1. Cesar A. Hidalgo Center for Complex Network Research, University of Notre Dame / Northeastern University The Human Phenotypic Disease Network

2. Collaborators Nicholas Christakis Laurie Meneades Jason Block Dept. of Health Policy, Harvard Medical School Laszlo Barabasi Nicholas Blumm Deok-Sun Lee J Park Center for Network Science, Northeastern University Christine Teutsch Massachusetts General Hospital Harvard Medical School

3. Some Diseases are known to be related

4. ENPP1 HFCS SLS Ectonuclide Pyrophosphate Phosphodiesterase 1 High Fructose Corn Syrup Sedentary Life Style There are no single causes for each disease DiabetesObesity

5. Determining causes is labor and capital intensive

6. Disease 2Disease 1

7. Disease 2 Affect Same Individuals Significantly more than Random

8. C 12 P1P1 P2P2 N Building a Net

9. ~ 13039018 patients 58.3% females, 90.1% white 7.5% black ~ 32341348 records (hospitalizations) Up to 10 diagnosis (from ~950 cat (3digit) / ~14000 (5digit) )

12. Disease 2 Disease 1

14. CHF

16. CONCLUSIONS We introduced the concept of a phenotypic disease network. This network can be used to help explore life cycle strategies for drug companies and hospital design. This network can be used to perform comparative studies. Ultimately, the goal is to help determine disease ontology based on their comorbidity patterns

17. http://www.nd.edu/~chidalgo Or Google: CA Hidalgo http://www.nd.edu/~networks Or Google: CCNR