1. Table 4.1.1: Stock and Flow of Liver Transplantation, 1993-2006 Year93949596*979899000102**03040506 New transplant patients11813328351051658 Deaths00341041251443 Re-transplant00000000000000 Lost to follow up00000001010110 Functioning graft at 31 st December 127161719232427313445 50 * 1 patient who was alive until 05/12/1997 is recorded died with missing date of death ** 1 patient who had transplanted in 2003 is recorded as death with missing date of death

2. Figure 4.1.1: Stock and Flow of Liver Transplantation, 1993-2006 Number of patients (n) Year 0 5 10 15 20 25 30 35 40 45 50 New patients Alive at 31st Dec 1993 1994199519961997199819992000200120022003200420052006

3. Table 4.1.2: Distribution of Patients by Place of Transplant, 1993-2006 Year9394959697989900010203040506TOTAL No. NoNo. Local008101183592145874 Overseas1103210001320014 TOTAL1181332835105165888

4. Table 4.1.3: Distribution of Patients by Centres for Liver Transplantation, 1993-2006 Year9394959697989900010203040506TOTAL CentreNo. Subang Jaya Medical Centre 00810118356270051 Hospital Selayang0000000003075823 Australia100310000000005 National University Hospital, Singapore 000011000000002 Kings College Hospital, UK 010000000000001 Tianjin, China000000000011002 Asian Centre for Liver Disease & Transplantation, Singapore 0000000001210* 4 TOTAL1181332835105165888 * Data was not reported

5. Table 4.1.4: Distribution of Transplant Recipients by Follow-up Centres, 2006 CentreNo.% Number of patient with functioning graft at 31 st December 200650100 Kuala Lumpur Hospital24 SJMC27*54 Selayang Hospital1734 Singapore1*2 UMMC36 *Follow-up data was not reported

6. Table 4.2.1: Distribution of Patients by Gender, 1993-2006 Year9394959697989900010203040506TOTAL GenderNo. Male00652131275102650 Female1128115233063238 TOTAL1181332835105165888

7. Figure 4.2.1: Distribution of Patients by Gender, 1993-2006 Number of patients (n) Year 0 2 4 6 8 10 Male Female 1993 1994 1995 1996 199719981999 2000200120022003200420052006

8. Table 4.2.2: Distribution of Patients by Ethnic Group, 1993-2006 Year9394959697989900010203040506TOTAL Ethnic groupNo. Malay01231041231113335 Chinese1068212236451344 Indian000201100000127 Others000000100100002 TOTAL1181332835105165888

9. Figure 4.2.2: Distribution of Patients by Ethnic Group, 1993-2006 Number of patients (n) Year 0 2 4 6 8 10 12 Malay Chinese Indian Others 19931994199519961997199819992000200120022003 2004 2005 2006

10. Table 4.2.3: Distribution of Patients by Age, 1993-2006 Year19931994199519961997199819992000200120022003200420052006TOTAL Age, yearsNo. <1000001000100002 1-411311315344292453 5-90031002014233120 10-14001100000001014 15-19000000100001002 20-39001000000100024 40-59000000000001001 >=60000000000011002 TOTAL1181332835105165888 Mean249421412618124 7 SD--94115127312231514 Median246221312473552 Minimum242213 months1114 months11123 months Maximum24301421152524737483974 * Age=date of transplant – date of birth

11. Table 4.2.4: Primary Diagnosis, 1993-2006 (N=88) Year 19931994199519961997199819992000200120022003200420052006TOTAL Primary DiagnosisNo. Biliary atresia117123172562104263 Metabolic liver disease001100000202006 Cholestatic liver disease000001010000103 Primary biliary cirrhosis000000000000000 Primary sclerosing cholangitis000000000000000 Autoimmune hepatitis000000100000001 Chronic hepatitis B000000000032005 Chronic hepatitis C000000000000000 Alcoholic liver disease000000000000000 Malignancies000000000121004 Acute liver failure000000000001034 Idiopathic / Cryptogenic000000000000000 Others000000000201148 *6 patients have more than one primary disease

