1. Diabetes Feasibility Presentation ODU Green Team 2008 6 March 2008 Adam Hamer – System Engineer Meredith Wilhelm – Support Manager Michele Majchrowski – Team Leader Francis Pruter – Quality/Process Mgr Eric Schultz – Development Mgr Derek Allen – Planning Manager

2. March 22, 2008 CS 410 Green Team - Diabetes 2 Outline Introduction Problem Statement  Characteristics Of Problem  Complications Process Flow Proposed Solution Market Analysis Competitors Risks Conclusion

3. March 22, 2008 CS 410 Green Team - Diabetes 3 Problem Statement Diabetics encounter lifelong challenges managing their disease.

4. March 22, 2008 CS 410 Green Team - Diabetes 4 Glucose (Blood Sugar) Testing MedlinePlus Medical Encyclopedia. http://www.nlm.nih.gov/medlineplus/ency/imagepages/18029.htmhttp://www.nlm.nih.gov/medlineplus/ency/imagepages/18029.htm

5. March 22, 2008 CS 410 Green Team - Diabetes 5 Problem Characteristics 1,500,000 new cases are discovered each year. 24,000,000 of Americans have some form of diabetes Diabetes cost the U.S. an estimated $174,000,000,000 last year alone. Insulin drug market will reach $30,000,000,000 by 2014 Only 250,000 diabetics use an insulin pump. American Diabetes Association. http://www.diabetes.org/diabetes-statistics.jsphttp://www.diabetes.org/diabetes-statistics.jsp

6. March 22, 2008 CS 410 Green Team - Diabetes 6 Acute Complications Hypoglycemia (Low Blood Sugar)‏  Irreversible brain death  Coma  Seizure Hyperglycemia (High Blood Sugar)‏  Death  Hyperosmolar coma  Shock

7. March 22, 2008 CS 410 Green Team - Diabetes 7 Chronic Complications Amputation Heart Disease Diabetic Nephropathy: Kidneys Diabetic Neuropathy: Nerves Diabetic Retinopathy: Eyes

8. March 22, 2008 CS 410 Green Team - Diabetes 8 Benefits of Stabilized Glucose Levels 54% decrease in kidney disease 60% decrease in nerve disease 76% decrease in eye disease Overall well-being Diabetes Care, volume 31, number 3 http://care.diabetesjournals.org/misc/econcosts.pdfhttp://care.diabetesjournals.org/misc/econcosts.pdf

9. March 22, 2008 CS 410 Green Team - Diabetes 9 Main Process Flow

10. March 22, 2008 CS 410 Green Team - Diabetes 10 Calculation Process

11. March 22, 2008 CS 410 Green Team - Diabetes 11 Insulin Administration Process

12. March 22, 2008 CS 410 Green Team - Diabetes 12 Monitor Result Process

13. March 22, 2008 CS 410 Green Team - Diabetes 13 Proposed Solution Insulin pump that utilizes diabetic management software that allows the user to review historical data that evaluates lifestyle trends.

14. March 22, 2008 CS 410 Green Team - Diabetes 14 Our solution will… Make calculating caloric intake easier Provide additional features that existing insulin pump PDAs lack Utilize formulas to learn reactions to meals Alert the user of possible ‘danger’ food Provide a searchable personal database of foods Recommend proper insulin dosage for meals based on past history  by meal chosen, caloric count, and/or activity level Show caloric patterns

15. March 22, 2008 CS 410 Green Team - Diabetes 15 Our solution will not… Cure diabetes Change existing insulin delivery methods Be affordable without insurance Be unbreakable

16. March 22, 2008 CS 410 Green Team - Diabetes 16 Advantages Of Solution Easier glucose level mangement Better understanding of what foods are safe Access to historical data  categorized into activity types

17. March 22, 2008 CS 410 Green Team - Diabetes 17 Disadvantages Of Solution More likely to try new foods not yet discovered as a danger food Expensive if insurance does not cover the device May reduce understanding of condition and calculations

