pathology, CASE 2 53 year-old with chronic alcohol and drug abuse who has been in numerous rehabilitation facilities in the past now presents with abdominal pain after a 3-week alcoholic “binge.”

2. Identify the organ Describe the gross findings. Diagnosis?

3. The autopsy specimen of the liver reveals cirrhosis. The liver is discolored yellow-brown and has a nodular surface.

4. Identify the organ Describe the gross findings. Diagnosis?

5. Cirrhosis (alcoholic) The liver reveals fatty changes and nodularity.

6. Cirrhosis The surface of the liver is nodular.

7. Identify the organ Describe the gross findings. Diagnosis?

8. Cirrhosis (alcoholic) A cut section of the liver reveals micronodules and fatty change.

9. Describe the lower power histologic findings Bands of fibrosis Producing pseudolobules

10. Describe the findings in this trichrome stain (stains collagen blue) A - Pseudolobule B - Fibrosis

11. Mallory bodies Steatosis Few neutrophils with hepatocyte necrosis

12. Diagnosis? Acute alcoholic hepatitis superimposed on alcoholic cirrhosis.