12. Table 4.2.5: Indication for Transplantation, 1993-2006 (N=88) Year 19931994199519961997199819992000200120022003200420052006TOTAL Indication for TransplantationNo. Recurrent encephalopathy001000100100003 Uncontrolled bleeding varices0007104110020016 Intractable ascites000000000000000 Spontaneous bacterial peritonitis000000000000000 Poor liver function117113183593 4168 Malignancy000000000010001 Unacceptable quality of life000000000100102 Failure to thrive, growth retardation in paediatric patients 006103263572 3158 Others0000000000012811 No data000000000112004 *21 patients had 1 indication for transplantation, 63 had more than 1 indication for transplantation

13. Table 4.2.6: Recipient Blood Group, 1993-2006 (N=88) Year9394959697989900010203040506TOTAL Blood groupNo. A0120003013141420 B0012012011011313 AB000101000001104 O0025103335182134 No data1035200001320017 TOTAL1181332835105165888

14. Table 4.3.1: Distribution of Patients by Type of Donors, 1993-2006 (N=88) Year 19931994199519961997199819992000200120022003200420052006 TOTAL Type of TransplantNo. Cadaveric1003100001142417 Living related - Mother0152125222271133 Living related - Father0027102023011322 Living related - Son000000000011002 Living related - Brother000000000100001 Living related - emotionally000000000010001 Living unrelated0011001113030011 TOTAL1181332835105164887 * 1 patient is Living related - Other

15. Table 4.3.2: Immunosuppressive Drug Treatment at Transplantation, 1993-2006 (N=88) Year 19931994199519961997199819992000200120022003200420052006 TOTAL Immunosuppressive drugsNo. Steroids00250252551125852 Azathioprine0000000000045817 Cyclosporin A111200010000006 Tacrolimus (FK506)00372282595125868 Mycophenolate Mofetil (MMF) 000000000000000 Rapamycin000000000120003 Monoclonal / Polyclonal antibody 000000000000000 Anti IL2R Antibodies000000000000000 Others000000000000000 No data0043100001040013 TOTAL patients1181332835105165888 * 21 patients had 1 type of drug, 37 patients had 2 types, 17 patients had 3 types

16. Table 4.4.1: Patient Survival by Year of Transplant, 1993-2006 (N=88) Year of Transplant1993 - 19981999 - 2006 Interval (months)% SurvivalSE% SurvivalSE 1827835 6719706 12719706 SE=standard error

17. Figure 4.4.1: Patient Survival by Year of Transplant, 1993-2006

18. Table 4.4.2: Patient Survival by Gender, 1993-2006 (N=88) GenderMaleFemale Interval (months)% SurvivalSE% SurvivalSE 1825846 6716708 12716708 SE=standard error

19. Figure 4.4.2: Patient Survival by Gender, 1993-2006

20. Table 4.4.3: Patient Survival by Age Group, 1993-2006 (N=88) Age group0-9 years>=10 years Interval (months)% SurvivalSE% SurvivalSE 1815100- 66868910 126868910 SE=standard error

21. Figure 4.4.3: Patient Survival by Age Group, 1993-2006

22. Table 4.4.4: Distribution of Patient by Cause of Death, 1993-2006 (N=88) Year199519961997199819992000200120022003200420052006TOTAL Causes of deathNo. Graft failure0000010000203 Chronic graft rejection0000001000001 Intra-abdominal Bleeding0000000010001 Peritonitis0000000100001 CMV Pneumonia0000100000001 Decompensated liver cirrhosis0000000100001 Intracranial haemorrhage0100100000002 Malignancy0000000000101 Variceal bleed0010200000003 Pneumonia and respiratory failure0100000000001 Post transplant lymphoproliferative disease0000001000001 Sepsis0200000201139 Unknown3000000103007 TOTAL34104125144332 Note: 2 patients with no date of death