1. Conference on Diabetes Types of diabetes mellitus type 1 -- insulin dependent type 2 – insulin independent Experiment with type 1 genetic or environmental w/immuno-supp Assay development radioimmunoassay – insulin concentrations histologic evaluation with Bata cell detection blood glucose measurement blood antibodies measurement

2. ISLETS Of LANGERHANS in pancreas

3. Acinar cells islet

5. ISLETS OF LANGERHANS stained with aldehyde-fuchsin, which selectively stains secretory granules of insulin-secreting Beta cells

6. kidney

10. Blood sugar concentrations Normal range 80 – 120 mg/dl Diabetic range >120 mg/dl

12. ROLES AND SPECIFIC ACTIONS OF ANTIOBODIES IN IMMUNITY COMPLEMENT - MEDIATED LYSIS OPSONIZATION - PROMOTE PHAGOCYTOSIS TOXIN NEUTRALIZATION PREVENTION OF MICROBIAL BINDING TO MUCOSAL SURFACE VIRUS NEUTRALIZATION - INTERFERES WITH CELL PENETRATION

13. EFFECTOR T CELLS DELAYED - TYPE HYPERSENSITIVITY T CELLS CYTOTOXIC CELLS DESTROYS TRANSPLANTED ORGANS

14. Measure antibodies in blood

15. radioimmunoassay for insulin blood concentrations