18. March 22, 2008 CS 410 Green Team - Diabetes 18 Market Analysis Directed towards Type I Diabetics Over 400,000 insulin pump users world wide An annual growth of 9.5% diabetics that use insulin pump Predicted cost of solution is approximately five thousand dollars Average monthly cost for insulin and upkeep is four hundred and eighty dollars American Diabetes Association. http://www.diabetes.org/diabetes-statistics.jsphttp://www.diabetes.org/diabetes-statistics.jsp

19. March 22, 2008 CS 410 Green Team - Diabetes 19 Competitors XXXXXLarge Doses XXXXContinuous Glucose Monitoring XXActivity Level XXXXEasy Bolus Administration XXXXDatabase Of Food XXManages Carbs Well OursInsulet OmniPod Disetronic Spirit MiniMed Paradigm Animas IR-2020 Deltec Cozmo

20. March 22, 2008 CS 410 Green Team - Diabetes 20 Risk Overview M/LCheaper competitionPeople will not buyAcceptance M/MReconfigure for different insulinChange of insulin typeInsulin L/LMust be replaced. Partial data loss Loss of DeviceLoss L/LManual entry. Pump malfunctionsAny device defectMalfunction L/MManual entry. May lose dataPDA battery diesBattery Life VariesPump unable to send bolus updates Will upgrade work with new devices? Compatibility H/MAdd-on will make more expensiveWill insurance this feature?Insurance H/MHackersWill product be secureSecurity P/RImpactDescriptionRisk

21. March 22, 2008 CS 410 Green Team - Diabetes 21 Risk Matrix

22. March 22, 2008 CS 410 Green Team - Diabetes 22 Conclusion Regain control of life Historical data analysis Easier management of insulin distribution

23. March 22, 2008 CS 410 Green Team - Diabetes 23 Resources Diabetes Health. http://www.diabeteshealth.com/read/1999/02/01/1409.htmlhttp://www.diabeteshealth.com/read/1999/02/01/1409.html Medicinenet. http://www.medicinenet.com/diabetes_mellitushttp://www.medicinenet.com/diabetes_mellitus TechCrunch. http://www.techcrunch.com/2007/08/14/ipod-v-the-insulin- pump-adaptive-path-rises-to-the-challenge/http://www.techcrunch.com/2007/08/14/ipod-v-the-insulin- pump-adaptive-path-rises-to-the-challenge/ MedlinePlus Medical Encyclopedia. http://www.nlm.nih.gov/medlineplus/ency/imagepages/19212.htm http://www.nlm.nih.gov/medlineplus/ency/imagepages/19212.htm American Diabetes Association - Insulin Pumps. http://www.diabetes.org/type-1-diabetes/insulin-pumps.jsp http://www.diabetes.org/type-1-diabetes/insulin-pumps.jsp Compare Insulin Pumps. http://www.diabetesnet.com/diabetes_technology/insulin_pump_models.php http://www.diabetesnet.com/diabetes_technology/insulin_pump_models.php Minimed's Paradigm Insulin Pump. http://www.minimed.com/products/insulinpumps/ http://www.minimed.com/products/insulinpumps/ Deltec's Cozmore Insulin Pump. http://www.cozmore.com/default.cfm?CFID=6147989&CFTOKEN=2ffb9fef0 b64ead7-7FC5ADEE-3048-568B- BEF4AA6CF0A1CE63&jsessionid=c630e562d73b5537803a http://www.cozmore.com/default.cfm?CFID=6147989&CFTOKEN=2ffb9fef0 b64ead7-7FC5ADEE-3048-568B- BEF4AA6CF0A1CE63&jsessionid=c630e562d73b5537803a

24. March 22, 2008 CS 410 Green Team - Diabetes 24 More Resources Animas Insulin Pump http://www.animascorp.com/ http://www.animascorp.com/ Insulet's OmniPod Insulin Pump http://www.myomnipod.com/products/ http://www.myomnipod.com/products/ Disetronic's Spirit Insulin Pump http://www.roche.com/home.html http://www.roche.com/home.html

25. QUESTIONS??